Title:Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review
Volume: 22
Issue: 4
Author(s): Mitra-Sadat Sadat-Shirazi, Mahsa Sadeghi-Adl, Ardeshir Akbarabadi, Ghorbangol Ashabi, Azarakhsh Mokri and Mohammad-Reza Zarrindast*
Affiliation:
- Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
- Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
- Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
- Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran
Keywords:
Transgeneration, opioid, cocaine, cannabis, nicotine, ethanol, parental.
Abstract: Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and
environmental factors are the two most important factors that make someone vulnerable to drug addiction.
Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational
inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal,
and biparental) drug exposure before conception changes the phenotype of the offspring, which is correlated
with neurochemical and neurostructural changes in the brain. The current paper reviews the effects
of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nicotine,
alcohol, and cannabis) before gestation in animal models.