Title:Peptide-based Nanomaterials: Self-assembly and Applications
Volume: 23
Issue: 4
Author(s): Lina Tan, Ren Huan, Li Fang Wu, Yanni Bao, Yu Chen Ma, Qian Li Zou*Jin Yong*
Affiliation:
- School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
- School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
Keywords:
Peptide self-assembly, nano-micelle, nano-fiber, hydrogel, nano-particle, therapeutic application.
Abstract: The self-assembly behavior of polypeptides is common in nature. Compared with monopeptides,
polypeptide-based self-assembled nanomaterials with ordered structures have good thermal
stability, mechanical stability, semi-conductivity, piezoelectric and optical properties. In recent years,
the self-assembly of polypeptides has become a hot topic in the material science and biomedical field.
By reasonably adjusting the molecular structure of the polypeptide and changing the external environment
of the polypeptide, the polypeptide can be self-assembled or triggered by non-covalent bonding
forces such as hydrogen bond, hydrophobicity, and π - π accumulation to form specific polypeptide
assemblies such as nanoparticles, hydrogels, nanofibers, and micelles. Due to good biocompatibility
and controllable degradability, polypeptide-based self-assembled nanomaterials have been widely
used in the fields of nanotechnology, imaging technology, biosensor, and biomedical science. As a
new drug delivery system, the polypeptide-drug conjugate has the advantages of low toxicity, high
efficiency, enhanced drug stability, and avoiding side effects. This paper reviews the research progress
of polypeptide-drug self-assembly nanostructure in recent years. Several structural models of
polypeptide self-assembly technology and the mechanism of polypeptide self-assembly are introduced.
Then the assembly form of polypeptide-drug self-assembly and the application of selfassembly
compound therapy is described.