Title:The Clinical Relevance of Differential Cell Counts in Induced Sputum and its Relationship with Various forms of Asthma
Volume: 17
Issue: 2
Author(s): Vasilii Chulkov*, Minina Elena, Larisa Medvedeva, Roman Testov and Alexei Shestakov
Affiliation:
- Department of Faculty Therapy, South Ural State Medical University, Chelyabinsk Oblast, 454092,Russian Federation
Keywords:
Asthma, bronchial mucosa, sputum, periostin, anaphylatoxin C3a, respiratory tract infections.
Abstract: The article provides an overview of modern concepts of induced sputum analysis and a
description of the methodology and protocols for the collection of induced sputum in adults and
children. This paper describes the cellular composition of induced sputum in healthy people and in
patients with asthma in detail, analyses the significance of the sputum eosinophil count as a prognostic
and diagnostic criterion and the role of other cells, such as neutrophils, macrophages, basophils.
In this article, we review a number of asthma biomarkers of inflammation and remodeling
of the airways in asthma, which can be determined in sputum (anaphylatoxin C3a, clusterin, periostin).
In addition, we summarize recent data about asthma phenotypes and describe the possibilities
of using induced sputum analysis as a diagnostic and therapeutic tool for personalized anti-inflammatory
therapy for asthma.