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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

APOE4等位基因和性别对阿尔茨海默病海马体、内嗅皮层和梭形回腿萎缩率的影响

卷 19, 期 14, 2022

发表于: 15 March, 2023

页: [943 - 953] 页: 11

弟呕挨: 10.2174/1567205020666230309113749

价格: $65

摘要

背景：海马体、内嗅皮质和梭状回是在早期阿尔茨海默病 (AD) 期间恶化的大脑区域。 ApoE4 等位基因已被确定为 AD 发展的危险因素，与大脑中淀粉样蛋白 β (Aβ) 斑块聚集的增加有关，并导致海马区萎缩。然而，据我们所知，尚未研究 AD 患者随时间恶化的速度，无论是否有 ApoE4 等位基因。 方法：在这项研究中，我们首次使用阿尔茨海默氏病神经影像学倡议 (ADNI) 数据集分析有和没有 ApoE4 的 AD 患者的这些脑结构萎缩。 结果：发现这些脑区体积在 12 个月内的减少率与 ApoE4 的存在有关。此外，与之前的研究不同，我们发现女性和男性患者的神经萎缩没有差异，这表明 ApoE4 的存在与 AD 中的性别差异无关。 结论：我们的结果证实并扩展了之前的发现，表明 ApoE4 等位基因逐渐影响受 AD 影响的大脑区域。

关键词: 阿尔茨海默病，海马体，APOE基因，内嗅皮层，梭状回，疾病进展，性别差异。

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