Title:Comparative Analysis of the Pre- and Post-Medication Effects of Antipsychotic
Agents on the Blood-Based Oxidative Stress Biomarkers in Patients
with Schizophrenia: A Meta-Analysis
Volume: 21
Issue: 2
Author(s): Mi Yang*, Chunzhi Wang, Guocheng Zhao, Di Kong, Liju Liu, Shuai Yuan, Wei Chen, Can Feng and Zezhi Li*
Affiliation:
- Department of Psychiatry, The Fourth People's Hospital of Chengdu, Chengdu, China
- Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou
Medical University, Guangzhou, China
- Department of Psychiatry, Guangdong Engineering Technology Research
Center for Translational Medicine of Mental Disorders, Guangzhou, China
Keywords:
Schizophrenia, antipsychotics, oxidative stress, antioxidants, typical antipsychotics, atypical antipsychotic.
Abstract:
Objective: Studies have shown that oxidative stress (OS) is related to the pathophysiology
of schizophrenia (SCZ), but whether antipsychotics can induce OS has not been investigated
well. Moreover, antipsychotics have differential effects on the OS level modulation, i.e., different
types of antipsychotics have different effects on the cellular antioxidants or pro-oxidants.
Methods: We followed the Preferred Reporting Items for Systematic Review and Meta-Analysis
(PRISMA) guidelines and investigated the OS indicators including both enzymatic and nonenzymatic
markers, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase
(GPx), malondialdehyde (MDA), glutathione (GSH), vitamin C, etc., of SCZ patients at baseline
and follow-up of mono-medication.
Results: Twenty studies met the inclusion criteria, with a total of 1162 patients enrolled at baseline,
and 1105 patients completed the follow-up. OS markers were changed after a period of antipsychotic
treatment in SCZ patients. The GPx activity and MDA level decreased in the whole blood
(P<0.05), also the serum MDA level decreased (P<0.05). For the first-episode SCZ patients, the activity
of GPx and the level of MDA decreased, while the level of vitamin C increased (all P<0.05).
The levels of MDA in patients receiving atypical antipsychotics decreased (P<0.05), while the level
of GSH in patients with typical antipsychotics decreased (P=0.05).
Conclusion: Antipsychotic medication may cause changes in the levels of OS markers in different
blood samples of SCZ patients. However, the available studies might not be sufficient to reveal the underlying
facts accurately due to the poor quality of experimental designs in the published literature.
