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Current Nanomedicine

Editor-in-Chief

ISSN (Print): 2468-1873
ISSN (Online): 2468-1881

Review Article

Nanogel Development and its Application in Transdermal Drug Delivery System

Author(s): Sachin S. Gaikwad*, Nisarga V. Akalade and Kishor S. Salunkhe

Volume 12, Issue 2, 2022

Published on: 12 September, 2022

Page: [126 - 136] Pages: 11

DOI: 10.2174/2468187312666220630152606

Price: $65

Abstract

Background: Nanogels are hydrophilic polymer networks that range in size from 20 to 200 nanometers. Polymer is used to make nanogels, which can be obtained from natural or manufactured sources. Nanogels can deliver peptides, antigens, carbohydrates, oligonucleotides, proteins, and genes, among other things. These nanogels also provide inorganic materials, such as silver nanoparticles and quantum dots. Both solid and liquid nanogels have the same properties. These nanogels penetrate the stratum corneum more effectively than conventional gels. Dermatology and cosmetology have both experimented with nanoscale technology.

Objective: The medication can penetrate the stratum corneum through a variety of routes. One of the ways lipids can infiltrate the skin membrane is through the transcellular route. Cream, gel, ointment, lotion, thin-film, and foams are among the topical preparations used. Nanogels are categorised into two types: those that respond to stimuli and those that cross-link. For the manufacture of nanogels, numerous polymers of synthetic, natural, or semisynthetic origin are commonly employed. Nanoprecipitation, emulsion polymerization, and dispersion polymerization are all ways to make these nanogels. These nanogels are rarely released by diffusion mechanism employing the Fick’s law.

Conclusion: The nano gel is a new advanced technology that allows to improve drug molecule penetration in the stratum corneum. If poorly soluble and permeable medications are administered through this nanogel technology, their solubility and permeability will be improved.

Keywords: Skin anatomy, polymer, nanoparticles, penetration pathway, drug delivery system, nano gel.

Graphical Abstract

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