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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Review Article

Epigenetic-related Effects of COVID-19 on Human Cells

Author(s): Arezoo Faramarzi, Reza Safaralizadeh*, Narges Dastmalchi and Shahram Teimourian

Volume 22, Issue 7, 2022

Published on: 17 June, 2022

Article ID: e200422203823 Pages: 6

DOI: 10.2174/1871526522666220420093029

Price: $65

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Abstract

Epigenetics is related to the various pathways that show long‐term impacts on the gene expression patterns without alterations in nucleotide sequences. Over the last decade, epigenetics advanced significantly in the science of biology, oncology, innate immunity as well as pathogens and infectious diseases. In the present paper, we aimed to review the relationships between COVID-19 and epigenetic alterations of the infected cells. Coronavirus is one of the known infectious diseases that causes respiratory infection, such as pneumonia and coughing, while in animals, it causes diarrhea and upper respiratory disorders. This virus could be transmitted human to human or human to an animal through droplets. It translocates via membrane ACE-2 exopeptidase into the host cells. In conclusion, hypomethylation of angiotensin II converting enzyme (ACE II) possibly upregulates its expression, enhancing the possibility of SARS-CoV-2 infection.

Keywords: SAR-CoV, ACE gene, epigenetic genes, methylation, histone modification, COVID-19, human cell.

Graphical Abstract

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