Abstract
Chloro-s-triazines-atrazine, cyanazine, propazine, simazine, and terbuthylazine-are structurally similar herbicides, differing only in specific s-triazine4-and 6-N alkyl substituents. It is generally regarded that their toxicokinetics, such as, metabolic pathways, biological effects and toxicities, also share more similar features than the differences. Consequently, it is useful to compare their characteristics to potentially find useful structure-activity relationships or other similarities or differences regarding different active compounds, their metabolites, and biological effects including toxic outcomes. The ultimate goal of these exercises is to apply the summarized knowledge-as far as it is possible regarding a patchy and often inadequate database-to cross the in vitro-in vivo and animal-human borders and integrate the available data to enhance toxicological risk assessment for the benefit of humans and ecosystems.
Keywords: Chloro-s-triazines, biotransformation, metabolites, toxicity, human exposure, regulatory guidance.
Erratum In:
Chloro-s-triazenes-toxicokinetic, Toxicodynamic, Human
Exposure, and Regulatory Considerations
Current Drug Metabolism
Title:Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations
Volume: 22 Issue: 8
Author(s): Khaled Abass*, Olavi Pelkonen and Arja Rautio
Affiliation:
- Arctic Health, Faculty of Medicine, University of Oulu, Oulu, P.O. Box 7300, FI-90014,Finland
Keywords: Chloro-s-triazines, biotransformation, metabolites, toxicity, human exposure, regulatory guidance.
Abstract: Chloro-s-triazines-atrazine, cyanazine, propazine, simazine, and terbuthylazine-are structurally similar herbicides, differing only in specific s-triazine4-and 6-N alkyl substituents. It is generally regarded that their toxicokinetics, such as, metabolic pathways, biological effects and toxicities, also share more similar features than the differences. Consequently, it is useful to compare their characteristics to potentially find useful structure-activity relationships or other similarities or differences regarding different active compounds, their metabolites, and biological effects including toxic outcomes. The ultimate goal of these exercises is to apply the summarized knowledge-as far as it is possible regarding a patchy and often inadequate database-to cross the in vitro-in vivo and animal-human borders and integrate the available data to enhance toxicological risk assessment for the benefit of humans and ecosystems.
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Cite this article as:
Abass Khaled *, Pelkonen Olavi and Rautio Arja , Chloro-s-triazines-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations, Current Drug Metabolism 2021; 22 (8) . https://dx.doi.org/10.2174/1389200222666210701164945
DOI https://dx.doi.org/10.2174/1389200222666210701164945 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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