Login Register Cart 0
Review Article

丁香酚治疗脑部疾病治疗潜力的临床前循证综述

卷 23, 期 5, 2023

发表于: 27 July, 2022

页: [390 - 400] 页: 11

弟呕挨: 10.2174/1566524022666220525145521

价格: $65

conference banner
摘要

焦虑、压力、抑郁、阿尔茨海默病、帕金森病等脑部疾病和病症的发病率越来越高，已经变得严重。尽管研究人员花费了大量时间检查这些疾病并提供许多益处，但可用于治疗这些疾病的药物仍然有限。丁香酚是存在于许多植物和草药中的饮食成分，具有多种健康益处。在各种临床前研究中，丁香酚对各种脑部疾病提供了显着的保护作用。因此，在饮食中加入丁香酚可以对抗各种疾病并确保健康的生活。考虑到丁香酚的丰硕影响，本文重点综述了丁香酚用于脑部疾病，并总结了丁香酚的有益特性及其在治疗各种脑部疾病中的作用。

关键词: 丁香酚，脑部疾病，帕金森病，阿尔茨海默病，压力，镇痛，癫痫，抑郁症。

« Previous Next »
[1]
Zahiruddin S, Basist P, Parveen A, Parveen R, Khan W. Gaurav; Ahmad, S. Ashwagandha in brain disorders: A review of recent developments. J Ethnopharmacol 2020; 257: 112876.
[2]
Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RAJO, Bromberg E, de Vries EFJ. Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation. Mol Neurobiol 2019; 56(5): 3295-312.
[http://dx.doi.org/10.1007/s12035-018-1283-6] [PMID: 30117106]
[3]
Henriques JF, Serra D, Dinis TCP, Almeida LM. The anti-neuroinflammatory role of anthocyanins and their metabolites for the prevention and treatment of brain disorders. Int J Mol Sci 2020; 21(22): 1-31.
[http://dx.doi.org/10.3390/ijms21228653] [PMID: 33212797]
[4]
Singh V, Panwar R. In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain. Mol Cell Biochem 2014; 388(1-2): 61-74.
[http://dx.doi.org/10.1007/s11010-013-1899-9] [PMID: 24292926]
[5]
Barboza JN, da Silva Maia Bezerra Filho C, Silva RO, Medeiros JVR, de Sousa DP. An overview on the anti-inflammatory potential and antioxidant profile of eugenol. Oxid Med Cell Longev 2018; 2018: 3957262.
[http://dx.doi.org/10.1155/2018/3957262]
[6]
Zhang P, Zhang E, Xiao M, Chen C, Xu W. Study of anti-inflammatory activities of α-D-glucosylated eugenol. Arch Pharm Res 2013; 36(1): 109-15.
[http://dx.doi.org/10.1007/s12272-013-0003-z] [PMID: 23325490]
[7]
Fujisawa S, Atsumi T, Kadoma Y, Sakagami H. Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity. Toxicology 2002; 177(1): 39-54.
[http://dx.doi.org/10.1016/S0300-483X(02)00194-4] [PMID: 12126794]
[8]
Hemaiswarya S, Doble M. Synergistic interaction of eugenol with antibiotics against gram negative bacteria. Phytomedicine 2009; 16(11): 997-1005.
[http://dx.doi.org/10.1016/j.phymed.2009.04.006] [PMID: 19540744]
[9]
Kim HM, Lee EH, Kim CY, et al. Antianaphylactic properties of eugenol. Pharmacol Res 1997; 36(6): 475-80.
[http://dx.doi.org/10.1006/phrs.1997.0256] [PMID: 9508673]
[10]
Baskaran Y, Periyasamy V, Venkatraman AC. Corrigendum to “Investigation of antioxidant, anti-inflammatory and dnaprotective properties of eugenol in thioacetamide-induced liver injury in rats” Toxicology 268(3): 204-12.
[http://dx.doi.org/10.1016/j.tox.2009.12.018]
[11]
Moreira Vasconcelos CF, da Cunha Ferreira NM, Hardy Lima Pontes N, et al. Eugenol and its association with levodopa in 6-hydroxydopamine-induced hemiparkinsonian rats: Behavioural and neurochemical alterations. Basic Clin Pharmacol Toxicol 2020; 127(4): 287-302.
[http://dx.doi.org/10.1111/bcpt.13425] [PMID: 32353201]
[12]
Rodrigues TG, Fernandes A Jr, Sousa JPB, Bastos JK, Sforcin JM. In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Nat Prod Res 2009; 23(4): 319-26.
[http://dx.doi.org/10.1080/14786410802242679] [PMID: 19296372]
[13]
Hui Q, Ammeter E, Liu S, et al. Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells. J Anim Sci 2020; 98(8): 98.
[http://dx.doi.org/10.1093/jas/skaa245] [PMID: 32735667]
[14]
Pinto E, Vale-Silva L, Cavaleiro C, Salgueiro L. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. J Med Microbiol 2009; 58(Pt 11): 1454-62.
[http://dx.doi.org/10.1099/jmm.0.010538-0] [PMID: 19589904]
[15]
Yagura S, Onimaru H, Kanzaki K, Izumizaki M. Inhibitory effects of eugenol on putative nociceptive response in spinal cord preparation isolated from neonatal rats. Exp Brain Res 2018; 236(6): 1767-74.
[http://dx.doi.org/10.1007/s00221-018-5254-y] [PMID: 29654351]
[16]
Barbas LAL, Torres MF, da Costa BMPA, et al. Eugenol induces body immobilization yet evoking an increased neuronal excitability in fish during short-term baths. Aquat Toxicol 2021; 231: 105734.
[http://dx.doi.org/10.1016/j.aquatox.2020.105734] [PMID: 33385846]
[17]
Marchese A, Barbieri R, Coppo E, et al. Antimicrobial activity of eugenol and essential oils containing eugenol: A mechanistic viewpoint. Crit Rev Microbiol 2017; 43(6): 668-89.
[http://dx.doi.org/10.1080/1040841X.2017.1295225] [PMID: 28346030]
[18]
Ashrafudoulla M, Mizan MFR, Ha AJ. won; Park SH, Ha S do. Antibacterial and antibiofilm mechanism of eugenol against antibiotic resistance vibrio parahaemolyticus. Food Microbiol 2020; 91: 103500.
[19]
Pessoa LM, Morais SM, Bevilaqua CML, Luciano JHS. Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus. Vet Parasitol 2002; 109(1-2): 59-63.
[http://dx.doi.org/10.1016/S0304-4017(02)00253-4] [PMID: 12383625]
[20]
Gülçin İ. Antioxidant activity of eugenol: A structure-activity relationship study. J Med Food 2011; 14(9): 975-85.
[http://dx.doi.org/10.1089/jmf.2010.0197] [PMID: 21554120]
[21]
Magalhães CB, Casquilho NV, Machado MN, et al. The anti-inflammatory and anti-oxidative actions of eugenol improve lipopolysaccharide-induced lung injury. Respir Physiol Neurobiol 2019; 259: 30-6.
[http://dx.doi.org/10.1016/j.resp.2018.07.001] [PMID: 29997055]
[22]
Prasad SN. Evidence of acrylamide induced oxidative stress and neurotoxicity in Drosophila melanogaster - its amelioration with spice active enrichment: Relevance to neuropathy. Neurotoxicology 2012; 33(5): 1254-64.
[http://dx.doi.org/10.1016/j.neuro.2012.07.006] [PMID: 22841601]
[23]
Nikbin S, Derakhshideh A, Kanozi F, et al. Combination effect of exercise training and eugenol supplementation on the hippocampus apoptosis induced by chlorpyrifos. Mol Biol Rep 2020; 47(8): 5985-96.
[http://dx.doi.org/10.1007/s11033-020-05672-4] [PMID: 32780254]
[24]
Ahmad N, Ahmad R, Alam MA, Ahmad FJ. Quantification and brain targeting of eugenol-loaded surface modified nanoparticles through intranasal route in the treatment of cerebral ischemia. Drug Res 2018; 68(10): 584-95.
[http://dx.doi.org/10.1055/a-0596-7288] [PMID: 29669380]
[25]
Said MM. The protective effect of eugenol against gentamicin-induced nephrotoxicity and oxidative damage in rat kidney. Fundam Clin Pharmacol 2011; 25(6): 708-16.
[http://dx.doi.org/10.1111/j.1472-8206.2010.00900.x] [PMID: 21105912]
[26]
Manikandan P, Vinothini G, Vidya Priyadarsini R, Prathiba D, Nagini S. Eugenol inhibits cell proliferation via NF-κB suppression in a rat model of gastric carcinogenesis induced by MNNG. Invest New Drugs 2011; 29(1): 110-7.
[http://dx.doi.org/10.1007/s10637-009-9345-2] [PMID: 19851710]
[27]
Júnior PLDS, Câmara DAD, Costa AS, et al. Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro. Phytomedicine 2016; 23(7): 725-35.
[http://dx.doi.org/10.1016/j.phymed.2016.03.014] [PMID: 27235711]
[28]
Nam H, Kim MM. Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells. Food Chem Toxicol 2013; 55: 106-12.
[http://dx.doi.org/10.1016/j.fct.2012.12.050] [PMID: 23313798]
[29]
Wie MB, Won MH, Lee KH, et al. Eugenol protects neuronal cells from excitotoxic and oxidative injury in primary cortical cultures. Neurosci Lett 1997; 225(2): 93-6.
[http://dx.doi.org/10.1016/S0304-3940(97)00195-X] [PMID: 9147382]
[30]
Kabuto H, Tada M, Kohno M. Eugenol [2-methoxy-4-(2-propenyl)phenol] prevents 6-hydroxydopamine-induced dopamine depression and lipid peroxidation inductivity in mouse striatum. Biol Pharm Bull 2007; 30(3): 423-7.
[http://dx.doi.org/10.1248/bpb.30.423] [PMID: 17329831]
[31]
Pontes KAO, Silva LS, Santos EC, et al. Eugenol disrupts plasmodium falciparum intracellular development during the erythrocytic cycle and protects against cerebral malaria. Biochimica et Biophysica Acta - General Subjects 2021; 1865(3): 129813.
[32]
Adefegha SA, Okeke BM, Oboh G. Antioxidant properties of eugenol, butylated hydroxylanisole, and butylated hydroxyl toluene with key biomolecules relevant to Alzheimer’s diseases-In vitro. J Food Biochem 2021; 45(3): e13276.
[http://dx.doi.org/10.1111/jfbc.13276] [PMID: 32458455]
[33]
National Center for Biotechnology Information. PubChem Compound Summary for CID 3314, Eugenol. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/ Eugenol
[34]
Garabadu D, Sharma M. Eugenol attenuates scopolamine-induced hippocampal cholinergic, glutamatergic, and mitochondrial toxicity in experimental rats. Neurotox Res 2019; 35(4): 848-59.
[http://dx.doi.org/10.1007/s12640-019-0008-6] [PMID: 30737653]
[35]
Jayasingh Chellammal HS, Veerachamy A, Ramachandran D, Gummadi SB, Manan MM, Yellu NR. Neuroprotective effects of 1‘δ-1′-acetoxyeugenol acetate on Aβ(25-35) induced cognitive dysfunction in mice. Biomed Pharmacother 2019; 109: 1454-61.
[http://dx.doi.org/10.1016/j.biopha.2018.10.189] [PMID: 30551397]
[36]
Liu Z, Niu W, Yang X, Wang Y. Effects of combined acupuncture and eugenol on learning-memory ability and antioxidation system of hippocampus in Alzheimer disease rats via olfactory system stimulation. J Tradit Chin Med 2013; 33(3): 399-402.
[http://dx.doi.org/10.1016/S0254-6272(13)60186-7] [PMID: 24024340]
[37]
Said MM, Rabo MMA. Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain. Arh Hig Rada Toksikol 2017; 68(1): 27-37.
[http://dx.doi.org/10.1515/aiht-2017-68-2878] [PMID: 28365674]
[38]
Jeong KH, Lee DS, Kim SR. Effects of eugenol on granule cell dispersion in a mouse model of temporal lobe epilepsy. Epilepsy Res 2015; 115: 73-6.
[http://dx.doi.org/10.1016/j.eplepsyres.2015.06.001] [PMID: 26220380]
[39]
Joushi S, Salmani ME. Effect of eugenol on lithium-pilocarpine model of epilepsy: Behavioral, histological, and molecular changes. Iran J Basic Med Sci 2017; 20(7): 745-52.
[PMID: 28852438]
[40]
Müller M, Pape HC, Speckmann EJ, Gorji A. Effect of eugenol on spreading depression and epileptiform discharges in rat neocortical and hippocampal tissues. Neuroscience 2006; 140(2): 743-51.
[http://dx.doi.org/10.1016/j.neuroscience.2006.02.036] [PMID: 16563641]
[41]
Gao X feng, Liu Q, Qing H, et al. Development of eugenol-loaded submicron emulsion and its antiepileptic effect through regulating the oxidative stress. Int J Pharm 2020; 587.
[42]
Huang CW, Chow JC, Tsai JJ, Wu SN. Characterizing the effects of eugenol on neuronal ionic currents and hyperexcitability. Psychopharmacology 2012; 221(4): 575-87.
[http://dx.doi.org/10.1007/s00213-011-2603-y] [PMID: 22160139]
[43]
Lionnet L, Beaudry F, Vachon P. Intrathecal eugenol administration alleviates neuropathic pain in male Sprague-Dawley rats. Phytother Res 2010; 24(11): 1645-53.
[http://dx.doi.org/10.1002/ptr.3174] [PMID: 21031622]
[44]
Cho JS, Kim TH, Lim JM, Song JH. Effects of eugenol on Na+ currents in rat dorsal root ganglion neurons. Brain Res 2008; 1243: 53-62.
[http://dx.doi.org/10.1016/j.brainres.2008.09.030] [PMID: 18824159]
[45]
Paula-Freire LIG, Molska GR, Andersen ML, Carlini ELDA. Ocimum gratissimum essential oil and its isolated compounds (eugenol and myrcene) reduce neuropathic pain in mice. Planta Med 2016; 82(3): 211-6.
[PMID: 26584457]
[46]
Yano S, Suzuki Y, Yuzurihara M, et al. Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice. Eur J Pharmacol 2006; 553(1-3): 99-103.
[http://dx.doi.org/10.1016/j.ejphar.2006.09.020] [PMID: 17049512]
[47]
Bahramsoltani R, Farzaei MH, Farahani MS, Rahimi R. Phytochemical constituents as future antidepressants: A comprehensive review. Rev Neurosci 2015; 26(6): 699-719.
[http://dx.doi.org/10.1515/revneuro-2015-0009] [PMID: 26146123]
[48]
do Amaral JF, Silva MIG, de Aquino Neto MR, et al. Antidepressant-like effect of bis-eugenol in the mice forced swimming test: Evidence for the involvement of the monoaminergic system. Fundam Clin Pharmacol 2013; 27(5): 471-82.
[http://dx.doi.org/10.1111/j.1472-8206.2012.01058.x] [PMID: 22827775]
[49]
Irie Y, Itokazu N, Anjiki N, Ishige A, Watanabe K, Keung WM. Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus. Brain Res 2004; 1011(2): 243-6.
[http://dx.doi.org/10.1016/j.brainres.2004.03.040] [PMID: 15157811]
[50]
Tao G, Irie Y, Li DJ, Keung WM. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity. Bioorg Med Chem 2005; 13(15): 4777-88.
[http://dx.doi.org/10.1016/j.bmc.2005.04.081] [PMID: 15936201]
[51]
Norte MCB, Cosentino RM, Lazarini CA. Effects of methyl-eugenol administration on behavioral models related to depression and anxiety, in rats. Phytomedicine 2005; 12(4): 294-8.
[http://dx.doi.org/10.1016/j.phymed.2003.12.007] [PMID: 15898707]
[52]
Dhiman P, Malik N, Khatkar A. Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: Synthesis and in silico based study. BMC Chem 2019; 13(1): 38.
[http://dx.doi.org/10.1186/s13065-019-0552-4] [PMID: 31384786]
[53]
Garabadu D, Shah A, Ahmad A, et al. Eugenol as an anti-stress agent: Modulation of hypothalamic-pituitary-adrenal axis and brain monoaminergic systems in a rat model of stress. Stress 2011; 14(2): 145-55.
[http://dx.doi.org/10.3109/10253890.2010.521602] [PMID: 21034296]
[54]
Wang X, Chen Y, Wang Q, et al. Support for natural small-molecule phenols as anxiolytics. Molecules 2017; 22(12): 22.
[http://dx.doi.org/10.3390/molecules22122138] [PMID: 29210995]
[55]
Ma L, Mu Y, Zhang Z, Sun Q. Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury. Restor Neurol Neurosci 2018; 36(5): 659-68.
[http://dx.doi.org/10.3233/RNN-180826] [PMID: 30040768]
[56]
Robin O, Alaoui-Ismaïli O, Dittmar A, Vernet-Maury E. Basic emotions evoked by eugenol odor differ according to the dental experience. A neurovegetative analysis. Chem Senses 1999; 24(3): 327-35.
[http://dx.doi.org/10.1093/chemse/24.3.327] [PMID: 10400451]
[57]
Prasad SN. Neuroprotective efficacy of eugenol and isoeugenol in acrylamide-induced neuropathy in rats: Behavioral and biochemical evidence. Neurochem Res 2013; 38(2): 330-45.
[http://dx.doi.org/10.1007/s11064-012-0924-9] [PMID: 23161090]
[58]
Prasad SN, Bharath MS. Neurorestorative effects of eugenol, a spice bioactive: Evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat. Neurochem Int 2016; 95: 24-36.
[http://dx.doi.org/10.1016/j.neuint.2015.10.012] [PMID: 26519099]
[59]
Guo KF, Dai M, Liu YM, et al. Acute Administration of methyleugenol impairs hippocampus-dependent contextual fear memory and increases anxiety-like behavior in mice. J Agric Food Chem 2020; 68(28): 7490-7.
[http://dx.doi.org/10.1021/acs.jafc.0c01863] [PMID: 32551566]
[60]
Lane BW, Ellenhorn MJ, Hulbert TV, McCarron M. Clove oil ingestion in an infant. Hum Exp Toxicol 1991; 10(4): 291-4.
[http://dx.doi.org/10.1177/096032719101000410] [PMID: 1679654]
[61]
Kabuto H, Yamanushi TT. Effects of zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] and eugenol [2-methoxy-4-(2-propenyl)phenol] on the pathological progress in the 6-hydroxydopamine-induced Parkinson’s disease mouse model. Neurochem Res 2011; 36(12): 2244-9.
[http://dx.doi.org/10.1007/s11064-011-0548-5] [PMID: 21769642]

Rights & Permissions Print Cite
Article Metrics
70
2
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy