Title:Recent Advances in [5+2] Cycloadditions
Volume: 26
Issue: 8
Author(s): Nissy Ann Harry*Ujwaldev Sankuviruthiyil Mohanan
Affiliation:
- Department of Chemistry, Catholicate College, Pathanamthitta. Kerala 689645, India
Keywords:
[5+2] Cycloaddition, vinyl cyclopropanes, heptacycles, oxidopyrylium, vinyl phenols, enantioselectivity, diastereoselectivity.
Abstract: The existence of a seven-membered cyclic core in several natural products and
biomolecules vitalized the research on its synthesis. [5+2] cycloaddition has become a promising
strategy for the construction of seven-membered ring systems by the formation of carboncarbon
bonds in a single step, with strong regioselectivity and stereoselectivity. This review
mainly focuses on recent developments in the area of [5+2] cycloaddition since 2019. Total
synthesis of natural products involving [5+2] cycloaddition as a key step leading to the heptacyclic
core has also been discussed. Synthesis of fused and bridged ring systems via the reactions
involving inter and intramolecular [5+2] cycloadditions like oxidopyrylium-mediated
[5+2] cycloadditions, [5+2] cycloadditions of vinyl cyclopropanes (VCPs), vinyl phenols, etc.
is explained in the review with the latest examples. This review provides a useful guide for
researchers exploring this powerful strategy to create more elegant heptacycles in their future research.