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Case Report

Takotsubo Cardiomyopathy and COVID-19: A Case Report and Literature Review

Author(s): Solís Gabriel José, Edgar Francisco Carrizales-Sepúlveda*, Raymundo Vera-Pineda, Eliu Jefte Morales-Rendón, José de Jesús Ortiz-Corona and Ramiro Flores-Ramírez*

Volume 19, Issue 2, 2023

Published on: 16 September, 2022

Article ID: e180822207660 Pages: 9

DOI: 10.2174/1573403X18666220818155039

Price: $65

Abstract

Background: Takotsubo cardiomyopathy is characterized by transient regional ventricular abnormalities in the absence of coronary artery disease and is reported as a complication of COVID-19.

Case Presentation: It can have a diverse clinical presentation, occasionally resembling an acute coronary syndrome, and progress to acute heart failure and cardiogenic shock, adversely affecting patients' prognosis. A high index of suspicion and a thorough diagnostic approach supported by ancillary studies like echocardiography and coronary angiography is key for an accurate diagnosis and correct medical treatment. Herein, we report a patient with severe COVID-19 who developed Takotsubo cardiomyopathy.

Conclusion: We also present a detailed literature review regarding the relationship between COVID-19 and Takotsubo cardiomyopathy.

Keywords: Takotsubo cardiomyopathy, stress cardiomyopathy, apical ballooning syndrome, COVID-19, SARS-CoV-2 infection, cardiogenic shock, heart failure.

Graphical Abstract

[1]
Berlin DA, Gulick RM, Martinez FJ. Severe Covid-19. N Engl J Med 2020; 383(25): 2451-60.
[http://dx.doi.org/10.1056/NEJMcp2009575] [PMID: 32412710]
[2]
Akhmerov A, Marbán E. COVID-19 and the heart. Circ Res 2020; 126(10): 1443-55.
[http://dx.doi.org/10.1161/CIRCRESAHA.120.317055] [PMID: 32252591]
[3]
Carrizales-Sepúlveda EF, Vera-Pineda R, Flores-Ramírez R, et al. Echocardiographic manifestations in COVID-19: A review. Heart Lung Circ 2021; 30(8): 1117-29.
[http://dx.doi.org/10.1016/j.hlc.2021.02.004] [PMID: 33715970]
[4]
Salah HM, Mehta JL. Takotsubo cardiomyopathy and COVID-19 infection. Eur Heart J Cardiovasc Imaging 2020; 21(11): 1299-300.
[http://dx.doi.org/10.1093/ehjci/jeaa236] [PMID: 32949135]
[5]
Nishiga M, Wang DW, Han Y, Lewis DB, Wu JC. COVID-19 and cardiovascular disease: From basic mechanisms to clinical perspectives. Nat Rev Cardiol 2020; 17(9): 543-58.
[http://dx.doi.org/10.1038/s41569-020-0413-9] [PMID: 32690910]
[6]
Greenberg A, Pemmasani G, Yandrapalli S, Frishman WH. Cardiovascular and cerebrovascular complications with COVID-19. Cardiology 2021; 29(3): 143-9.
[PMID: 33758123]
[7]
Chung MK, Zidar DA, Bristow MR, et al. COVID-19 and cardiovascular disease: From bench to bedside. Circ Res 2021; 128(8): 1214-36.
[http://dx.doi.org/10.1161/CIRCRESAHA.121.317997] [PMID: 33856918]
[8]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]
[9]
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; 323(11): 1061-9.
[http://dx.doi.org/10.1001/jama.2020.1585] [PMID: 32031570]
[10]
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 2020; 395(10229): 1054-62.
[http://dx.doi.org/10.1016/S0140-6736(20)30566-3] [PMID: 32171076]
[11]
Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382(18): 1708-20.
[http://dx.doi.org/10.1056/NEJMoa2002032] [PMID: 32109013]
[12]
Wu Z, McGoogan JM. Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA 2020; 323(13): 1239-42.
[http://dx.doi.org/10.1001/jama.2020.2648] [PMID: 32091533]
[13]
Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med 2020; 46(5): 846-8.
[http://dx.doi.org/10.1007/s00134-020-05991-x] [PMID: 32125452]
[14]
Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA 2020; 323(16): 1574-81.
[http://dx.doi.org/10.1001/jama.2020.5394] [PMID: 32250385]
[15]
Goyal P, Choi JJ, Pinheiro LC, et al. Clinical characteristics of covid-19 in New York city. N Engl J Med 2020; 382(24): 2372-4.
[http://dx.doi.org/10.1056/NEJMc2010419] [PMID: 32302078]
[16]
Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 2020; 323(20): 2052-9.
[http://dx.doi.org/10.1001/jama.2020.6775] [PMID: 32320003]
[17]
Ghadri JR, Wittstein IS, Prasad A, et al. International expert consensus document on takotsubo syndrome (Part I): Clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J 2018; 39(22): 2032-46.
[http://dx.doi.org/10.1093/eurheartj/ehy076] [PMID: 29850871]
[18]
Templin C, Ghadri JR, Diekmann J, et al. Clinical features and outcomes of takotsubo (stress) cardiomyopathy. N Engl J Med 2015; 373(10): 929-38.
[http://dx.doi.org/10.1056/NEJMoa1406761] [PMID: 26332547]
[19]
Jabri A, Kalra A, Kumar A, et al. Incidence of stress cardiomyopathy during the coronavirus disease 2019 pandemic. JAMA Netw Open 2020; 3(7): e2014780.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.14780] [PMID: 32644140]
[20]
Meyer P, Degrauwe S, Van Delden C, Ghadri JR, Templin C. Typical takotsubo syndrome triggered by SARS-CoV-2 infection. Eur Heart J 2020; 41(19): 1860.
[http://dx.doi.org/10.1093/eurheartj/ehaa306] [PMID: 32285915]
[21]
Dabbagh MF, Aurora L, D’Souza P, Weinmann AJ, Bhargava P, Basir MB. Cardiac tamponade secondary to covid-19. JACC Case Rep 2020; 2(9): 1326-30.
[http://dx.doi.org/10.1016/j.jaccas.2020.04.009] [PMID: 32328588]
[22]
Minhas AS, Scheel P, Garibaldi B, et al. Takotsubo syndrome in the setting of COVID-19. JACC Case Rep 2020; 2(9): 1321-5.
[http://dx.doi.org/10.1016/j.jaccas.2020.04.023] [PMID: 32363351]
[23]
Nguyen D, Nguyen T, De Bels D, Castro Rodriguez J. A case of Takotsubo cardiomyopathy with COVID 19. Eur Heart J Cardiovasc Imaging 2020; 21(9): 1052.
[http://dx.doi.org/10.1093/ehjci/jeaa152] [PMID: 32395765]
[24]
Moderato L, Monello A, Lazzeroni D, et al. Takotsubo syndrome during SARS-CoV-2 pneumonia: A possible cardiovascular complication. G Ital Cardiol (Rome) 2020; 21(6): 417-20.
[http://dx.doi.org/10.1714/3359.33323] [PMID: 32425184]
[25]
Roca E, Lombardi C, Campana M, et al. Takotsubo syndrome associated with COVID-19. Eur J Case Rep Intern Med 2020; 7(5): 001665.
[http://dx.doi.org/10.12890/2020_001665] [PMID: 32399453]
[26]
Giustino G, Croft LB, Oates CP, et al. Takotsubo cardiomyopathy in covid-19. J Am Coll Cardiol 2020; 76(5): 628-9.
[http://dx.doi.org/10.1016/j.jacc.2020.05.068] [PMID: 32517962]
[27]
Taza F, Zulty M, Kanwal A, Grove D. Takotsubo cardiomyopathy triggered by SARS-CoV-2 infection in a critically ill patient. BMJ Case Rep 2020; 13(6): e236561.
[http://dx.doi.org/10.1136/bcr-2020-236561] [PMID: 32540884]
[28]
Kariyanna PT, Chandrakumar HP, Jayarangaiah A, et al. Apical takotsubo cardiomyopathy in a COVID-19 patient presenting with stroke: A case report and pathophysiologic insights. Am J Med Case Rep 2020; 8(10): 350-7.
[http://dx.doi.org/10.12691/ajmcr-8-10-8] [PMID: 32704530]
[29]
Solano-López J, Sánchez-Recalde A, Zamorano JL. SARS-CoV-2, a novel virus with an unusual cardiac feature: Inverted takotsubo syndrome. Eur Heart J 2020; 41(32): 3106.
[http://dx.doi.org/10.1093/eurheartj/ehaa390] [PMID: 32391885]
[30]
Sattar Y, Connerney M, Ullah W, et al. COVID-19 presenting as takotsubo cardiomyopathy complicated with atrial fibrillation. Int J Cardiol Heart Vasc 2020; 29: 100580.
[http://dx.doi.org/10.1016/j.ijcha.2020.100580] [PMID: 32685662]
[31]
Tsao CW, Strom JB, Chang JD, Manning WJ. COVID-19-associated stress (takotsubo) cardiomyopathy. Circ Cardiovasc Imaging 2020; 13(7): e011222.
[http://dx.doi.org/10.1161/CIRCIMAGING.120.011222] [PMID: 32673494]
[32]
Dweck MR, Bularga A, Hahn RT, et al. Global evaluation of echocardiography in patients with COVID-19. Eur Heart J Cardiovasc Imaging 2020; 21(9): 949-58.
[http://dx.doi.org/10.1093/ehjci/jeaa178] [PMID: 32556199]
[33]
Pasqualetto MC, Secco E, Nizzetto M, et al. Stress cardiomyopathy in COVID-19 disease. Eur J Case Rep Intern Med 2020; 7(6): 001718.
[PMID: 32523926]
[34]
Sala S, Peretto G, Gramegna M, et al. Acute myocarditis presenting as a reverse takotsubo syndrome in a patient with SARS-CoV-2 respiratory infection. Eur Heart J 2020; 41(19): 1861-2.
[http://dx.doi.org/10.1093/eurheartj/ehaa286] [PMID: 32267502]
[35]
Faqihi F, Alharthy A, Alshaya R, et al. Reverse takotsubo cardiomyopathy in fulminant COVID-19 associated with cytokine release syndrome and resolution following therapeutic plasma exchange: A case-report. BMC Cardiovasc Disord 2020; 20(1): 389.
[http://dx.doi.org/10.1186/s12872-020-01665-0] [PMID: 32842957]
[36]
Titi L, Magnanimi E, Mancone M, et al. Fatal Takotsubo syndrome in critical COVID-19 related pneumonia. Cardiovasc Pathol 2021; 51: 107314.
[http://dx.doi.org/10.1016/j.carpath.2020.107314] [PMID: 33259936]
[37]
Van Osch D, Asselbergs FW, Teske AJ. Takotsubo cardiomyopathy in COVID-19: A case report. Haemodynamic and therapeutic considerations. Eur Heart J Case Rep 2020; 4(FI1): 1-6.
[http://dx.doi.org/10.1093/ehjcr/ytaa271] [PMID: 33437922]
[38]
Hegde S, Khan R, Zordok M, Maysky M. Characteristics and outcome of patients with COVID-19 complicated by takotsubo cardiomyopathy: Case series with literature review. Open Heart 2020; 7(2): e001360.
[http://dx.doi.org/10.1136/openhrt-2020-001360] [PMID: 33020258]
[39]
Bottiroli M, De Caria D, Belli O, et al. Takotsubo syndrome as a complication in a critically ill COVID-19 patient. ESC Heart Fail 2020; 7(6): 4297-300.
[http://dx.doi.org/10.1002/ehf2.12912] [PMID: 32886428]
[40]
Gomez JMD, Nair G, Nanavaty P, Rao A, Marinescu K, Suboc T. COVID-19-associated takotsubo cardiomyopathy. BMJ Case Rep 2020; 13(12): e236811.
[http://dx.doi.org/10.1136/bcr-2020-236811] [PMID: 33310830]
[41]
Bernardi N, Calvi E, Cimino G, et al. COVID-19 pneumonia, takotsubo syndrome, and left ventricle thrombi. JACC Case Rep 2020; 2(9): 1359-64.
[http://dx.doi.org/10.1016/j.jaccas.2020.06.008] [PMID: 32835280]
[42]
Panchal A, Kyvernitakis A, Biederman R. An interesting case of COVID-19 induced reversed takotsubo cardiomyopathy and insight on cardiac biomarkers. Cureus 2020; 12(11): e11296.
[http://dx.doi.org/10.7759/cureus.11296] [PMID: 33282573]
[43]
Fujisaki T, Kassim F, Kassim G, Bandyopadhyay D, Singh V, Kim B. Biventricular takotsubo syndrome with COVID-19 in an asian male. J Cardiol Cases 2021; 24(1): 6-9.
[http://dx.doi.org/10.1016/j.jccase.2020.11.017] [PMID: 33262862]
[44]
Kong N, Singh N, Mazzone S, Burkhart R, Anchan R, Blair J. Takotsubo syndrome presenting as cardiogenic shock in patients with COVID-19: A case series and review of current literature. Cardiovasc Revasc Med 2021; 28S: 50-3.
[http://dx.doi.org/10.1016/j.carrev.2021.01.017] [PMID: 33516638]
[45]
Sánchez-Recalde Á, Solano-López J, Miguelena-Hycka J, Martín-Pinacho JJ, Sanmartín M, Zamorano JL. COVID-19 and cardiogenic shock. Different cardiovascular presentations with high mortality. Rev Esp Cardiol (Engl Ed) 2020; 73(8): 669-72.
[http://dx.doi.org/10.1016/j.rec.2020.04.012] [PMID: 32499016]
[46]
Chitturi KR, Thacker S, Al-Saadi MA, Kassi M. Successful treatment of acute heart failure in COVID-19-induced cytokine storm with tocilizumab: A case report. Eur Heart J Case Rep 2020; 4(FI1): 1-6.
[http://dx.doi.org/10.1093/ehjcr/ytaa188] [PMID: 33089052]
[47]
Bapat A, Maan A, Heist EK. Stress-induced cardiomyopathy secondary to COVID-19. Case Rep Cardiol 2020; 2020: 8842150.
[http://dx.doi.org/10.1155/2020/8842150] [PMID: 32934848]
[48]
Mishra AK, Dai Q, Sahu KK, ElMeligy A. Atypical takotsubo cardiomyopathy in COVID-19. Am J Med Sci 2021; 362(5): e41-2.
[http://dx.doi.org/10.1016/j.amjms.2021.01.024] [PMID: 34446260]
[49]
Torabi AJ, Villegas-Galaviz J, Guglin M, Frick K, Rao R. Cardiogenic shock following cardiac tamponade and takotsubo in COVID-19. Future Cardiol 2021; 17(4): 631-5.
[http://dx.doi.org/10.2217/fca-2020-0115] [PMID: 33078963]
[50]
Bhattacharyya PJ, Attri PK, Farooqui W. Takotsubo cardiomyopathy in early term pregnancy: A rare cardiac complication of SARS-CoV-2 infection. BMJ Case Rep 2020; 13(9): e239104.
[http://dx.doi.org/10.1136/bcr-2020-239104] [PMID: 32988978]
[51]
Namburu L, Bhogal SS, Ramu VK. COVID-19-induced takotsubo cardiomyopathy with concomitant pulmonary embolism. Cureus 2021; 13(10): e18693.
[http://dx.doi.org/10.7759/cureus.18693] [PMID: 34659930]
[52]
Hoepler W, Traugott MT, Christ G, et al. Clinical and angiographic features in three COVID-19 patients with takotsubo cardiomyopathy. Case report. SN Compr Clin Med 2021; 3(1): 263-8.
[http://dx.doi.org/10.1007/s42399-020-00683-5] [PMID: 33426474]
[53]
Oséas JM, Oliveira WS, Oliveira BA, Miranda JM, Barros RGV, Oliveira NR. Takotsubo syndrome as a complication of mild covid-19: A case report. Int J Cardiovasc Sci 2021.
[http://dx.doi.org/10.36660/ijcs.20200398]
[54]
Hamanaka A, Kono A, Urase Y, et al. A case of takotsubo cardiomyopathy associated with COVID-19 pneumonia: 99mTc tetrofosmin and cardiac MRI. Jap Arch Cases Conf Clin Nuclear Med 2021; 3: 1-8.
[http://dx.doi.org/10.32291/nmj.3.0_1]
[55]
Lyon AR, Citro R, Schneider B, et al. Pathophysiology of takotsubo syndrome: JACC state-of-the-art review. J Am Coll Cardiol 2021; 77(7): 902-21.
[http://dx.doi.org/10.1016/j.jacc.2020.10.060] [PMID: 33602474]
[56]
Amin HZ, Amin LZ, Pradipta A. Takotsubo cardiomyopathy: A brief review. J Med Life 2020; 13(1): 3-7.
[PMID: 32341693]
[57]
Gianni M, Dentali F, Grandi AM, Sumner G, Hiralal R, Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: A systematic review. Eur Heart J 2006; 27(13): 1523-9.
[http://dx.doi.org/10.1093/eurheartj/ehl032] [PMID: 16720686]
[58]
Singh S, Desai R, Gandhi Z, et al. Takotsubo syndrome in patients with covid-19: A systematic review of published cases. SN Compr Clin Med 2020; 2(11): 2102-8.
[http://dx.doi.org/10.1007/s42399-020-00557-w] [PMID: 33043251]
[59]
Ghadri JR, Wittstein IS, Prasad A, et al. International expert consensus document on takotsubo syndrome (Part II): Diagnostic workup, outcome, and management. Eur Heart J 2018; 39(22): 2047-62.
[http://dx.doi.org/10.1093/eurheartj/ehy077] [PMID: 29850820]
[60]
Fanaroff AC, Garcia S, Giri J. Myocardial infarction during the COVID-19 pandemic. JAMA 2021; 326(19): 1916-8.
[http://dx.doi.org/10.1001/jama.2021.19608] [PMID: 34714324]
[61]
Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA covid-19 vaccine. N Engl J Med 2020; 383(27): 2603-15.
[http://dx.doi.org/10.1056/NEJMoa2034577] [PMID: 33301246]
[62]
Fearon C, Parwani P, Gow-Lee B, Abramov D. Takotsubo syndrome after receiving the COVID-19 vaccine. J Cardiol Cases 2021; 24(5): 223-6.
[http://dx.doi.org/10.1016/j.jccase.2021.08.012] [PMID: 34539938]
[63]
Toida R, Uezono S, Komatsu H, et al. Takotsubo cardiomyopathy after vaccination for coronavirus disease 2019 in a patient on maintenance hemodialysis. CEN Case Rep 2021; 1-5.
[PMID: 34731486]

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