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Current Neurovascular Research


ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

Research Article

Gender Differences in Characteristics and Outcome in Primary Intraventricular Hemorrhage

Author(s): Rui Guo, Lu Yin, Ruiqi Chen, Liang Zhou, Chao You, Lu Ma and Hao Li*

Volume 16, Issue 4, 2019

Page: [321 - 327] Pages: 7

DOI: 10.2174/1567202616666190906145035

Price: $65


Background: Primary intraventricular hemorrhage (PIVH) is a rare type of Intracerebral Hemorrhage (ICH), which is poorly understood. This study aimed to investigate gender differences in patients' characteristics, management and outcome at discharge and 90 days after PIVH.

Methods: Consecutive patients with PIVH from a single center in China were enrolled over a 7- year period. Gender differences in demographics, risk factors, etiological subtypes, treatment, and outcomes were examined. The logistic regression models were used in the study to identify the predictors of poor outcome.

Results: In total, 174 patients were analyzed, and 77 (44.3%) of them were women. Women with PIVH were younger (p = 0.047), with lower systolic and diastolic blood pressure (p = 0.02 and p = 0.004, respectively). They had more cases caused by Moyamoya disease (p = 0.038). There were fewer patients with hypertension (p = 0.008), smoking (p<0.001), chronic alcoholism (p<0.001), harbored lower hemoglobin (p<0.001) and Absolute Monocyte Count (AMC) (p = 0.04) at admission compared with men. There were no differences between female and male patients regarding the mortality and poor outcome in the multivariable-adjusted models ((OR = 0.57; 95% CI, 0.15-2.14) and (OR = 0.86; 95% CI, 0.32-2.37), respectively). In subgroup analysis after adjustment, the gender specific independent predictors for unfavorable outcome were higher with a Graeb score (OR = 1.78; 95% CI, 1.01-3.13) or AMC (OR = 9.66; 95% CI, 1.20-12.87) in women, and lower Glasgow coma scale (GCS) score (OR = 0.64; 95% CI, 0.47-0.87) or acute hydrocephalus (OR = 0.17; 95% CI, 0.03-0.86) in men.

Conclusion: Women with PIVH exhibit some distinctive baseline features compared with men. The gender difference of the PIVH does not appear to affect the neurological outcome. The predictors of poor outcomes are Graeb score and AMC in women and GCS score and acute hydrocephalus in men.

Keywords: Primary Intraventricular Hemorrhage (PIVH), Intraventricular Hemorrhage (IVH), gender differences, outcome, Intracerebral Hemorrhage (ICH), risk factors.

Gates PC, Barnett HJ, Vinters HV, Simonsen RL, Siu K. Primary intraventricular hemorrhage in adults. Stroke 1986; 17(5): 872-7.
Angelopoulos M, Gupta SR, Azat Kia B. Primary intraventricular hemorrhage in adults: Clinical features, risk factors, and outcome. Surg Neurol 1995; 44(5): 433-6. discussion 7.
Marti-Fabregas J, Piles S, Guardia E, Marti-Vilalta JL. Spontaneous primary intraventricular hemorrhage: Clinical data, etiology and outcome. J Neurol 1999; 246(4): 287-91.
Passero S, Ulivelli M, Reale F. Primary intraventricular haemorrhage in adults. Acta Neurol Scand 2002; 105(2): 115-9.
Flint AC, Roebken A, Singh V. Primary intraventricular hemorrhage: yield of diagnostic angiography and clinical outcome. Neurocrit Care 2008; 8(3): 330-6.
Giray S, Sen O, Sarica FB, et al. Spontaneous primary intraventricular hemorrhage in adults: Clinical data, etiology and outcome. Turk Neurosurg 2009; 19(4): 338-44.
Arboix A, Garcia-Eroles L, Vicens A, Oliveres M, Massons J. Spontaneous primary intraventricular hemorrhage: Clinical features and early outcome. ISRN Neurol 2012; 2012498303
Srivastava T, Sannegowda RB, Satija V, Jain RS, Tejwani S, Mathur T. Primary intraventricular hemorrhage: Clinical features, risk factors, etiology, and yield of diagnostic cerebral angiography. Neurol India 2014; 62(2): 144-8.
Lee SH, Park KJ, Park DH, Kang SH, Park JY, Chung YG. Factors associated with clinical outcomes in patients with primary intraventricular hemorrhage. Med Sci Monit 2017; 23: 1401-12.
Weinstein R, Ess K, Sirdar B, Song S, Cutting S. Primary intraventricular hemorrhage: Clinical characteristics and outcomes. J Stroke Cerebrovasc Dis 2017; 26(5): 995-9.
Di Carlo A, Lamassa M, Baldereschi M, et al. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: Data from a multicenter multinational hospital-based registry. Stroke 2003; 34(5): 1114-9.
Vibo R, Korv J, Roose M. One-year outcome after first-ever stroke according to stroke subtype, severity, risk factors and pre-stroke treatment. A population-based study from Tartu, Estonia. Eur J Neurol 2007; 14(4): 435-9.
Gall SL, Donnan G, Dewey HM, et al. Sex differences in presentation, severity, and management of stroke in a population-based study. Neurology 2010; 74(12): 975-81.
Kong FY, Tao WD, Hao ZL, Liu M. Predictors of one-year disability and death in Chinese hospitalized women after ischemic stroke. Cerebrovasc Dis 2010; 29(3): 255-62.
Appelros P, Stegmayr B, Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke 2009; 40(4): 1082-90.
Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology 1982; 143(1): 91-6.
Gall SL, Tran PL, Martin K, Blizzard L, Srikanth V. Sex differences in long-term outcomes after stroke: Functional outcomes, handicap, and quality of life. Stroke 2012; 43(7): 1982-7.
Niewada M, Kobayashi A, Sandercock PA, Kaminski B, Czlonkowska A. Influence of gender on baseline features and clinical outcomes among 17,370 patients with confirmed ischaemic stroke in the international stroke trial. Neuroepidemiology 2005; 24(3): 123-8.
Oh MS, Yu KH, Roh JK, Lee BC. Gender differences in the mortality and outcome of stroke patients in Korea. Cerebrovasc Dis 2009; 28(5): 427-34.
Hong Y, Yang X, Zhao W, et al. Sex differences in outcomes among stroke survivors with non-valvular atrial fibrillation in China. Front Neurol 2017; 8: 166.
Zheng K, Zhong M, Zhao B, et al. Poor-grade aneurysmal subarachnoid hemorrhage: Risk factors affecting clinical outcomes in intracranial aneurysm patients in a multi-center study. Front Neurol 2019; 10: 123.
Li OL, Silver FL, Lichtman J, et al. Sex differences in the presentation, care, and outcomes of transient ischemic attack: Results from the ontario stroke registry. Stroke 2016; 47(1): 255-7.
Matijevic V, Barbaric B, Kraljevic M, Milas I, Kolak J. Gender differences in neurodevelopmental outcomes among full-term infants with intraventricular hemorrhage. Acta Clin Croat 2019; 58(1): 107-12.
Hung KH, Lai JC, Hsu KN, et al. Gender gap and risk factors for poor stroke outcomes: A single hospital-based prospective cohort study. J Stroke Cerebrovasc Dis 2018; 27(8): 2250-8.
AlQuaiz AM, Siddiqui AR, Qureshi RH, et al. Women health in Saudi Arabia: A review of non-communicable diseases and their risk factors. Pak J Med Sci 2014; 30(2): 422-31.
Haast RA, Gustafson DR, Kiliaan AJ. Sex differences in stroke. J Cereb Blood Flow Metab 2012; 32(12): 2100-7.

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