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Current Respiratory Medicine Reviews


ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Mini-Review Article

Hyper-coagulopathy State in COVID-19: A Pivotal Challenge

Author(s): Najmeh Nameh Goshay Fard, Atena Vaghf, Ekhlas Torfi, Saeid Shahrabi and Seyed Mohammad Sadegh Pezeshki*

Volume 19, Issue 3, 2023

Published on: 31 July, 2023

Page: [170 - 179] Pages: 10

DOI: 10.2174/1573398X19666230703094330

Price: $65


Background: The novel SARS-CoV-2 has caused a global pandemic. COVID-19 infection is described by the adverse impact on the population’s health and economy. Coagulopathy is associated with various thrombotic complications and disease severity. Therefore, this review aims to elucidate the pathophysiology of this coagulopathy.

Methods: Relevant English language literature was searched and retrieved from the Google Scholar search engine and PubMed database. We used “COVID-19”, “SARS-CoV-2”, “Coagulopathy”, “Thrombosis”, “Anticoagulation”, and “ARDS” as keywords.

Results: Several studies showed that the primary targets of SARS-CoV-2 are pneumocytes, immune cells, and vascular endothelial cells. Coagulopathy appears to induce more thrombotic complications than hemorrhagic events. The critically ill patients stimulate the coagulopathy state and thrombosis complication through cytokine storm, systemic inflammation, complement cascade, and platelets. Accordingly, thromboembolic complications cause mortality among COVID-19-infected patients and can negatively affect disease management outcomes and treatment.

Conclusion: A pivotal clinical feature of acute COVID-19 infection is coagulopathy and prothrombotic events, which are associated with excessive arterial and venous thrombosis, microvascular thrombosis, and adverse clinical outcomes. Therefore, adopting an approach for preventing, treating, and reducing thrombotic and bleeding events in these patients is necessary.

Keywords: COVID-19, SARS-CoV-2, coagulopathy, thrombosis, Anticoagulation, ARDS.

Graphical Abstract
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