Title:Advances in the Therapeutic Use of Non-Ergot Dopamine Agonists in the
Treatment of Motor and Non-Motor Symptoms of Parkinson’s Disease
Volume: 21
Issue: 5
Author(s): Xiao-Zhong Jing, Hui-Jia Yang, Reyisha Taximaimaiti and Xiao-Ping Wang*
Affiliation:
- Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University, School of
Medicine, Shanghai, China
- Department of Neurology, TongRen Hospital, Shanghai Jiao Tong University, School of
Medicine, Shanghai, China
Keywords:
Advances, dopamine (DA) agonists, motor symptoms, non-motor symptoms, Parkinson's disease, treatment.
Abstract: Dopamine (DA) agonists, as an excellent dopamine replacement therapy for patients with
early and advanced Parkinson's disease (PD), play a vital role in controlling motor and several nonmotor
symptoms. Besides, the application of DA agonists may delay levodopa therapy and the associated
risk of motor complications. Indeed, each DA agonist has unique pharmacokinetic and pharmacodynamic
characteristics and therefore has different therapeutic efficacy and safety profile. The comorbidities,
significant non-motor manifestations, concomitant medications, and clinical features of PD
individuals should guide the selection of a specific DA agonist to provide a more patient-tailored
treatment option. Thorough knowledge of DA agonists helps clinicians better balance clinical efficacy
and side effects. Therefore, this review refers to recent English-written articles on DA agonist therapy
for PD patients and summarizes the latest findings on non-ergot DA agonists as well as the advantages
and disadvantages of each compound to help clinicians in the selection of a specific DA agonist. In
addition, novel D1/D5 partial agonists and new formulations of DA agonists are also discussed