Title:New Bicyclic Lactone by Biotransformation of β-caryophyllene using
Aspergillus niger
Volume: 19
Issue: 12
Author(s): Qutaiba Al-Dulaimi, Mohammad Yasin Mohammad*, Manal Al-Najdawi, Yusuf M. Al-Hiari, Haroon M. Haniffa and M. Iqbal Choudhary
Affiliation:
- Michael Sayegh Faculty of Pharmacy, Aqaba University
of Technology, Aqaba-11191, Jordan
Keywords:
β-Caryophyllene, Aspergillus niger, fungal transformation, demethylation, oxidation, metabolite.
Abstract: Microbial transformation of β-caryophyllene (1) by suspended cell cultures of the plant
pathogen fungus Aspergillus niger, resulted in the production of one major metabolite. This metabolite
was identified as (3aR,11aS, E)-9-methyl-4-methylene-3a,4,7,10,11,11a-hexahydro-2H-furo[3,2-
c]oxecine-2,6(3H)-dione (2), by different spectroscopic methods. Metabolite 2 was found to be a new
compound. The proposed pathway for the synthesis of compound 2 was also explained.
