Generic placeholder image

CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Editorial

The Current Evidence for the Therapeutic Role of Curcumin in Alzheimer’s Disease

Author(s): Abigail R. Bland, John C. Ashton, Mohammad Amjad Kamal and Amirhossein Sahebkar*

Volume 22, Issue 3, 2023

Published on: 07 March, 2022

Page: [318 - 320] Pages: 3

DOI: 10.2174/1871527321666220119105836

conference banner
Graphical Abstract
[1]
Erkkinen MG, Kim MO, Geschwind MD. Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. Cold Spring Harb Perspect Biol 2018; 10(4)
[2]
Du X, Wang X, Geng M. Alzheimer's disease hypothesis and related therapies. Transl Neurodegener 2018; 7: 2.
[3]
Abeysinghe A, Deshapriya R, Udawatte C. Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions. Life Sci 2020; 256: 117996.
[4]
Mendiola-Precoma J, Berumen LC, Padilla K, Garcia-Alcocer G. Therapies for Prevention and Treatment of Alzheimer's Disease. Biomed Res Int 2016; 2016: 2589276.
[5]
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature 2016; 537(7618): 50-6.
[6]
Shakeri A, Cicero AFG, Panahi Y, Mohajeri M, Sahebkar A. Curcumin: A naturally occurring autophagy modulator. J Cell Physiol 2019 May; 234(5): 5643-54. Epub 2018 Sep 21.
[http://dx.doi.org/10.1002/jcp.27404] [PMID: 30239005]
[7]
Afshari AR, Jalili-Nik M, Abbasinezhad-Moud F, et al. Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review. Curr Med Chem 2021; 28(39): 8116-38.
[http://dx.doi.org/10.2174/0929867327666201111145212] [PMID: 33176632]
[8]
Mortezaee K, Salehi E, Mirtavoos-Mahyari H, et al. Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy. J Cell Physiol 2019; 234(8): 12537-50.
[http://dx.doi.org/10.1002/jcp.28122] [PMID: 30623450]
[9]
Voulgaropoulou SD, van Amelsvoort T, Prickaerts J, Vingerhoets C. The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Res 2019; 1725: 146476.
[10]
Yang F, Lim GP, Begum AN, et al. Curcumin inhibits the formation of amyloid-beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 2005; 280(7): 5892-901.
[11]
Wang X, Kim JR, Lee SB, et al. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med 2014; 14: 88.
[12]
Parr C, Mirzaei N, Christian M, Sastre M. Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter. Faseb J 2015; 29(2): 623-35.
[13]
Awasthi H, Tota S, Hanif K, Nath C, Shukla R. Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow. Life Sci 2010; 86(3-4): 87-94.
[14]
Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol 2015; 29(5): 642-51.
[15]
Baum L, Lam CW, Cheung SK, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. J Clin Psychopharmacol 2008; 28(1): 110-3.
[16]
Small GW, Siddarth P, Li Z, et al. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry 2018; 26(3): 266-77.
[17]
Zhang L, Fiala M, Cashman J, et al. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis 2006; 10(1): 1-7.
[18]
Masoumi A, Goldenson B, Ghirmai S, et al. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers Dis 2009; 17(3): 703-17.

© 2024 Bentham Science Publishers | Privacy Policy