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Recent Patents on Anti-Cancer Drug Discovery


ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

Review Article

Puerarin: An Anticancer and Anti-Inflammatory Agent

Author(s): Harinder Singh, Priyanka Kriplani*, Sweta Kamboj and Kumar Guarve

Volume 19, Issue 1, 2024

Published on: 20 January, 2023

Page: [18 - 36] Pages: 19

DOI: 10.2174/1574892818666230111152024

Price: $65


Objectives: Puerarin is a well-known anti-inflammatory agent which has demonstrated its potential to cure numerous ailments. Though many plants are reported in the literature, still their mechanisms are unversed. In this review, numerous mechanisms of puerarin to cure cancer and other inflammatory disorders, pharmacokinetics and adverse events, and boulevards of further research are discussed.

Methods: Organized research was done using ScienceDirect, PubMed, ResearchGate, Google Scholar, Google Patents and ScienceDirect Medline to quest all the available data to date on puerarin. Different keywords used were “puerarin”, “Pueraria tuberosa”, “cancer”, “antiinflammatory”, “cardiovascular”, “IBD”, “pharmacokinetics” etc.

Results: One hundred thirty-six articles and thirteen patents were studied. Puerarin is reported to treat chronic problems like inflammation, sexual dysfunction, cardiovascular diseases and menaces such as colon, stomach, lung and breast cancer by numerous mechanisms, as these ailments do not progress via a single independent pathway.

Conclusion: This article will definitely help budding researchers scrutinize the wealth of information on the therapeutic chattels of puerarin and identify the gaps that have forbidden its application as a potential molecule to cure various ailments.

Keywords: Cancer, extraction, inflammation, Pueraria tuberosa, puerarin, pharmacokinetics.

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