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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946


Modified Risk Tobacco Products and Cardiovascular Repair: Still Very “Smoky”

Author(s): Claudia Cozzolino, Vittorio Picchio, Erica Floris, Francesca Pagano, Wael Saade, Mariangela Peruzzi, Giacomo Frati and Isotta Chimenti*

Volume 18, Issue 4, 2023

Published on: 27 August, 2022

Page: [440 - 444] Pages: 5

DOI: 10.2174/1574888X17666220802142532


Smoking habits represent a cardiovascular risk factor with a tremendous impact on health. Other than damaging differentiated and functional cells of the cardiovascular system, they also negatively affect reparative mechanisms, such as those involved in cardiac fibrosis and in endothelial progenitor cell (EPC) activation. In recent years, alternative smoking devices, dubbed modified tobacco risk products (MRPs), have been introduced, but their precise impact on human health is still under evaluation. Also, they have not been characterized yet about the possible negative effects on cardiovascular reparative and regenerative cells, such as EPCs or pluripotent stem cells. In this perspective, we critically review the still scarce available data on the effects of MRPs on molecular and cellular mechanisms of cardiovascular repair and regeneration.

Keywords: Endothelial progenitor cells, pluripotent stem cells, electronic cigarettes, modified risk products, cardiac fibrosis, cardiovascular regeneration.

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