Title:Are Monocyte, %M and WBC Biomarkers in the First Trimester Screening
Test?
Volume: 3
Author(s): Ozlem Oz*Ataman Gonel
Affiliation:
- Department of Medical Genetics, Harran University, Şanlıurfa, Turkey
Keywords:
Pregnancy, Double screening test, Beta HCG, PAPP-A, Hemogram, Monocyte, WBC, MPV.
Abstract:
Background: Differences in free beta HCG and PAPP-A values, which are among the biochemical parameters in the double screening test, are frequently used
for pregnancy follow-up, allowing aneuploidy and triploidy risk to be determined. In recent studies, it is suggested that the modified hemogram
indices have gained importance as a marker in the prognosis of diseases.
Objective: In this study, we aimed to determine the hematological parameters, which are routinely applied in the first trimester of pregnancy, have any value
in predicting the risk increase in the double screening test and in early diagnosis.
Methods: Pregnant women who conceived spontaneously and had double screening tests were included in the study. CBC results that were studied together
with the first trimester screening test were reported. The patients were divided into two groups according to the results of the screening test as the
combined risk ratio.
Results: The mean age was found to be significantly higher in the high-risk group than in the low-risk group. Monocyte, % M and WBC values were
significantly lower in the high-risk group (0,483±0,140, 5,58±1,44 and 8,75±2,12, respectively). There was no significant difference in NLR and
PLR values compared between the groups. MPV values were lower and PAPP-A, PAPP-A MoM values were significantly lower in high-risk
group compared to the low-risk group.
Conclusion: The findings support low Monocyte, % M and WBC values as a potential marker for the identification of high risk pregnancy in otherwise healthy
pregnant women. The results indicate that CBC parameters commonly used in pregnancy can be used to predict the prognosis.
