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Review Article

RNA干扰疗法的递送系统：当前技术和局限性

卷 20, 期 5, 2020

页: [356 - 372] 页: 17

弟呕挨: 10.2174/1566523220666201005110726

价格: $65

摘要

近年来，RNA干扰技术因其对多种疾病的治疗潜力而被广泛研究。它旨在通过施用RNA干扰剂来沉默与靶标疾病相关的不想要的基因的表达。但是，这些试剂（核酸）在循环系统中不稳定并且缺乏靶标特异性。因此，药物输送系统对于该技术的成功实施至关重要。已经开发了各种各样的递送系统来克服这些挑战，例如病毒载体，无机药物载体，聚合物载体和基于脂质的载体，但是具有明显的局限性。除现有技术外，新颖，创新的药物输送系统（如可配置的异种机器人）也正在迅速兴起，并有望将生物医学领域推向新的高度。这篇综述总结了药物递送系统和目前用于递送RNAi剂的技术开发中的技术困难，并讨论了其局限性。

关键词: RNA干扰，核酸递送，病毒载体，外来体，白蛋白，脂质体，异种机器人。

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