Congenital Bleeding Disorders and COVID-19 - An Emphasis on the Role
of Thrombosis as One of the Main Causes of Morbidity and Mortality in
COVID-19

Akbar      Dorgalaleh; Fatemeh      Narouei; Mansur      Asadi; Hassan   Morovati   Khamsi; Mohammad   Saeed   Gholami

Abstract

A turbulent coagulation system is a prominent feature of Coronavirus Disease 2019 (COVID-19), with venous thromboembolism (VTE) a leading cause of death. Our hypothesis is that patients with inherited hypocoagulability, like congenital bleeding disorders (CBD), enjoy a protective effect against COVID-19-induced hypercoagulability and related fatal consequences. Our primary and follow-up observations revealed this effect, at least among patients with moderate to severe congenital bleeding disorders, particularly coagulation factor deficiencies. Theoretically, patients with inherited hypocoagulobility have only a potential protective effect against COVID-19-related hypercoagulability. Yet the lower rate of morbidity and mortality in patients with CBDs suggests that hypercoagulability and thrombotic events are the main cause of death in COVID-19. Therefore, appropriate and timely administration of anticoagulants could significantly decrease the rate of morbidity and mortality in COVID-19.

Keywords: COVID-19, hypercoagulability, hypocoagulability, thrombosis, congenital bleeding disorders, SARS-CoV-2.

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DOI https://dx.doi.org/10.2174/1871529X22666220614090005	Print ISSN 1871-529X
Publisher Name Bentham Science Publisher	Online ISSN 2212-4063

Cardiovascular & Hematological Disorders-Drug Targets

Congenital Bleeding Disorders and COVID-19 - An Emphasis on the Role of Thrombosis as One of the Main Causes of Morbidity and Mortality in COVID-19

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