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Current Cardiology Reviews

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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

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Review Article

Heart Failure And Type 2 Diabetes Mellitus: Neurohumoral, Histological And Molecular Interconnections

Author(s): A. Ushakov, V. Ivanchenko* and A. Gagarina

Volume 19, Issue 2, 2023

Published on: 26 August, 2022

Article ID: e170622206132 Pages: 16

DOI: 10.2174/1573403X18666220617121144

Price: $65

Abstract

Heart failure (HF) is a global healthcare burden and a leading cause of morbidity and mortality worldwide. Type 2 diabetes mellitus (T2DM) appears to be one of the major risk factors that significantly worsen HF prognosis and increase the risk of fatal cardiovascular outcomes. Despite a great knowledge of pathophysiological mechanisms involved in HF development and progression, hospitalization rates in patients with HF and concomitant T2DM remain elevated. In this review, we discuss the complex interplay between systemic neurohumoral regulation and local cardiac mechanisms participating in myocardial remodeling and HF development in T2DM with special attention to cardiomyocyte energy metabolism, mitochondrial function and calcium metabolism, cardiomyocyte hypertrophy and death, extracellular matrix remodeling.

Keywords: Heart failure, type 2 diabetes mellitus, pathophysiology, cardiac remodeling, glucotoxicity, lipotoxicity.

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