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Current Functional Foods

Editor-in-Chief

ISSN (Print): 2666-8629
ISSN (Online): 2666-8637

Review Article

Pharmacological and Nutritional Benefits of Flaxseed’s (Linum usitatissimum Linn.) Biocomponents

Author(s): Mohammad Tarique, Badruddeen*, Shahla Parveen, Farogh Ahsan, Mohammad Irfan Khan, Juber Akhtar, Mohammad Khalid, Gazanfer and Mohammad Muztaba

Volume 1, Issue 1, 2023

Published on: 06 January, 2022

Article ID: e060122200074 Pages: 13

DOI: 10.2174/2666862901666220106140913

Abstract

Linum usitatissimum (Linn.), commonly known as flaxseed, belongs to the family Linaceae. Flaxseed is a crop of blue flowers that produce small, flat seeds of golden yellow to reddish- brown color. It is a native of the Mediterranean and West Asia. Due to its health benefits associated with the high content of linolenic acid (ALA), flaxseed has played a major role in diet and research. The ALA is an essential omega-3-fatty acid, and also due to its presence a major lignan, i.e. secoisolariciresinol diglucoside (SDG). There is also a wide range of uses of flaxseed oil in skin health, anticoagulants, anticancer, ulcer treatment, muscle growth, and weight loss. The nutritional composition of flaxseed is about 30% carbohydrate, 18% protein, and 39% fat. Flaxseed contains most carbohydrates in the form of fiber and contains more than 45% omega-3 fatty acids. It also contains dietary fibers, proteins and polyunsaturated fatty acids. All the ingredients possess different health benefits. Although plant resources are the key ingredient in drug discovery, the popularity of flaxseed always fascinate scientists, the number of articles giving information about the chemical components of flaxseed and its potential clinical use is very little. This review provides a systematic summary of the research completed over the past decade and provides an up-to-date summary of the various bioactive and outlines the relationship between the nutritional and pharmacological use of flaxseed and its chemical ingredients.

Keywords: Flaxseed, lignan, fibers, Linum usitatissimum, nutrition, pharmacological use, chemical constituent.

Graphical Abstract
[1]
Boakye-Yiadom M, Kumadoh D, Adase E, Woode E. Medicinal plants with prospective benefits in the management of peptic ulcer diseases in Ghana. BioMed Res Int 2021; 2021: 5574041-9.
[http://dx.doi.org/10.1155/2021/5574041] [PMID: 34036100]
[2]
Ahsan F, Ansari TM, Usmani S, Bagga P. An insight on silk protein sericin: From processing to biomedical application. Drug Res (Stuttg) 2018; 68(6): 317-27.
[http://dx.doi.org/10.1055/s-0043-121464] [PMID: 29132177]
[3]
Noor G, Ahmad MA, Ahsan F, Mahmood T, Arif M, Khushtar M. A phytochemical and ethnopharmacological recapitulation on Hamelia patens. Drug Res (Stuttg) 2020; 70(5): 188-98.
[http://dx.doi.org/10.1055/a-1131-7856] [PMID: 32227313]
[4]
Ansari R, Zarshenas MM, Dadbakhsh AH. A review on pharmacological and clinical aspects of Linum usitatissimum L. Curr Drug Discov Technol 2019; 16(2): 148-58.
[http://dx.doi.org/10.2174/1570163815666180521101136] [PMID: 29779483]
[5]
Shim YY, Gui B, Arnison PG, Wang Y, Reaney MJT. Flaxseed (Linum usitatissimum L.) bioactive compounds and peptide nomenclature: A review. Trends Food Sci Technol 2014; 38: 5-20.
[http://dx.doi.org/10.1016/j.tifs.2014.03.011]
[6]
Adlercreutz H. Lignans and human health. Crit Rev Clin Lab Sci 2007; 44(5-6): 483-525.
[http://dx.doi.org/10.1080/10408360701612942] [PMID: 17943494]
[7]
Singh KK, Mridula D, Rehal J, Barnwal P. Flaxseed: A potential source of food, feed and fiber. Crit Rev Food Sci Nutr 2011; 51(3): 210-22.
[http://dx.doi.org/10.1080/10408390903537241] [PMID: 21390942]
[8]
Basch E, Bent S, Collins J, et al. Natural Standard Resource Collaboration. Flax and flaxseed oil (Linum usitatissimum): A review by the Natural Standard Research Collaboration. J Soc Integr Oncol 2007; 5(3): 92-105.
[http://dx.doi.org/10.2310/7200.2007.005] [PMID: 17761128]
[9]
Rhee Y, Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: A randomized crossover design. Nutr J 2011; 10: 44.
[http://dx.doi.org/10.1186/1475-2891-10-44] [PMID: 21554710]
[10]
Prasad K. Flaxseed and cardiovascular health. J Cardiovasc Pharmacol 2009; 54(5): 369-77.
[http://dx.doi.org/10.1097/FJC.0b013e3181af04e5] [PMID: 19568181]
[11]
Thakur G, Mitra A, Pal K, Rousseau D. Effect of flaxseed gum on reduction of blood glucose and cholesterol in type 2 diabetic patients. Int J Food Sci Nutr 2009; 60 (Suppl. 6): 126-36.
[http://dx.doi.org/10.1080/09637480903022735] [PMID: 19548163]
[12]
Hu C, Yuan YV, Kitts DD. Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro. Food Chem Toxicol 2007; 45(11): 2219-27.
[http://dx.doi.org/10.1016/j.fct.2007.05.017] [PMID: 17624649]
[13]
Kajla P, Sharma A, Sood DR. Flaxseed-a potential functional food source. J Food Sci Technol 2015; 52(4): 1857-71.
[http://dx.doi.org/10.1007/s13197-014-1293-y] [PMID: 25829567]
[14]
De Silva SF, Alcorn J. Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: Chemistry, pharmacokinetics, and molecular targets. Pharmaceuticals (Basel) 2019; 12(2): 76.
[http://dx.doi.org/10.3390/ph12020068] [PMID: 31060335]
[15]
Watanabe Y, Ohata K, Fukanoki A, et al. Antihypertensive and renoprotective effects of dietary flaxseed and its mechanism of action in deoxycorticosterone acetate-salt hypertensive rats. Pharmacology 2020; 105(1-2): 54-62.
[http://dx.doi.org/10.1159/000502789] [PMID: 31514180]
[16]
Salem MA, Ezzat SM, Giavalisco P, Sattar EA, El Tanbouly N. Application of a comprehensive metabolomics approach for the selection of flaxseed varieties with the highest nutritional and medicinal attributes. Yao Wu Shi Pin Fen Xi 2021; 29: 9.
[http://dx.doi.org/10.38212/2224-6614.3347]
[17]
Nemeth M, Eisenschenk I, Engelmann A, et al. Flaxseed oil as omega-3 polyunsaturated fatty acid source modulates cortisol concentrations and social dominance in male and female guinea pigs. Horm Behav 2021; 134: 105025-9.
[http://dx.doi.org/10.1016/j.yhbeh.2021.105025] [PMID: 34242874]
[18]
Kezimana P, Dmitriev AA, Kudryavtseva AV, Romanova EV, Melnikova NV. Secoisolariciresinol diglucoside of flaxseed and its metabolites: Biosynthesis and potential for nutraceuticals. Front Genet 2018; 9: 641-7.
[http://dx.doi.org/10.3389/fgene.2018.00641] [PMID: 30619466]
[19]
Yasmeen M, Nisar S, Tavallali V, Khalid T. A review of phytochemicals and uses of flaxseed. Int J Chem Biochem Sci 2018; 13: 75.
[20]
Hosseinian FS, Beta T. Patented techniques for the extraction and isolation of secoisolari-ciresinol diglucoside from flaxseed. Recent Pat Food Nutr Agric 2009; 1(1): 25-31.
[http://dx.doi.org/10.2174/2212798410901010025] [PMID: 20653523]
[21]
Carter J. Potential of flaxseed and flaxseed oil in baked goods and other products in human nutrition. Cereal Foods World 1993; 38: 753-9.
[22]
Rabetafika HN, Van Remoortel V, Danthine S, Paquot M, Blecker C. Flaxseed proteins: Food uses and health benefits. Int J Food Sci Technol 2011; 46: 221-8.
[http://dx.doi.org/10.1111/j.1365-2621.2010.02477.x]
[23]
Muir AD, Westcott ND. Quantitation of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal. J Agric Food Chem 2000; 48(9): 4048-52.
[http://dx.doi.org/10.1021/jf990922p] [PMID: 10995312]
[24]
Bakke J, Klosterman H. A new di glucoside from flaxseed. North Dakota Acad Sci 1956; 1: 18-22.
[25]
Chimichi S, Coran SA, Chimichi S, Bambagiotti-Alberti M, Giannellini V, Biddau B. Complete assignment of the 1h and 13c NMR spectra of secoisolariciresinol diglucoside, a mammalian lignan precursor isolated from linum usitatissimum complete assignment of the 1 h and 13 c nmr spectra of secoisolariciresinol diglucoside, a mammalian lignan precursor isolated from Linum usitatissimum. Magn Reson Chem 1999; 37: 860-3.
[http://dx.doi.org/10.1002/(SICI)1097-458X(199911)37:11<860::AID-MRC559>3.0.CO;2-A]
[26]
Qiu S-X, Lu Z-Z, Luyengi L, et al. Isolation and characterization of flaxseed (Linum usitatissimum) constituents. Pharm Biol 1999; 37: 1-7.
[http://dx.doi.org/10.1076/phbi.37.1.1.6320]
[27]
Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N. Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer 2006; 54(2): 184-201.
[http://dx.doi.org/10.1207/s15327914nc5402_5] [PMID: 16898863]
[28]
Kamal-Eldin A, Peerlkamp N, Johnsson P, et al. An oligomer from flaxseed composed of secoisolariciresinoldiglucoside and 3-hydroxy-3-methyl glutaric acid residues. Phytochemistry 2001; 58(4): 587-90.
[http://dx.doi.org/10.1016/S0031-9422(01)00279-5] [PMID: 11576603]
[29]
Bambagiotti-Alberti M, Coron SA, Ghiara C, Moreti G, Raffaelli A, Traldi P. Investigation of mammalian lignan precursors in flax seed: first evidence of secoisolariciresinol diglucoside in two isomeric forms by liquid chromatograph/mass spectrometry. Rapid Commun Mass Spectrom 1994; 8(12): 929-32.
[http://dx.doi.org/10.1002/rcm.1290081204] [PMID: 7696701]
[30]
Eliasson C, Kamal-Eldin A, Andersson R, Åman P. High-performance liquid chromatographic analysis of secoisolariciresinol diglucoside and hydroxycinnamic acid glucosides in flaxseed by alkaline extraction. J Chromatogr A 2003; 1012(2): 151-9.
[http://dx.doi.org/10.1016/S0021-9673(03)01136-1] [PMID: 14521311]
[31]
Sicilia T, Niemeyer HB, Honig DM, Metzler M. Identification and stereochemical characterization of lignans in flaxseed and pumpkin seeds. J Agric Food Chem 2003; 51(5): 1181-8.
[http://dx.doi.org/10.1021/jf0207979] [PMID: 12590454]
[32]
Meagher LP, Beecher GR, Flanagan VP, Li BW. Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal. J Agric Food Chem 1999; 47(8): 3173-80.
[http://dx.doi.org/10.1021/jf981359y] [PMID: 10552626]
[33]
Mazur WM, Uehara M, Wähälä K, Adlercreutz H. Phyto-oestrogen content of berries, and plasma concentrations and urinary excretion of enterolactone after a single strawberry-meal in human subjects. Br J Nutr 2000; 83(4): 381-7.
[PMID: 10858696]
[34]
Bartkiene E, Skabeikyte E, Krungleviciute V, et al. The influence of fermentation on the content of alkylresorcinols and lignans in plant products. Open Biotechnol J 2015; 9: 31-8.
[http://dx.doi.org/10.2174/1874070701509010031]
[35]
Touré A, Xueming X. Flaxseed lignans: source, biosynthesis, metabolism, antioxidant activity, bio-active components, and health benefits. Compr Rev Food Sci Food Saf 2010; 9(3): 261-9.
[http://dx.doi.org/10.1111/j.1541-4337.2009.00105.x] [PMID: 33467817]
[36]
Fukumitsu S, Aida K, Shimizu H, Toyoda K. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. Nutr Res 2010; 30(7): 441-6.
[http://dx.doi.org/10.1016/j.nutres.2010.06.004] [PMID: 20797475]
[37]
Prasad K. Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. Mol Cell Biochem 1997; 168(1-2): 117-23.
[http://dx.doi.org/10.1023/A:1006847310741] [PMID: 9062900]
[38]
Prasad K. Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone. Int J Angiol 2000; 9(4): 220-5.
[http://dx.doi.org/10.1007/BF01623898] [PMID: 11062311]
[39]
Adolphe JL, Whiting SJ, Juurlink BHJ, Thorpe LU, Alcorn J. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Br J Nutr 2010; 103(7): 929-38.
[http://dx.doi.org/10.1017/S0007114509992753] [PMID: 20003621]
[40]
Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis 1996; 17(6): 1373-6.
[http://dx.doi.org/10.1093/carcin/17.6.1373] [PMID: 8681458]
[41]
Sok D-E, Cui HS, Kim MR. Isolation and bioactivities of furfuran type lignan compounds from edible plants. Recent Pat Food Nutr Agric 2009; 1(1): 87-95.
[http://dx.doi.org/10.2174/2212798410901010087] [PMID: 20653530]
[42]
Westcott N, Muir A. Chemical Studies on the Constituents of Linum Spp Flax the genus Linum. New York: Taylor and Francis 2003; pp. 55-73.
[43]
Schweigerer L, Christeleit K, Fleischmann G, et al. Identification in human urine of a natural growth inhibitor for cells derived from solid paediatric tumours. Eur J Clin Invest 1992; 22(4): 260-4.
[http://dx.doi.org/10.1111/j.1365-2362.1992.tb01460.x] [PMID: 1499641]
[44]
Sturgeon SR, Heersink JL, Volpe SL, et al. Effect of dietary flaxseed on serum levels of estrogens and androgens in postmenopausal women. Nutr Cancer 2008; 60(5): 612-8.
[http://dx.doi.org/10.1080/01635580801971864] [PMID: 18791924]
[45]
Adlercreutz H, Bannwart C, Wähälä K, et al. Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol 1993; 44(2): 147-53.
[http://dx.doi.org/10.1016/0960-0760(93)90022-O] [PMID: 8382517]
[46]
Wang C, Mäkelä T, Hase T, Adlercreutz H, Kurzer MS. Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. J Steroid Biochem Mol Biol 1994; 50(3-4): 205-12.
[http://dx.doi.org/10.1016/0960-0760(94)90030-2] [PMID: 8049151]
[47]
Hutchins A, Slavin J. Effects of flaxseed on sex hormone metabolism. Flaxseed Hum Nutr 2003; 8: 126-49.
[http://dx.doi.org/10.1201/9781439831915.ch6]
[48]
Singh K, Jhamb S, Kumar R. Effect of pretreatments on performance of screw pressing for flaxseed. J Food Process Eng 2012; 35: 543-56.
[http://dx.doi.org/10.1111/j.1745-4530.2010.00606.x]
[49]
Edel AL, Aliani M, Pierce GN. Stability of bioactives in flaxseed and flaxseed-fortified foods. Food Res Int 2015; 77: 140-55.
[http://dx.doi.org/10.1016/j.foodres.2015.07.035]
[50]
Oomah BD, Mazza G. Flaxseed proteins-A review. Food Chem 1993; 48: 109-14.
[http://dx.doi.org/10.1016/0308-8146(93)90043-F]
[51]
Mazza G, Biliaderis C. Functional properties of flax seed mucilage. J Food Sci 1989; 54: 1302-5.
[http://dx.doi.org/10.1111/j.1365-2621.1989.tb05978.x]
[52]
Kaewmanee T, Bagnasco L, Benjakul S, et al. Characterisation of mucilages extracted from seven Italian cultivars of flax. Food Chem 2014; 148: 60-9.
[http://dx.doi.org/10.1016/j.foodchem.2013.10.022] [PMID: 24262527]
[53]
Qian KY, Cui SW, Wu Y, Goff HD. Flaxseed gum from flaxseed hulls: Extraction, fractionation, and characterization. Food Hydrocoll 2012; 28: 275-83.
[http://dx.doi.org/10.1016/j.foodhyd.2011.12.019]
[54]
Cui W, Mazza G, Biliaderis CG. Chemical structure, molecular size distributions, and rheological properties of flaxseed gum. J Agric Food Chem 1994; 42: 1891-5.
[http://dx.doi.org/10.1021/jf00045a012]
[55]
Rebolé A, Rodríguez ML, Ortiz LT, Alzueta C, Centeno C, Treviño J. Mucilage in Linseed: Effects on the intestinal viscosity and nutrient digestion in broiler chicks. J Sci Food Agric 2002; 82: 1171-6.
[http://dx.doi.org/10.1002/jsfa.1164]
[56]
Whelton SP, Hyre AD, Pedersen B, Yi Y, Whelton PK, He J. Effect of dietary fiber intake on blood pressure: A meta-analysis of randomized, controlled clinical trials. J Hypertens 2005; 23(3): 475-81.
[http://dx.doi.org/10.1097/01.hjh.0000160199.51158.cf] [PMID: 15716684]
[57]
Kapoor S, Sachdeva R, Kochhar A. Flaxseed: A potential treatment of lowering blood glucose and lipid profile among diabetic females. Indian J Nutr Diet 2011; 48: 529-36.
[58]
Ferrannini E, Buzzigoli G, Bonadonna R, et al. Insulin resistance in essential hypertension. N Engl J Med 1987; 317(6): 350-7.
[http://dx.doi.org/10.1056/NEJM198708063170605] [PMID: 3299096]
[59]
Reaven GM. Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease. J Clin Endocrinol Metab 2003; 88(6): 2399-403.
[http://dx.doi.org/10.1210/jc.2003-030087] [PMID: 12788834]
[60]
Fodje AML, Chang PR, Leterme P. In vitro bile acid binding and short-chain fatty acid profile of flax fiber and ethanol co-products. J Med Food 2009; 12(5): 1065-73.
[http://dx.doi.org/10.1089/jmf.2008.0242] [PMID: 19857071]
[61]
Theuwissen E, Mensink RP. Water-soluble dietary fibers and cardiovascular disease. Physiol Behav 2008; 94(2): 285-92.
[http://dx.doi.org/10.1016/j.physbeh.2008.01.001] [PMID: 18302966]
[62]
Ye Z, Arumugam V, Haugabrooks E, Williamson P, Hendrich S. Soluble dietary fiber (Fibersol-2) decreased hunger and increased satiety hormones in humans when ingested with a meal. Nutr Res 2015; 35(5): 393-400.
[http://dx.doi.org/10.1016/j.nutres.2015.03.004] [PMID: 25823991]
[63]
Lin HV, Frassetto A, Kowalik EJ Jr, et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 2012; 7(4): e35240.
[http://dx.doi.org/10.1371/journal.pone.0035240] [PMID: 22506074]
[64]
Remely M, Aumueller E, Merold C, et al. Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. Gene 2014; 537(1): 85-92.
[http://dx.doi.org/10.1016/j.gene.2013.11.081] [PMID: 24325907]
[65]
Du H, van der A DL, Boshuizen HC, et al. Dietary fiber and subsequent changes in body weight and waist circumference in European men and women. Am J Clin Nutr 2010; 91(2): 329-36.
[http://dx.doi.org/10.3945/ajcn.2009.28191] [PMID: 20016015]
[66]
Burr GO, Burr MM. On the nature and role of the fatty acids essential in nutrition. J Biol Chem 1930; 86: 587-621.
[http://dx.doi.org/10.1016/S0021-9258(20)78929-5]
[67]
De Lorgeril M, Salen P, Laporte F, De Leiris J. Alpha-linolenic acid in the prevention and treatment of coronary heart disease. Eur Heart J Suppl 2001; 3: 26-32.
[http://dx.doi.org/10.1016/S1520-765X(01)90115-4]
[68]
Hurteau M-C. Unique new food products contain good omega fats. J Food Sci Educ 2006; 3: 52-3.
[http://dx.doi.org/10.1111/j.1541-4329.2004.tb00044.x]
[69]
Arend WP, Dayer J-M. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum 1995; 38(2): 151-60.
[http://dx.doi.org/10.1002/art.1780380202] [PMID: 7848304]
[70]
Kremer JM. n-3 fatty acid supplements in rheumatoid arthritis. Am J Clin Nutr 2000; 71(1) (Suppl.): 349S-51S.
[http://dx.doi.org/10.1093/ajcn/71.1.349s] [PMID: 10617995]
[71]
Orcheson LJ, Rickard SE, Seidl MM, Thompson LU. Flaxseed and its mammalian lignan precursor cause a lengthening or cessation of estrous cycling in rats. Cancer Lett 1998; 125(1-2): 69-76.
[http://dx.doi.org/10.1016/S0304-3835(97)00482-5] [PMID: 9566698]
[72]
Gonzalez MJ, Schemmel RA, Gray JI, Dugan L Jr, Sheffield LG, Welsch CW. Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic nude mice: relationship between carcinoma growth and lipid peroxidation product levels. Carcinogenesis 1991; 12(7): 1231-5.
[http://dx.doi.org/10.1093/carcin/12.7.1231] [PMID: 2070488]
[73]
Gabor H, Abraham S. Effect of dietary menhaden oil on tumor cell loss and the accumulation of mass of a transplantable mammary adenocarcinoma in BALB/c mice. J Natl Cancer Inst 1986; 76(6): 1223-9.
[PMID: 3458958]
[74]
Ridges L, Sunderland R, Moerman K, Meyer B, Astheimer L, Howe P. Cholesterol lowering benefits of soy and linseed enriched foods. Asia Pac J Clin Nutr 2001; 10(3): 204-11.
[http://dx.doi.org/10.1046/j.1440-6047.2001.00253.x] [PMID: 11708310]
[75]
Bhathena SJ, Ali AA, Haudenschild C, et al. Dietary flaxseed meal is more protective than soy protein concentrate against hypertriglyceridemia and steatosis of the liver in an animal model of obesity. J Am Coll Nutr 2003; 22(2): 157-64.
[http://dx.doi.org/10.1080/07315724.2003.10719289] [PMID: 12672712]
[76]
Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MMB. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study. Am J Clin Nutr 2003; 78(1): 40-6.
[http://dx.doi.org/10.1093/ajcn/78.1.40] [PMID: 12816769]
[77]
Locke C, Stoll A. Omega-3 Fatty Acids in Major Depression.Nutrition and Fitness: Diet, Genes, Physical Activity and Health.Basel: Karger. 2001; Vol. 89: pp. 173-85.
[http://dx.doi.org/10.1159/000059784]
[78]
Madhusudhan KT, Singh N. Isolation and characterization of the major fraction (12 S) of linseed proteins. J Agric Food Chem 1985; 33: 673-7.
[http://dx.doi.org/10.1021/jf00064a026]
[79]
Chung MWY, Lei B, Li-Chan ECY. Isolation and structural characterization of the major protein fraction from norman flaxseed (Linum usitatissimum L.). Food Chem 2005; 90: 271-9.
[http://dx.doi.org/10.1016/j.foodchem.2003.07.038]
[80]
Oomah BD. Flaxseed as a functional food source. J Sci Food Agric 2001; 81: 889-94.
[http://dx.doi.org/10.1002/jsfa.898]
[81]
Bhathena SJ, Ali AA, Mohamed AI, Hansen CT, Velasquez MT. Differential effects of dietary flaxseed protein and soy protein on plasma triglyceride and uric acid levels in animal models. J Nutr Biochem 2002; 13(11): 684-9.
[http://dx.doi.org/10.1016/S0955-2863(02)00227-9] [PMID: 12550066]
[82]
Xu Y, Hall C III, Wolf-Hall C. Antifungal activity stability of flaxseed protein extract using response surface methodology. J Food Sci 2008; 73(1): M9-M14.
[http://dx.doi.org/10.1111/j.1750-3841.2007.00576.x] [PMID: 18211360]
[83]
Kapoor L. Handbook of Ayurvedic Medicinal Plants. London: CRC Press 2005.
[84]
Bernacchia R, Preti R, Vinci G. Chemical composition and health benefits of flaxseed. Austin J Nutr Food Sci 2014; 2: 1045-51.
[85]
Winter R. Vitamin E: Your protection against exercise fatigue, weakened immunity, heart disease, cancer, aging, diabetic damage, environmental toxins. New York: Three Rivers Press 2013.
[86]
Meagher EA, Barry OP, Lawson JA, Rokach J, FitzGerald GA. Effects of vitamin E on lipid peroxidation in healthy persons. JAMA 2001; 285(9): 1178-82.
[http://dx.doi.org/10.1001/jama.285.9.1178] [PMID: 11231747]
[87]
Goyal A, Sharma V, Upadhyay N, Gill S, Sihag M. Flax and flaxseed oil: an ancient medicine & modern functional food. J Food Sci Technol 2014; 51(9): 1633-53.
[http://dx.doi.org/10.1007/s13197-013-1247-9] [PMID: 25190822]
[88]
Thompson LU, Cunnane SC. Flaxseed in Human Nutrition. (2nd ed.), New York: AOCS Publishing 2003.
[http://dx.doi.org/10.1201/9781003040378]
[89]
Joshi K, Lad S, Kale M, et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids 2006; 74(1): 17-21.
[http://dx.doi.org/10.1016/j.plefa.2005.10.001] [PMID: 16314082]
[90]
Coulman KD, Liu Z, Michaelides J, Quan Hum W, Thompson LU. Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women. Mol Nutr Food Res 2009; 53(11): 1366-75.
[http://dx.doi.org/10.1002/mnfr.200900032] [PMID: 19824016]
[91]
Khalesi S, Irwin C, Schubert M. Flaxseed consumption may reduce blood pressure: a systematic review and meta-analysis of controlled trials. J Nutr 2015; 145(4): 758-65.
[http://dx.doi.org/10.3945/jn.114.205302] [PMID: 25740909]
[92]
McKie R, LoVecchio F. Complications of supplements and herbal medications. Prim Care Reports 2013; 19: 145-54.
[93]
Wanasundara P, Shahidi F. Removal of flaxseed mucilage by chemical and enzymatic treatments. Food Chem 1997; 59: 47-55.
[http://dx.doi.org/10.1016/S0308-8146(96)00093-3]
[94]
Kaithwas G, Mukherjee A, Chaurasia AK, Majumdar DK. Anti-inflammatory, analgesic and antipyretic activities of Linum usitatissimum L. (flaxseed/linseed) fixed oil. Indian J Exp Biol 2011; 49(12): 932-8.
[PMID: 22403867]
[95]
Demark-Wahnefried W, Price DT, Polascik TJ, et al. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 2001; 58(1): 47-52.
[http://dx.doi.org/10.1016/S0090-4295(01)01014-7] [PMID: 11445478]
[96]
Chen J, Saggar JK, Corey P, Thompson LU. Flaxseed cotyledon fraction reduces tumour growth and sensitises tamoxifen treatment of human breast cancer xenograft (MCF-7) in athymic mice. Br J Nutr 2011; 105(3): 339-47.
[http://dx.doi.org/10.1017/S0007114510003557] [PMID: 21138602]
[97]
Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett 1991; 60(2): 135-42.
[http://dx.doi.org/10.1016/0304-3835(91)90220-C] [PMID: 1657368]
[98]
Rath BP, Pradhan D. Antidepressant activity of linum usitatissimum extract. Int J Pharmacogn Phytochem Res 2012; 1: 29-32.
[99]
Ghule AE, Jadhav SS, Bodhankar SL. Effect of ethanolic extract of seeds of Linum usitatissimum (Linn.) in hyperglycaemia associated ros production in pbmncs and pancreatic tissue of alloxan induced diabetic rats. Asian Pac J Trop Dis 2012; 2: 405-10.
[http://dx.doi.org/10.1016/S2222-1808(12)60088-7]
[100]
Amin T, Thakur M. A comparative study on proximate composition, phytochemical screening, antioxidant and antimicrobial activities of Linum usitatisimum L. (Flaxseeds). Int J Curr Microbiol Appl Sci 2014; 3: 465-81.
[101]
Zanwar A, Hegde M, Bodhankar S. In vitro antioxidant activity of ethanolic extract of Linum usitatissimum. Pharmacol 2010; 1: 683-96.
[102]
Dugani A, Auzzi A, Naas F, Megwez S. Effects of the oil and mucilage from flaxseed (Linum usitatissimum) on gastric lesions induced by ethanol in rats. Libyan J Med 2008; 3(4): 166-9.
[http://dx.doi.org/10.3402/ljm.v3i4.4787] [PMID: 21503150]
[103]
Hanif Palla A, Gilani AH. Dual effectiveness of Flaxseed in constipation and diarrhea: Possible mechanism. J Ethnopharmacol 2015; 169: 60-8.
[http://dx.doi.org/10.1016/j.jep.2015.03.064] [PMID: 25889554]
[104]
Ward WE, Yuan YV, Cheung AM, Thompson LU. Exposure to purified lignan from flaxseed (Linum usitatissimum) alters bone development in female rats. Br J Nutr 2001; 86(4): 499-505.
[http://dx.doi.org/10.1079/BJN2001429] [PMID: 11591237]
[105]
Beroual K, Halmi S, Maameri Z, et al. Pharmacological aspect of Linum usitatissimum: Flax ingestion on hair growth in rabbits. J Nat Prod Plant Resour 2014; 4: 4-7.
[106]
Prasad K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 1999; 99(10): 1355-62.
[http://dx.doi.org/10.1161/01.CIR.99.10.1355] [PMID: 10077521]
[107]
Fernandes FS, de Souza AS. do Carmo Md, Boaventura GT. Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: implications for growth, locomotor activity and spatial memory. Nutrition 2011; 27(10): 1040-7.
[http://dx.doi.org/10.1016/j.nut.2010.11.001] [PMID: 21439792]
[108]
Avelino APA, Oliveira GMM, Ferreira CCD, Luiz RR, Rosa G. Additive effect of linseed oil supplementation on the lipid profiles of older adults. Clin Interv Aging 2015; 10: 1679-85.
[PMID: 26543357]

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