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Current Cancer Therapy Reviews

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ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

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Mini-Review Article

Endometrial Cancer Stem Cells Related Signaling Pathways

Author(s): Fatemeh Khojasteh Pour, Mona Keivan, Farhoodeh Ghaedrahmati, Najmieh Saadati, Farideh Moramezi, Roshan Nikbakht and Maryam Farzaneh*

Volume 19, Issue 4, 2023

Published on: 05 May, 2023

Page: [284 - 291] Pages: 8

DOI: 10.2174/1573394719666230306145642

Price: $65

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Abstract

Endometrial cancer is gynecologic cancer that occurs in the uterus. Endometrial cancer stem cells (ECSC) are a small population of cancer cells that represent a crucial role in the metastasis of endometrial cancer cells to other organs in the body. ECSC can proliferate and give rise to mature cancer cells, which are found to participate in the aggressiveness of metastatic lesions. Therefore, targeting ECSC can be a valuable strategy for drug development against the metastasis of endometrial cancer. Previous studies have demonstrated that several signaling pathways, including Wnt, mTOR, EGFR, NOTCH, STAT3, VEGF, and SHH show modest effects and regulate the growth, epithelial-to-mesenchymal transition (EMT), and tumorigenesis of ECSC. Non-coding RNAs (ncRNAs) also play an important role in ECSC self-renewal, progression, and drug resistance. Hence, targeting these pathways might be a novel therapeutic approach for endometrial cancer diagnosis and therapy. This mini-review aims to characterize the main signaling pathways involved in the stimulation of ECSCs proliferation and tumorigenesis.

Keywords: Endometrial cancer, endometrial cancer stem cells, signaling pathways, miRNAs, metastasis, tumorigenesis.

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