Title:Lymphatic Regulation in Tissue Repair and Regeneration: Recent
Advances and Future Perspective
Volume: 18
Issue: 6
Author(s): Yihua Bei, Jianyun Liu and Junjie Xiao*
Affiliation:
- Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s
Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China
- Cardiac Regeneration and
Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of
Life Science, Shanghai University, Shanghai 200444, China
Keywords:
Lymphatic vessels, tissue repair and regeneration, tissue homeostasis, immunomodulation, proliferation, stem cell niche.
Abstract: Lymphatic vasculature plays essential role in interstitial tissue uptake, immune cell transport
and dietary lipid absorption. Increasing evidence has demonstrated the contribution of lymphangiogenesis
to tissue repair and regeneration, which is associated with multiple factors such as improved tissue homeostasis,
inflammation resolution, and immunomodulation effects. Meanwhile, lymphangiogenesis has the
potential to regulate cell growth and proliferation through paracrine effects. Lymphatic vessels can also
be important components of the stem cell niche and participate in regulating stem cell quiescency or activity.
In perspective, the functions and mechanisms of lymphatic vessels in tissue repair and regeneration
deserve further investigation. Novel strategies to stimulate lymphangiogenesis by using pharmacological,
genetic, and lymphatic tissue engineering will be prospective to promote tissue repair and regeneration.
