Title:Preclinical Studies on Neural Stem/Progenitor Cell Therapy for Ischemic
Stroke: A Systematic Review
Volume: 18
Issue: 3
Author(s): Mengze Zhang, Kan Wang, Chunran Xue, Chong Xie, Ze Wang, Yaying Song, Haojun Yu, Yong Hao*Yangtai Guan*
Affiliation:
- Department of Neurology, Renji Hospital, School of Medicine Shanghai Jiaotong University, 160 Pujian Rd, Shanghai 200127, P. R. China
- Department of Neurology, Renji Hospital, School of Medicine Shanghai Jiaotong University, 160 Pujian Rd, Shanghai 200127, P. R. China
Keywords:
Neural stem cells, transplantation, ischemic stroke, treatment outcome, animal experimentation, safety.
Abstract:
Background: Neural stem/progenitor cells (NSPCs) transplantation has been recognized in
recent years as an effective strategy for the treatment of ischemic stroke. Several preclinical studies have
demonstrated the feasibility, safety, and efficacy of NSPCs therapy.
Methods: We conducted a systematic review of the published literature in Pubmed reporting the use of
NSPCs in preclinical studies between 2010 and 2021. Based on the articles reporting data, the key factors
affecting efficacy were listed.
Results: A total of 71 preclinical studies, including 91 treatment arms, were identified. The results
showed that several factors could influence the outcomes of NSPCs transplantation, including the type of
donor cells, cell dose, time of administration after stroke, delivery route, and anesthetic. Treatment outcomes
were measured by infarct volume, behavioral tests, and molecular and cellular level results.
Conclusion: Most of the preclinical studies reported statistically significant effects and very few adverse
reactions. Transplantation of NSPCs for ischemic stroke still needs to be optimized for several key factors.
A standardized treatment outcome assessment could ease the translation of evidence in clinical settings.
