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Current Women`s Health Reviews

Editor-in-Chief

ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Research Article

Comparison of Maternal and Neonatal Outcomes Among COVID-19 and Healthy Pregnant Women in the West of Iran: A Retrospective Cohort Study

Author(s): Nahid Radnia, Neda Alimohammadi, Maryam Garousian, Elaheh Talebi-Ghane, Behnaz Basiri, Saeed Bashirian, Tahereh Eskandarlo and Fariba Daneshvar*

Volume 19, Issue 4, 2023

Published on: 29 December, 2022

Article ID: e011122210538 Pages: 7

DOI: 10.2174/1573404819666221101124433

Price: $65

Abstract

Background: In the COVID-19 epidemic, pregnant women, fetuses, and newborns are a high-risk population that is more susceptible than the general population. These groups are more susceptible to serious respiratory illnesses and pneumonia because of their weakened immune systems. This study compared maternal and neonatal outcomes in postpartum women with COVID-19 with similar healthy women at the hospital.

Methods: In this retrospective cohort study, the characteristics of 100 pregnant women with COVID- 19 (confirmed by a positive PCR test during pregnancy) were compared to 150 healthy pregnant women who were referred to Fatemieh Hospital in Hamadan from March, 2020 to February, 2021. The maternal and neonatal outcomes were collected from the medical record of patients and analyzed using SPSS software (Ver. 26).

Results: No significant differences were observed in the average ages (± standard deviation) of the two groups of COVID-19 (30.25 ± 6.24 years) and healthy (29.48 ± 6.73 years) women. In this study, pregnant women were infected with COVID-19 from weeks 7 to 41 of gestation, with a median infection time of 35 weeks. The odds ratio (95% confidence interval) of pre-eclampsia and preterm birth was significantly higher in women with COVID-19 than in healthy women with the following values 2.79 (1.61, 7.34) and 22.26 (2.86, 173.33), respectively.

Conclusion: Pregnant women suffering from COVID-19 had considerably greater rates of gestational issues, neonatal difficulties, pre-eclampsia, and premature delivery, according to the findings of this study. During epidemics, it is advised that pregnant women and their newborns receive more basic care.

Keywords: COVID-19, pregnant women, pregnancy outcome, neonatal, maternal-child health centers, PCR.

Graphical Abstract
[2]
Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol 2020; 92(4): 401-2.
[http://dx.doi.org/10.1002/jmv.25678] [PMID: 31950516]
[3]
Jafari M, Pormohammad A, Sheikh Neshin SA, et al. Clinical characteristics and outcomes of pregnant women with COVID‐19 and comparison with control patients: A systematic review and meta‐analysis. Rev Med Virol 2021; 31(5): 1-16.
[http://dx.doi.org/10.1002/rmv.2208] [PMID: 33387448]
[4]
Jenabi E, Bashirian S, Khazaei S, Masoumi SZ, Ghelichkhani S, Goodarzi F. Pregnancy outcomes among symptomatic and asymptomatic women infected with COVID-19 in the west of Iran: A case-control study. J Matern Fetal Neonatal Med 2020; 2020: 1-3.
[PMID: 33322959]
[5]
Farnoosh G, Alishiri G, Zijoud SH, Dorostkar R, Farahani AJ. Understanding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19) based on available evidence-a narrative review. Mil Med 2020; 22(1): 1-11.
[6]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]
[7]
Burke RM, Killerby ME, Newton S, et al. Symptom profiles of a convenience sample of patients with COVID-19-United States, January-April 2020. MMWR Morb Mortal Wkly Rep 2020; 69(28): 904-8.
[http://dx.doi.org/10.15585/mmwr.mm6928a2] [PMID: 32673296]
[8]
Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N Engl J Med 2020; 382(13): 1199-207.
[http://dx.doi.org/10.1056/NEJMoa2001316] [PMID: 31995857]
[9]
Nikpour M, Behmanesh F, Darzipoor M, Sadeghi Haddad Zavareh M. Pregnancy outcomes and clinical manifestations of Covid-19 in pregnant women: A narrative review. J Mil Med 2020; 22(2): 177-83.
[10]
Doktorchik C, Premji S, Slater D, Williamson T, Tough S, Patten S. Patterns of change in anxiety and depression during pregnancy predict preterm birth. J Affect Disord 2018; 227: 71-8.
[http://dx.doi.org/10.1016/j.jad.2017.10.001] [PMID: 29053978]
[11]
Yu N, Li W, Kang Q, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre, descriptive study. Lancet Infect Dis 2020; 20(5): 559-64.
[http://dx.doi.org/10.1016/S1473-3099(20)30176-6] [PMID: 32220284]
[12]
Mohr-Sasson A, Chayo J, Bart Y, et al. Laboratory characteristics of pregnant compared to non-pregnant women infected with SARS-CoV-2. Arch Gynecol Obstet 2020; 302(3): 629-34.
[http://dx.doi.org/10.1007/s00404-020-05655-7] [PMID: 32572616]
[13]
Zambrano LD, Ellington S, Strid P, et al. Update: Characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States, January 22–October 3, 2020. MMWR Morb Mortal Wkly Rep 2020; 69(44): 1641-7.
[http://dx.doi.org/10.15585/mmwr.mm6944e3] [PMID: 33151921]
[14]
Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet 2020; 395(10226): 809-15.
[http://dx.doi.org/10.1016/S0140-6736(20)30360-3] [PMID: 32151335]
[15]
Sattari M, Bashirian S, Masoumi SZ, et al. Evaluating clinical course and risk factors of infection and demographic characteristics of pregnant women with COVID-19 in Hamadan Province, West of Iran. J Res Health Sci 2020; 20(3)e00488
[http://dx.doi.org/10.34172/jrhs.2020.22] [PMID: 33169720]
[16]
Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382(8): 727-33.
[http://dx.doi.org/10.1056/NEJMoa2001017] [PMID: 31978945]
[17]
Papageorghiou AT, Deruelle P, Gunier RB, Rauch S, García-May PK, Mhatre M. Preeclampsia and COVID-19: Results from the INTERCOVID prospective longitudinal study. Am J Obstet Gynecol 2021; 225(3): 1-17.
[18]
Jayaram A, Buhimschi IA, Aldasoqi H, et al. Who said differentiating preeclampsia from COVID-19 infection was easy? Pregnancy Hypertens 2021; 26: 8-10.
[http://dx.doi.org/10.1016/j.preghy.2021.07.248] [PMID: 34392167]
[19]
Sayad B, Mohseni AZ, Mansouri F, et al. Pregnancy, preeclampsia, and COVID-19: susceptibility and mechanisms: A review study. Int J Fertil Steril 2022; 16(2): 64-9.
[PMID: 35639648]
[20]
London V, McLaren R Jr, Atallah F, et al. The relationship between status at presentation and outcomes among pregnant women with COVID-19. Am J Perinatol 2020; 37(10): 991-4.
[http://dx.doi.org/10.1055/s-0040-1712164] [PMID: 32428964]
[21]
Azh N, Pakniat H, Rajabi M, Ranjkesh F. Evaluation of pregnancy outcomes in pregnant women with COVID-19 in Qazvin 1399. Majallah-i Ipidimiyuluzhi-i Iran 2021; 16: 10-9.
[22]
Moaya M, Shahali S, Farhoudi B. Maternal and neonatal outcomes of pregnant women with COVID-19 in Amir-al-momenin hospital during March to May 2020. Iranian J Obstetrics. Gynecol Infert 2020; 23(9): 35-42.
[23]
Chen S, Huang B, Luo D, Li X, Yang F, Zhao Y. Pregnancy with new coronavirus infection: Clinical characteristics and placental pathological analysis of three cases. Chin J Pathol 2020; 49(5): 418-23.
[24]
Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: A reference table for clinicians. Obstet Gynecol 2009; 114(6): 1326-31.
[http://dx.doi.org/10.1097/AOG.0b013e3181c2bde8] [PMID: 19935037]

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