Title:Polymers Based on Phenyl Boric Acid in Tumor-Targeted Therapy
Volume: 21
Issue: 17
Author(s): Dexia Luo, Zheng Yao* Junzi Wu*
Affiliation:
- School of Basic Medical, Yunnan University of Chinese Medicine, Kunming Yunnan, 650500,China
- School of Basic Medical, Yunnan University of Chinese Medicine, Kunming Yunnan, 650500,China
Keywords:
Phenyl boric acid, research progress, tumor-targeted therapy, sialic acid, ATP, nano-polymers.
Abstract:
Background: Tumors are still among the major challenges to human health. Tumor-targeted therapy
is an effective way to treat tumors based on precise medical models. Sialic acid (SA) is overexpressed on the
surface of tumor cells, and Phenyl Boric Acid (PBA) can specifically bind to SA. However, studies on the use
of PBA in tumor-targeted therapy are few.
Objective: To summarize and analyze the characteristics and influencing factors of tumor targeted therapy in recent
years, and the influencing factors of phenyl boric acid modified polymers in tumor targeted therapy, such
as hydrogen ion concentration (pH), Adenosine Triphosphate (ATP), and sugars. This paper describes the application
of phenyl boric acid partially functionalized nano-polymers in various types of targeted tumors, such as
breast cancer, lung adenocarcinoma, liver cancer, and so forth. In order to further improve the basic research
and clinical workers' understanding of nano-preparations and tumor targeted therapy. At the same time, it is also
expected to promote the development value of phenyl boric acid.
Methods: The findings on tumor-targeted therapy and the role of partially functionalized polymers with PBA in
different tumors at home and abroad has been analyzed and summarized in recent years.
Results: Tumor-targeted therapy is a promising treatment for tumors. PBA promotes the treatment of tumors using
SA, which is highly expressed on the surface of tumor cells.
Conclusion: Tumor-targeted therapy has shown great prospects for clinical application in recent years. PBA is
beneficial as a member of the drug loading system. Further studies are still needed to promote its development
and application.
