Title:One-Pot Glycosylation Strategy for Rapid Access of Oligosaccharides with Wide Range of Molecular Diversity
Volume: 25
Issue: 20
Author(s): Rekha Sangwan and Pintu Kumar Mandala*
Affiliation:
- Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, P.O. Box 173, Lucknow, 226 031,India
Keywords:
Glycosylation, one-pot, carbohydrate, oligosaccharide, orthogonal, preactivation.
Abstract: In carbohydrate chemistry, the synthesis of complex saccharides with well-defined
structures is the most formidable process as it is quite strenuous to isolate carbohydrates in
acceptable purity and amounts from natural sources. Therefore, complex saccharides with
well-defined structures are often most conveniently accessed through chemical syntheses.
This review mainly focuses on the methodologies for one-pot glycosylation into the complex
glycans from the non-reducing end to reducing end and vice versa, orthogonal, preactivation
based, photochemical as well as hybrid one-pot glycosylation. The main goal of this review in
the carbohydrate community was to rapidly synthesize biologically relevant glycans that can
be implemented for research in carbohydrate-based vaccine development, diagnostics, as well
as drug discovery.