hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal Cord Injury

Title:hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal Cord Injury

Volume: 18 Issue: 4

Author(s): Xiaofeng Du, Asiamah Ernest Amponsah, Desheng Kong, Jingjing He, Zhenhuan Ma, Jun Ma*Huixian Cui*

Affiliation:

• Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China
• Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China
• Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China

• Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China
• Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China
• Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China

Keywords: Spinal cord injury, hiPSC, neural stem cell, neural progenitor cell, transplantation, neuroprotective effects.

Abstract: Spinal cord injury (SCI) is a catastrophic event that incurs substantial personal and social costs. The complex pathophysiology associated with SCI often limits the regeneration of nerve tissue at the injured site and leads to permanent nerve damage. With advances in stem cell biology, the field of regenerative medicine offers the hope of solving this challenging problem. Neural stem/progenitor cells (NSPCs) possess nerve regenerative and neuroprotective effects, and transplanting NSPCs in their optimized form into an injured area holds promising therapeutic potential for SCI. In this review, we summarize the advantages and disadvantages of NSPCs derived from different sources while highlighting the utility of NSPCs derived from induced pluripotent stem cells, an NSPC source with superior advantages, according to data from in vivo animal models and the latest clinical trials.

Cite this article as:

Du Xiaofeng, Amponsah Ernest Asiamah, Kong Desheng, He Jingjing, Ma Zhenhuan, Ma Jun*, Cui Huixian*, hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal Cord Injury, Current Stem Cell Research & Therapy 2023; 18(4) . https://dx.doi.org/10.2174/1574888X17666220509222520