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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Ultrasound-promoted Regioselective Synthesis of 2-aryl-quinazolinones Using Citric Acid as a Natural and Efficient Media and Catalyst

Author(s): Mohammad Nikpassand* and Leila Zare Fekri

Volume 20, Issue 8, 2023

Published on: 31 March, 2023

Page: [763 - 769] Pages: 7

DOI: 10.2174/1570178620666230222101139

Price: $65

Abstract

A three-component reaction under ultrasound irradiation and with a catalytic amount of citric acid was presented for the synthesis of a series of 2-aryl-quinazolin-4(1H)-ones with excellent efficiency and short reaction time. This one-pot reaction with 2-aminobenzonitrile, ammonium hydroxide or glycine and benzaldehydes is a clean and safe route for the environment at room temperature. Mild reaction conditions, green environment, excellent performance, simple method and reduction of environmental consequences are the advantages of the present method. The structures of many synthesized 2-aryl-quinazolin-4(1H)-one compounds were confirmed by 1H, 13C NMR and FTIR spectral data and elemental analysis.

Keywords: Ultrasound irradiation, benzaldehydes, FTIR spectral, citric acid, Dihydroquinazolinones, acylamine benzamides.

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