摘要
背景:OX40 (CD134) 及其结合伴侣 OX40L (CD252) 在活化的 CD4、CD8 T 细胞以及其他几种淋巴和非淋巴细胞上表达。 OX40L 属于 TNF 家族成员,一种 34 kDa 的 II 型跨膜蛋白。人 OX40 和 OX40L 的结晶复合物是一个 OX40L(三聚体)和三个 OX40 单体的三聚体结构。 OX40 和 OX40L 调节 T 细胞、抗原呈递细胞和自然杀伤 (NK) 细胞的细胞因子产生,并调节细胞因子受体信号。 方法:在本综述中,提供了 OX40/OX40L 结构特征及其与癌症相互作用的最新概述。 结果:最近的研究表明,OX40 的刺激对于癌症的治疗性免疫策略是有用的。 OX40 作为次级共刺激免疫检查点分子; OX40 与其配体的结合增强了 CD4+ 和 CD8+ T 细胞的增强、存活、记忆形成、效应功能和回忆反应。 结论:本综述强调 OX40-OX40L 相互作用在 CD4+ 和 CD8+ T 细胞中都起着至关重要的作用。通过OX40的信号可以消除Tregs的抑制活性,阻止效应T细胞对Tregs的诱导,降低Foxp3的表达,并诱导记忆和效应T淋巴细胞的增殖。此外,当转移到荷瘤受体时,它们产生增殖能力并成功消除已建立的肿瘤。
关键词: OX40、OX40 配体、癌症、金属蛋白酶、自然杀伤细胞、T 细胞。
Current Medicinal Chemistry
Title:OX40 and OX40L Interaction in Cancer
Volume: 28 Issue: 28
关键词: OX40、OX40 配体、癌症、金属蛋白酶、自然杀伤细胞、T 细胞。
摘要:
Background: OX40 (CD134) and its binding partner, OX40L (CD252), are expressed on activated CD4, CD8 T-cells, and several other lymphoid and non-lymphoid cells. OX40L belongs to a TNF family member, a 34 kDa type II transmembrane protein. The crystallized complex of human OX40 and OX40L is a trimeric contableuration of one OX40L (trimer) and three OX40 monomers. OX40 and OX40L regulate cytokine production from T-cells, antigen-presenting cells, and natural killer (NK) cells, and modulate cytokine receptor signaling.
Methods: In this review, an updated overview of the structural features of OX40/OX40L and their interactions with cancer are provided.
Results: Recent studies have shown that stimulation of OX40 is useful for therapeutic immunization strategies for cancer. OX40 serves as a secondary costimulatory immune checkpoint molecule; the binding of OX40 to its ligand enhances the augmentation, survival, memory formation, effector function, and recall responses of both CD4+ and CD8+ T-cells.
Conclusion: This review highlights that OX40-OX40L interactions play crucial roles in both CD4+ and CD8+ T-cells. Signals through OX40 can abolish the suppressive activity of Tregs, prevent the induction of Tregs from effector T-cells, reduce Foxp3 expression, and induce the proliferation of memory and effector T lymphocytes. Additionally, when transferred into tumor-bearing recipients, they generate proliferation capability and successfully eliminate the established tumor.
Export Options
About this article
Cite this article as:
OX40 and OX40L Interaction in Cancer, Current Medicinal Chemistry 2021; 28 (28) . https://dx.doi.org/10.2174/0929867328666201229123151
DOI https://dx.doi.org/10.2174/0929867328666201229123151 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Review on Documented Medicinal Plants used for the Treatment of
Cancer
Current Traditional Medicine Elucidation of Abnormal Extracellular Regulated Kinase (ERK) Signaling and Associations with Syndromic and Non-syndromic Autism
Current Drug Targets Marine Natural Products as a Promising Source of Therapeutic Compounds to Target Cancer Stem Cells
Current Medicinal Chemistry Melanocortin Receptor Type 3 as a Potential Target for Anti-Inflammatory Therapy
Current Drug Targets - Inflammation & Allergy Statins and the Brain: More than Lipid Lowering Agents?
Current Neuropharmacology Population Pharmacokinetics of Phenytoin Based on NONMEM in Patients with Intracranial Tumor During the First Week of Post-Craniotomy
Current Drug Metabolism Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology
Current Molecular Medicine The Potential Therapeutic Value of Renin-Angiotensin System Inhibitors in the Treatment of Colorectal Cancer
Current Pharmaceutical Design Towards More Successful Gene Therapy Clinical Trials for β-Thalassemia
Current Molecular Medicine Deciphering the Role of Glutamate Signaling in Glioblastoma Multiforme: Current Therapeutic Modalities and Future Directions
Current Pharmaceutical Design Editorial [ Hot Topic: Targeting Tumor Angiogenesis: An Update (Guest Editor: Girolamo Ranieri)]
Current Medicinal Chemistry mTOR in Growth and Protection of Hypertrophying Myocardium
Cardiovascular & Hematological Agents in Medicinal Chemistry Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review
Anti-Cancer Agents in Medicinal Chemistry Overview of the Structure and Function of Protein Kinases
Current Enzyme Inhibition Microarray Data Analysis to Find Diagnostic Approach and Identify Families of Disease-Altered Genes Based on Rank-Reverse of Gene Expression
Current Bioinformatics The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review
Current Molecular Medicine Ex Vivo Gene Therapy and Vision
Current Gene Therapy Medicinal Chemistry of Indolylglyoxylamide TSPO High Affinity Ligands with Anxiolytic-Like Effects
Current Topics in Medicinal Chemistry Aptamers: Selection, Modification and Application to Nervous System Diseases
Current Medicinal Chemistry Biochemical Markers for Brain Injury Monitoring in Children with or without Congenital Heart Diseases
CNS & Neurological Disorders - Drug Targets