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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Review Article

Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery

Author(s): Benu Chaudhary, Parveen Kumar, Preeti Arya, Deepak Singla, Virender Kumar, Davinder Kumar, Roshan S, Sheetu Wadhwa, Monica Gulati, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta and Madan Mohan Gupta*

Volume 23, Issue 13, 2022

Published on: 19 January, 2023

Page: [1027 - 1053] Pages: 27

DOI: 10.2174/1389200224666230110145513

Price: $65

Abstract

Cancer is characterized by disrupted molecular variables caused by cells that deviate from regular signal transduction. The uncontrolled segment of such cancerous cells annihilates most of the tissues that contact them. Gene therapy, immunotherapy, and nanotechnology advancements have resulted in novel strategies for anticancer drug delivery. Furthermore, diverse dispersion of nanoparticles in normal stroma cells adversely affects the healthy cells and disrupts the crosstalk of tumour stroma. It can contribute to cancer cell progression inhibition and, conversely, to acquired resistance, enabling cancer cell metastasis and proliferation. The tumour's microenvironment is critical in controlling the dispersion and physiological activities of nano-chemotherapeutics which is one of the targeted drug therapy. As it is one of the methods of treating cancer that involves the use of medications or other substances to specifically target and kill off certain subsets of malignant cells. A targeted therapy may be administered alone or in addition to more conventional methods of care like surgery, chemotherapy, or radiation treatment. The tumour microenvironment, stromatogenesis, barriers and advancement in the drug delivery system across tumour tissue are summarised in this review.

Keywords: Tumor microenvironment, nanoparticles, immunotherapy, drug delivery, gene therapy, proliferation.

Graphical Abstract
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