Background: How to reduce the radiation dose received from full-body CT scans during the follow-up of lymphoma patients is a concern.
Objective: The aim of the study was to investigate the image quality and radiation dose of reduced-dose full-body computerized tomography (CT) in lymphoma patients during the follow-up.
Methods: 121 patients were included and divided into conventional CT group (group 1, 120-kVp, n = 61) or reduced-dose CT group (group 2, 100-kVp combined dual-energy CT (DECT), n = 60). 140-kVp polychromatic images and 70-keV monochromatic images were reconstructed from DECT. The abdominal virtual non-enhanced (VNE) images were reconstructed from monochromatic images. Two radiologists rated the overall image quality with a five-point scale and graded the depiction of lesions using a four-point scale. The objective image quality was evaluated using image noise, signal-to-noise ratio, and contrast-to-noise ratio. The radiation dose and image quality were compared between the groups.
Results: The comparable subjective image quality was observed between 70-keV and 120-kVp images in the neck, while 120-kVp images showed better objective image quality. 70-keV images showed better objective image quality in the chest. While the subjective image quality of abdominal VNE images was inferior to that of true non-enhanced images, the improved objective image quality was observed in VNE images. In the abdominal arterial phase, similar subjective image quality was observed between the groups. Abdominal 70-keV images in the arterial phase showed improved objective image quality. Similar image quality was obtained in the abdominal venous phase between the groups. The effective radiation dose in group 2 showed a significant reduction.
Conclusion: The application of reduced-dose full-body CT can significantly reduce the radiation dose for lymphoma patients during the follow-up while maintaining or improving the image quality.
Keywords: Tomography, X-ray computed, dual-energy, lymphoma, radiation dose, image quality.
[http://dx.doi.org/10.3322/caac.21590] [PMID: 31912902]
[http://dx.doi.org/10.1007/s12094-015-1394-8] [PMID: 26307754]
[http://dx.doi.org/10.3109/10428194.2015.1094694] [PMID: 26374395]
[http://dx.doi.org/10.6004/jnccn.2011.0048] [PMID: 21550970]
[http://dx.doi.org/10.1371/journal.pone.0192656] [PMID: 29444176]
[http://dx.doi.org/10.1148/radiol.11102217] [PMID: 21493795]
[http://dx.doi.org/10.1177/0036850419892193] [PMID: 31791209]
[http://dx.doi.org/10.2214/AJR.11.6831] [PMID: 22358002]
[http://dx.doi.org/10.1259/bjr.20180013] [PMID: 29658769]
[http://dx.doi.org/10.1007/s10140-019-01687-y] [PMID: 30963313]
[http://dx.doi.org/10.1016/j.ejro.2020.100234] [PMID: 32420413]
[http://dx.doi.org/10.1007/s00330-018-5850-z] [PMID: 30506223]
[http://dx.doi.org/10.1016/j.ejrad.2012.02.019] [PMID: 22565148]
[http://dx.doi.org/10.1007/s00330-020-06657-4] [PMID: 32189051]
[http://dx.doi.org/10.3174/ajnr.A4314] [PMID: 26021623]
[http://dx.doi.org/10.2214/AJR.12.10495] [PMID: 23883207]
[http://dx.doi.org/10.1177/0284185117732806] [PMID: 28927299]
[http://dx.doi.org/10.1007/s00330-010-1964-7] [PMID: 20936520]
[http://dx.doi.org/10.2217/iim.09.5] [PMID: 22308169]
[http://dx.doi.org/10.1259/bjr.20180546] [PMID: 30919651]
[http://dx.doi.org/10.1590/0100-3984.2017.0136] [PMID: 30559555]
[http://dx.doi.org/10.1007/s00330-012-2485-3] [PMID: 22618521]
[http://dx.doi.org/10.1016/j.ejrad.2018.10.026] [PMID: 30392950]
[http://dx.doi.org/10.1016/j.acra.2016.09.002] [PMID: 27769822]
[http://dx.doi.org/10.1148/radiol.11100978] [PMID: 21330561]