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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

Isocyanide-based Multicomponent Reactions (IMCRs) in Water or Aqueous Biphasic Systems

Author(s): Chitteti Divyavani, Pannala Padmaja and Pedavenkatagari Narayana Reddy*

Volume 21, Issue 2, 2024

Published on: 09 June, 2023

Page: [140 - 165] Pages: 26

DOI: 10.2174/1570179420666230330170845

Price: $65

Abstract

Background: Isocyanide is an intriguing one-carbon synthon that is frequently employed in a variety of carbon-carbon and carbon-heteroatom bond-forming reactions. Isocyanide-based multicomponent reactions (IMCRs) are effective synthetic tools in organic synthesis for the preparation of complex heterocyclic molecules. The IMCRs in water have become an attractive research direction, enabling simultaneous growth of both IMCRs and green solvents towards ideal organic synthesis.

Objective: The goal of this review is to provide a general overview of IMCRs in water or biphasic aqueous systems for accessing various organic molecules, as well as an examination of their benefits and mechanistic insights.

Conclusion: High atom economies, mild reaction conditions, high yields, and catalyst-free processes are crucial features of these IMCRs in water or biphasic aqueous systems.

Keywords: Isocyanide-based multicomponent reactions (IMCRs), water, aqueous biphasic systems, heterocyclic compounds, reaction mechanism, bond-forming reactions, organic molecules.

Graphical Abstract
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