Calixarenes and their Relevance in Anticancer Drug Development

Soumyajeet      Paul; Ramaiah   Selladurai   Jeyaprakash; Aravinda      Pai; Hillemane      Venkatachalam; Bellur   Srinivas   Jayashree
doi:10.2174/1573406419666230703114605
Abstract

Calixarenes have always captured the attention of several researchers. They have the ability to entrap multiple molecules and form inclusion complexes with drugs due to their unique structure. Due to this property, they are being widely used in the development of several classes of drugs, most notably anticancer drugs. This review attempted to summarize the potential applications of calixarenes and its derivatives in the development of anticancer drugs, with a focus on the delivery of drug classes such as DNA intercalators, taxanes, DNA alkylators, and topoisomerase inhibitors. Calixarene-based macromolecular chemistry could therefore have a high potential for overcoming the toxicity of cancer chemotherapy and achieving targeted drug delivery.
Keywords: Calixarenes, chemotherapy, inclusion complex, targeted drug delivery, macromolecular chemistry, anticancer drugs.
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DOI https://dx.doi.org/10.2174/1573406419666230703114605	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638
Medicinal Chemistry

Calixarenes and their Relevance in Anticancer Drug Development

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