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Current Bioactive Compounds

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ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

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Mini-Review Article

Ramalin: A Multi-Mechanistic Lichen Metabolite of Pharmacological Importance

Author(s): Deepti Katiyar*, Priya Bansal, Abhishek Kumar and Surya Prakash

Volume 19, Issue 1, 2023

Published on: 19 August, 2022

Article ID: e240322202584 Pages: 7

DOI: 10.2174/1573407218666220324120229

Price: $65

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Abstract

Background: Ramalin (γ-glutamyl-N'-(2-hydroxyphenyl) hydrazide), a nitrogencontaining lichen secondary metabolite, was isolated from Ramalina terebrata, an Antarctic lichen. Since then, it has attracted several researchers, thus leading to various research investigations exploring the pharmacological potential of Ramalin.

Methods: The bibliographic databases were explored for the peer-reviewed research related to the pharmacological importance of Ramalin.

Results: The article summarizes the antioxidant, anti-cancer, anti-obesity, antibacterial, and antiallergic activities of this molecule. Additionally, the studies conducted to show the potential of Ramalin in atherosclerosis, atopic dermatitis, neurodegenerative disorders, hepatic fibrosis and its role in autophagy suppression and enzyme inhibition are also described briefly. Moreover, the experimental findings also depict that Ramalin did not show any toxicity.

Conclusion: The current review shall be beneficial for future researchers interested in working on Ramalin because it summarizes all the relevant publications starting from its first-time isolation to the articles of 2021.

Keywords: Lichen, Ramalina terebrata, ramalin, antioxidant, anti-cancer, anti-inflammatory.

Graphical Abstract

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