Introduction: Increased body fat may influence the partition coefficients of inhaled anesthetics. We compared patient responses to desflurane and sevoflurane anesthesia, as measured by a quicker recovery and fewer complications, in patients with higher body fat percentages, not only obese people.
Methods: This study included 120 patients. Participants were stratified into low or high body fat percentages groups using bioelectrical impedance analysis and were randomized 1:1 to receive desflurane or sevoflurane as an inhaled anesthetic, recorded as Low-Desflurane, Low-Sevoflurane, High- Desflurane, and High-Sevoflurane. Recovery time, Riker sedation–agitation scale scores, and complications were recorded over 1 hour in the post-anesthesia care unit.
Results: A total of 106 patients were analyzed. There were no significant differences in the overall recovery time between the patient subgroups with higher and lower body fat percentages; in addition, there were no significant differences in the incidence of nausea, vomiting,dizziness, or headache (all p>0.05). However, the incidence of agitation emergence in the HighSevoflurane subgroup was significantly higher compared to the High-Desflurane subgroup (33.3% vs.7.41%; p = 0.043).
Conclusion: In conclusion, for patients with a lower body fat percentage, both desflurane and sevoflurane can provide good and fast recovery; for patients with a higher body fat percentage,desflurane may provide better recovery with a lower incidence of agitation emergence compared to sevoflurane.
[http://dx.doi.org/10.1213/00000539-199103000-00007] [PMID: 1994760]
[http://dx.doi.org/10.1097/00000542-199103000-00017] [PMID: 2001028]
[http://dx.doi.org/10.1213/01.ANE.0000136472.01079.95] [PMID: 15562085]
[http://dx.doi.org/10.3390/jcm11010162] [PMID: 35011903]
[http://dx.doi.org/10.1093/bja/aep374] [PMID: 20037150]
[http://dx.doi.org/10.1111/ijpo.242] [PMID: 24961794]
[http://dx.doi.org/10.1038/ijo.2010.5] [PMID: 20125098]
[http://dx.doi.org/10.1381/096089206777346691] [PMID: 16756732]
[http://dx.doi.org/10.1007/s12630-015-0405-0] [PMID: 26001751]
[http://dx.doi.org/10.1111/aas.12435] [PMID: 25395384]
[http://dx.doi.org/10.15537/smj.2019.12.24693] [PMID: 31828275]