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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

Overview of Stem Cell Therapy in Intervertebral Disc Disease: Clinical Perspective

Author(s): Ayshe Hajiesmailpoor, Omid Mohamadi, Gholamreza Farzanegan, Payam Emami and Masoud Ghorbani*

Volume 18, Issue 5, 2023

Published on: 01 September, 2022

Page: [595 - 607] Pages: 13

DOI: 10.2174/1574888X17666220628123912

Price: $65

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Abstract

Intervertebral Disc Degeneration (IDD) is recognized as an aging process, an important and most common pathological condition caused by an imbalance of anabolic and catabolic metabolisms in the Intervertebral Disc (IVD), and leads to changes in the Extracellular Matrix (ECM), impaired metabolic regulation of Nucleus Pulposus (NP), and increased oxidative stress. IDD is mostly associated with pain in the back and neck, which is referred to as a type of disability. Pharmacological and surgical interventions are currently used to treat IDD, but evidence has shown that these interventions do not have the ability to inhibit the progression of IDD and restore IVD function because IVD lacks the intrinsic capacity for regeneration. Thus, therapies that rely on a degenerative cell repair mechanism may be a viable alternative strategy. Biological interventions have been assessed by attempting to regenerate IVD by restoring ECM and cellular function. Over the past decade, stem cell-based therapies have been considered, and promising results have been obtained in various studies. Given this, we reviewed clinical trials and preliminary studies of biological disc repair with a focus on stem cell therapy-based therapies.

Keywords: Intervertebral disc degeneration, intervertebral disc, stem cell therapy, biological therapy, clinical trial, disc regeneration.

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Graphical Abstract

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