Title:Therapeutic Potential of Natural Compounds in Lung Cancer
Volume: 28
Issue: 39
Author(s): Minnatallah Al-Yozbaki, Peter J. Wilkin, Girish Kumar Gupta and Cornelia M. Wilson*
Affiliation:
- Canterbury Christ Church University, School of Human and Life Sciences, Life Sciences Industry Liaison Lab, Sandwich,United Kingdom
Keywords:
Lung cancer, natural compounds, apoptosis, therapy, drug-drug interactions, cell signalling pathways.
Abstract: Lung cancer is a leading cause of cancer deaths worldwide. The management
of lung cancer treatment is often ineffective as a result of the development of drug resistance,
reactions to treatment, drug-drug interactions or non-specific targeting of the anticancer
drugs. Natural compounds show promise and potential activity in lung cancer
with very few side effects. While, the combinatorial action of an anti-cancer drug with a
natural compound provides synergistic action which helps boost the overall therapeutic
action against cancer cells. In cancer, there is a dysregulation of apoptosis which facilitates
the cancer cell to survive, resulting in progression of cancer. Many cancer drugs
cause mutations of genes that regulate cancer and should kill the cancer cell but lead to
chemoresistance. There are many natural compounds that could specifically target different
cell signalling pathways associated with cancer progression to provide a cytotoxic effect
in the target cell. The importance of these compounds is emerging in many therapies
developed with dual action often including a natural compound. In this review, we present
a selection of these natural compounds and how they target lung cancer cells with a
focus on the cell signalling pathways. Further work is required to delineate the potential
action of natural compounds in the treatment against cancer.
