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Cardiovascular & Hematological Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Research Article

Antihypertensive Activity of Prunus armeniaca in Hypertensive Rats

Author(s): Ismail Bouadid, Mourad Akdad and Mohamed Eddouks*

Volume 21, Issue 1, 2023

Published on: 09 September, 2022

Page: [20 - 30] Pages: 11

DOI: 10.2174/1871525720666220613164559

Price: $65

Abstract

Aims: The goal of this work was to evaluate the antihypertensive activity of Prunus armeniaca.

Background: Prunus armeniaca is known for its beneficial medicinal properties.

Objective: This study aimed to evaluate the effect of the aqueous extract of Prunus armeniaca L. (P. armeniaca) leaves (PAAE) on arterial blood pressure in normotensive and hypertensive rats.

Materials and Methods: In the in vivo examination, N-omega-Nitro-L-arginine methyl ester hydrochloride( L-NAME)-induced hypertensive and normotensive rats received PAAE (160 and 100 mg/kg) orally for the acute experiment spanning 6 hours and for seven days for the subchronic treatment; their blood pressure parameters were also evaluated. In the in vitro experiment, isolated intact thoracic aortic rings were precontracted with KCl (80 mM) and epinephrine (EP) (10 μM), and vascular dilatation was assessed.

Results: PAAE lowered blood pressure parameters in L-NAME-induced hypertensive without affecting normotensive rats following oral administration, suggesting that PAAE possesses an antihypertensive effect. In addition, PAAE (0.25-1 mg/mL) revealed a vasorelaxant effect in thoracic aortic rings precontracted by EP (10 μM), and this effect was especially reduced in the presence of glibenclamide or nifedipine. However, PAAE (0.25-1 mg/mL) had only a minimal vasorelaxant effect on thoracic aortic rings precontracted by KCl (80 mM).

Conclusion: The results demonstrate that the P. armeniaca aqueous extract possesses potent antihypertensive and vasorelaxant activity, and its vasorelaxant activity seems to be mediated through the opening of ATP-sensitive K+ channels and inhibition of L-type calcium channels.

Keywords: Prunus armeniaca L., hypertension, vasorelaxant, L-NAME, K+ channels, calcium channels.

Graphical Abstract


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