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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Review Article

The Protective Role of Grape Seed in Obesity and Lipid Profile: An Updated Narrative Overview of Preclinical and Clinical Studies

Author(s): Marjan Talebi, Hadi Esmaeeli, Selen İlgün, Mohsen Talebi, Tahereh Farkhondeh, Gaurav Mishra and Saeed Samarghandian*

Volume 23, Issue 1, 2023

Published on: 13 September, 2022

Page: [46 - 62] Pages: 17

DOI: 10.2174/1871530322666220630091859

Price: $65

Abstract

Obesity and dyslipidemia are common disorders universally. According to the acquired outcomes of recent studies, dietary supplementations which have great content of phenolic compounds exert protective effects against obesity and dyslipidemia. Grape [Vitis vinifera] seeds are considered attractive sources of phenolic compounds with anti-oxidative stress and anti-inflammatory effects. There are also various experimental studies describing hepatoprotective, neuroprotective, anti-aging, cardioprotective, and anti-carcinogenic effects of polyphenols isolated from grape seed, highlighting the therapeutic and biological aspects of proanthocyanidins. The present review article first discusses pharmacological, botanical, toxicological, and phytochemical characteristics of Vitis vinifera seeds and afterward designates the protective properties which are attributed to the intake of grape seeds in obesity and hyperlipidemia. Overall valuable and updated findings of this study display that polyphenol of grape seeds has meaningful impacts on the regulation of lipid profile levels and management of obesity.

Keywords: Obesity, dyslipidemia, Vitis vinifera, grape seed, proanthocyanidins, hyperlipidemia, adipocyte, natural products.

Graphical Abstract
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