![conference banner](/images/conference-banner.jpeg)
摘要
免疫疗法继续重新定义实体瘤治疗领域,其中 PD-L1/PD-1 免疫检查点抑制剂具有最广泛的影响。作为全世界诊断出的最常见的癌症,人们对开发用于治疗早期和转移性乳腺癌的免疫疗法非常感兴趣。最近报道的几项临床试验结果已经确定了免疫治疗药物单独或与标准治疗联合治疗早期和转移性疾病的潜在作用。虽然迄今为止的试验很有希望,但免疫疗法仅被证明对选定的一组乳腺癌患者有益,这些患者由肿瘤亚型、PD-L1 表达和治疗线定义。随着超过 250 项试验的进行,新兴数据将使乳腺癌免疫治疗策略的进一步完善成为可能。整合多个推定的生物标志物并考虑早期反应或耐药性的动态标志物可能会为免疫治疗研究和整合到临床实践中的最佳患者选择提供信息。本综述将总结免疫检查点阻断 (ICB) 治疗早期和转移性乳腺癌的现有证据,重点介绍当前和未来潜在的治疗反应生物标志物。
关键词: 乳腺癌、免疫治疗、免疫检查点阻断、PD-L1、PD-1、三阴性乳腺癌、TNBC。
[http://dx.doi.org/10.1016/j.immuni.2019.08.004] [PMID: 31433971]
[http://dx.doi.org/10.1016/j.cell.2018.05.060] [PMID: 29961579]
[http://dx.doi.org/10.1200/JCO.2011.41.0902] [PMID: 23341518]
[http://dx.doi.org/10.1093/annonc/mdv241] [PMID: 26109735]
[http://dx.doi.org/10.1093/annonc/mdu112] [PMID: 24608200]
[http://dx.doi.org/10.3410/f.718509074.793498113]
[http://dx.doi.org/10.1093/annonc/mdy517] [PMID: 30475950]
[http://dx.doi.org/10.1093/annonc/mdy518] [PMID: 30475947]
[http://dx.doi.org/10.1016/S1470-2045(20)30754-3] [PMID: 33676601]
[http://dx.doi.org/10.1016/S1470-2045(21)00019-X] [PMID: 33676605]
[http://dx.doi.org/10.1186/s40425-019-0541-0] [PMID: 30867072]
[http://dx.doi.org/10.1016/j.annonc.2020.10.069]
[http://dx.doi.org/10.1016/j.annonc.2020.08.2243]
[http://dx.doi.org/10.1200/JCO.2020.38.15_suppl.1000]
[http://dx.doi.org/10.1056/NEJMoa1809615] [PMID: 30345906]
[http://dx.doi.org/10.1016/j.annonc.2021.08.2089]
[http://dx.doi.org/10.1016/j.annonc.2021.09.019] [PMID: 34678411]
[http://dx.doi.org/10.1158/1538-7445.SABCS16-P6-10-03]
[http://dx.doi.org/10.1001/jamaoncol.2018.4224] [PMID: 30242306]
[http://dx.doi.org/10.1038/s41568-019-0116-x] [PMID: 30755690]
[http://dx.doi.org/10.1038/nrclinonc.2016.66] [PMID: 27184417]
[http://dx.doi.org/10.1038/s41571-018-0142-8] [PMID: 30523282]
[http://dx.doi.org/10.1001/jamaoncol.2020.3524] [PMID: 32880602]
[http://dx.doi.org/10.1016/j.ejca.2021.02.028] [PMID: 33794440]
[http://dx.doi.org/10.1200/JCO.2020.38.15_suppl.1051]
[http://dx.doi.org/10.1038/s41467-021-24112-w] [PMID: 34172722]
[http://dx.doi.org/10.1371/journal.pone.0084927] [PMID: 24367702]
[http://dx.doi.org/10.1158/1078-0432.CCR-11-1142] [PMID: 21918170]
[http://dx.doi.org/10.1016/j.ccr.2010.06.014] [PMID: 20708157]
[http://dx.doi.org/10.1007/s10549-017-4537-5] [PMID: 29063313]
[http://dx.doi.org/10.1634/theoncologist.2019-0321] [PMID: 31420468]
[http://dx.doi.org/10.1016/S1470-2045(20)30465-4] [PMID: 33002436]
[http://dx.doi.org/10.1038/s41591-020-01189-2] [PMID: 33462450]
[http://dx.doi.org/10.1056/NEJMoa1809697] [PMID: 30280658]
[http://dx.doi.org/10.1016/S0140-6736(13)62422-8] [PMID: 24529560]
[http://dx.doi.org/10.1007/s10549-011-1895-2] [PMID: 22198468]
[http://dx.doi.org/10.1200/JCO.2011.39.2779] [PMID: 22649152]
[http://dx.doi.org/10.1200/JCO.1998.16.8.2672] [PMID: 9704717]
[http://dx.doi.org/10.1200/JCO.1997.15.7.2483] [PMID: 9215816]
[http://dx.doi.org/10.1016/S0140-6736(20)31953-X] [PMID: 32966830]
[http://dx.doi.org/10.1056/NEJMoa1910549] [PMID: 32101663]
[http://dx.doi.org/10.1158/1538-7445.SABCS19-GS3-04]
[http://dx.doi.org/10.1016/j.annonc.2021.06.014]
[http://dx.doi.org/10.1001/jamaoncol.2019.6650] [PMID: 32053137]
[http://dx.doi.org/10.1200/JCO.2019.37.15_suppl.TPS601]
[http://dx.doi.org/10.1200/JCO.2020.38.15_suppl.TPS604]
[http://dx.doi.org/10.1158/2326-6066.CIR-14-0133] [PMID: 25527356]
[http://dx.doi.org/10.1038/s41598-017-11905-7] [PMID: 28916815]
[http://dx.doi.org/10.1073/pnas.1016569108] [PMID: 21482773]
[http://dx.doi.org/10.1126/scitranslmed.aac4925] [PMID: 26606967]
[http://dx.doi.org/10.1016/j.annonc.2021.05.800]
[http://dx.doi.org/10.1016/S1470-2045(19)30689-8] [PMID: 31786121]
[http://dx.doi.org/10.1038/nature21349] [PMID: 28102259]
[http://dx.doi.org/10.1016/j.annonc.2021.02.006] [PMID: 33736924]
[http://dx.doi.org/10.1158/1538-7445.SABCS19-P3-09-05]
[http://dx.doi.org/10.1371/journal.pone.0115103] [PMID: 25501357]
[http://dx.doi.org/10.1093/annonc/mdx440.005]
[http://dx.doi.org/10.1016/j.ccell.2018.03.012] [PMID: 29634943]
[http://dx.doi.org/10.1093/jnci/djab004] [PMID: 33523233]
[http://dx.doi.org/10.1038/s41467-020-17537-2] [PMID: 32719340]
[http://dx.doi.org/10.1038/nrc.2017.74] [PMID: 28835723]
[http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.1006]
[http://dx.doi.org/10.1158/1538-7445.SABCS18-LB-225]
[http://dx.doi.org/10.1158/1538-7445.SABCS20-PD14-07]
[http://dx.doi.org/10.1038/s43018-020-0096-5]
[http://dx.doi.org/10.1038/s41467-020-14562-z] [PMID: 32075964]
[http://dx.doi.org/10.1016/S1470-2045(16)30406-5] [PMID: 27924752]
[http://dx.doi.org/10.1001/jamaoncol.2019.5241] [PMID: 31876896]
[http://dx.doi.org/10.1038/nri1937] [PMID: 16998510]
[http://dx.doi.org/10.1038/nrrheum.2016.209] [PMID: 28053336]
[http://dx.doi.org/10.1038/nri1350] [PMID: 15122202]
[http://dx.doi.org/10.1056/NEJMoa1606774] [PMID: 27718847]
[http://dx.doi.org/10.1200/JCO.2015.64.8931] [PMID: 27138582]
[http://dx.doi.org/10.1056/NEJMoa1910836] [PMID: 31562797]
[http://dx.doi.org/10.1056/NEJMoa1406498] [PMID: 25409260]
[http://dx.doi.org/10.1200/EDBK_240837] [PMID: 31099674]
[http://dx.doi.org/10.1158/2159-8290.CD-16-1223] [PMID: 27903500]
[http://dx.doi.org/10.1126/scitranslmed.aah3560] [PMID: 28251903]
[http://dx.doi.org/10.1007/s10549-021-06405-2] [PMID: 34623509]
![Wayfinder Image](/images/wayfinder.jpg)