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Current Drug Delivery


ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Clinical Trial

Comparing Recovery from Desflurane and Sevoflurane in Patients with Different Body Fat Percentages: A Randomized Controlled Trial

Author(s): Silu Cao, Huijuan Wang, Lijun Tang and Guanghui An*

Volume 21, Issue 4, 2024

Published on: 07 April, 2023

Page: [623 - 630] Pages: 8

DOI: 10.2174/1567201820666230328115354

Price: $65


Introduction: Increased body fat may influence the partition coefficients of inhaled anesthetics. We compared patient responses to desflurane and sevoflurane anesthesia, as measured by a quicker recovery and fewer complications, in patients with higher body fat percentages, not only obese people.

Methods: This study included 120 patients. Participants were stratified into low or high body fat percentages groups using bioelectrical impedance analysis and were randomized 1:1 to receive desflurane or sevoflurane as an inhaled anesthetic, recorded as Low-Desflurane, Low-Sevoflurane, High- Desflurane, and High-Sevoflurane. Recovery time, Riker sedation–agitation scale scores, and complications were recorded over 1 hour in the post-anesthesia care unit.

Results: A total of 106 patients were analyzed. There were no significant differences in the overall recovery time between the patient subgroups with higher and lower body fat percentages; in addition, there were no significant differences in the incidence of nausea, vomiting,dizziness, or headache (all p>0.05). However, the incidence of agitation emergence in the HighSevoflurane subgroup was significantly higher compared to the High-Desflurane subgroup (33.3% vs.7.41%; p = 0.043).

Conclusion: In conclusion, for patients with a lower body fat percentage, both desflurane and sevoflurane can provide good and fast recovery; for patients with a higher body fat percentage,desflurane may provide better recovery with a lower incidence of agitation emergence compared to sevoflurane.

Keywords: Desflurane, sevoflurane, body fat percentage, anesthesia, VRG, BMI.

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