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Mini-Review Article

Intracellular Compartmentalization: A Key Determinant of MicroRNA Functions

Author(s): Rohit Nalavade* and Mohini Singh*

Volume 12, Issue 2, 2023

Published on: 19 April, 2023

Page: [114 - 130] Pages: 17

DOI: 10.2174/2211536612666230330184006

Price: $65

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Abstract

Being an integral part of the eukaryotic transcriptome, miRNAs are regarded as vital regulators of diverse developmental and physiological processes. Clearly, miRNA activity is kept in check by various regulatory mechanisms that control their biogenesis and decay pathways. With the increasing technical depth of RNA profiling technologies, novel insights have unravelled the spatial diversity exhibited by miRNAs inside a cell. Compartmentalization of miRNAs adds complexity to the regulatory circuits of miRNA expression, thereby providing superior control over the miRNA function. This review provides a bird’s eye view of miRNAs expressed in different subcellular locations, thus affecting the gene regulatory pathways therein. Occurrence of miRNAs in diverse intracellular locales also reveals various unconventional roles played by miRNAs in different cellular organelles and expands the scope of miRNA functions beyond their traditionally known repressive activities.

Keywords: Eukaryotic transcriptome, biogenesis, prominent roles, endogenously or exogenously, miRNAs, gene regulatory pathways.

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Graphical Abstract

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