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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Research Article

Green Synthesis of Mono, Bis and Tris Aminobenzochromenes and Benzopyranochromenes using Fe3O4@Sio2@ Vanillin/Vitamin B1 Nanoparticles: A New, Mild, Simple and Effective Bronsted Acid Catalyst for the Synthesis of Chromenes

Author(s): Leila Zare Fekri*, Mohaddeseh Kadivar-Kalmarzi and Zahra Hojjati-Zolpirani

Volume 20, Issue 4, 2023

Published on: 28 October, 2022

Page: [470 - 483] Pages: 14

DOI: 10.2174/1570179419666220822141726

Price: $65


Objective: Vanillin/Vitamin B1 (Thiamine) supported Fe3O4@Sio2 nanoparticles (Fe3O4 @SP@VT) were synthesized and thoroughly analyzed, and were used for the green and efficient synthesis of chromenes using the multicomponent reaction of aldehyde, malononitrile and 4-hydroxy coumarin, as well as the multicomponent reaction of aldehyde, α-naphthol or β–naphthol and 4-hydroxy coumarin.

Methods: The reaction was performed under grinding conditions, and at the end of the reaction, the catalyst was separated in the presence of a strong magnet and can be recovered 10 times.

Results: The advantages of this method are high purity of products, short times, higher yield, easy separation and cheap raw materials.

Conclusion: We have developed Fe3O4@SP@VT catalyzed multicomponent synthesis of aminobenzochromenes using the reaction of benzaldehyde, malononitrile and naphthol and multicomponent synthesis of benzopyranochromenes using benzaldehyde, 4-hydroxycoumarin and β-naphthol under grind technique.

Keywords: Vanillin/vitamin B1 (Thiamine), aminobenzochromenes, benzopyranochromenes, green chemistry, rheumatism, arthritis.

Graphical Abstract
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