Title:Recent Developments and Future Prospects of Natural Antimicrobial
Bioactive Metabolites Obtained from Endophytic Bacterial Isolate
Volume: 20
Issue: 3
Author(s): Moti Lal and Neelam*
Affiliation:
- Department of General Medicine,
IMS BHU, Varanasi, India
Keywords:
Endophyte bacteria, secondary bioactive metabolites, antimicrobial properties, structural elucidation, scanning electron microscope, Adathoda beddomei.
Abstract:
Background: Adathoda beddomei (Adosa), a kind of softwood, evergreen, perennial
shrub, has been used as a source of endophyte bacteria. Adhatoda beddomei has a wide variety of
chemicals, including anthocyanins, aminophylline, alkaloids, cardiac glycosides, isoprenaline,
triterpenoids, resins, flavonoids, tannins, sterol, saponins, etc. The root, stem, and leaf parts of Adathoda
beddomei are most often used in indigenous medicine. Moreover, the root bark is also used to
cure several conditions, including leprosy, fever, and bleeding.
Objective: Some important bioactive metabolites were obtained from endophytes bacteria and analyzed
through various techniques (NMR, MASS, FTIR, HPLC, and UV- spectrophotometer) for
their bioactive secondary metabolites.
Methods: In silico calculation was performed to reveal bioactive metabolites with the potential to
be antibacterial, and their primary mode of action may include dissolving bacterial and fungal cell
walls.
Results: The antimicrobial activity of Adathoda beddomei was demonstrated against different pathogenic
and non-pathogenic bacteria. Identification of endophytes was done based on external morphological
characteristics with the help of a scanning electron microscope (SEM).
Conclusion: Natural compounds derived from endophyte bacteria with a very low molecular
mass can be used to discover new and important structures for different pharmaceuticals and
agrochemicals.