ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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William A. Banks
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Current: 2.611
5 - Year: 3

Abstracts Ahead of Print

Discrepancies in Animal Models of Preterm Birth


Clarence R. Manuel, Charles R. Ashby and Sandra E Reznik.


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Metabolism of Nucleosides and Nucleotides Prodrugs


Coralie De Schutter, Maryam Ehteshami, Emily T. Hammond, Franck Amblard and Raymond F Schinazi.


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1,N6-ethenoadenine and other Fluorescent Nucleobase Analogues as Substrates for Purine-Nucleoside Phosphorylases: Spectroscopic and Kinetic Studies


Jacek Wierzchowski, Alicja Stachelska-Wierzchowska, Beata Wielgus-Kutrowska and Agnieszka Bzowska.


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Whole cell biocatalysts for the preparation of nucleosides and their derivatives


Elizabeth S. Lewkowicz and Adolfo M Iribarren.


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Schistosoma mansoni purine and pyrimidine biosynthesis: structures and kinetic experiments in the search for the best therapeutic target


Vitor Hugo Balasco Serrão, Humberto D’Muniz Pereira, Juliana Roberta Torini de Souza and Larissa Romanello.


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Mechanistic Understanding of Herbal Therapy in Inflammatory Bowel Disease


Luqing Zhao, Shengsheng Zhang and Peijian He.


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Level V metastasis, a novel predicative factor for recurrence in N1b papillary thyroid carcinoma


Yifeng Wu, Jianjun Li, Xianjiang Wu and Lei Dai.


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Epilepsy, comorbidities and treatments


Alla Guekht.


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PBPK in preterm and term neonates: a review


Robin Michelet, Jan Van Bocxlaer and An Vermeulen.


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A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition


Ahmed Reda, Anke Raaijmakers, Saskia van Dorst, Charlotte G.G.M. Pauwels, Karel Allegaert, Mohamed A Elmonem, Rosalinde Masereeuw, Lambertus van den Heuvel, Elena Levtchenko and Fanny Oliveira Arcolino.


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Statins and inflammation in cardiovascular disease


Georgia Vogiatzi, Evangelos Oikonomou, Gerasimos Siasos, Sotiris Tsalamandris, Alexandros Briasoulis, Emmanuel Androulakis, George Latsios, Spyridon Papaioannou, Konstantinos Tsioufis and Dimitris Tousoulis.


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Overview on inhalable nanocarriers for respiratory immunization


Rui C. Ferreira, Hermenegildo Neves, João F. Pinto and Carla M Lopes.


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Optimising β-lactam Dosing in Neonates: A Review of Pharmacokinetics, Drug Exposure and Pathogens


Aline Fuchs, Grace Li, Johannes Van Den Anker and Julia Bielicki.


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Hypertension in 2017: Update in treatment and pharmaceutical innovations


Mehmet Evren Okur, Ioannis D. Karantas, Neslihan Üstündağ Okur and Panoraia I Siafaka.


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Beneficial Effects of Corn Silk on Metabolic Syndrome


Bing Wang, Tiegang Xiao, Jun Ruan and Wensheng Liu.


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Perivascular adipose tissue as an endocrine organ: the role of statins


Fabio Sanna, Marios Margaritis and Charalambos Antoniades.


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Statins in Peripheral Arterial Disease


Scott T. Chiesa, Nikos Papageorgiou and Marietta Charakida.


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Statins and oxidative stress in the cardiovascular system


Marios Margaritis, Fabio Sanna and Charalambos Antoniades.


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Statins and left ventricular function


Agamemnon Bakakos, Evangelos Oikonomou, Georgia Vogiatzi , Gerasimos Siasos, Sotiris Tsalamandris , Alexios Antonopoulos , Costas Mourouzis, Petros Fountoulakis, Manolis Vavuranakis and Dimitris Tousoulis.


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Developmental pharmacokinetics in neonates: maturational changes and beyond


Karel Allegaert , Paola Mian and John van den Anker.


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Collaboration in Regulatory Science to Facilitate Therapeutic Development for Neonates


Susan K. McCune, Yeruk Ager Mulugeta and Gerri R Baer.


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Maternal immunomodulation therapy for prevention of preterm birth and prematurity-related morbidity: The new era of immuno-perinatology


Shriddha Nayak, Jared Welling and Irina Burd.


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A review of Chinese herbal medicine for the treatment of chronic heart failure


Yong Wang, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu and Wei Wang.


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Development of Peptide Vaccines in Dengue


Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh.


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Effects Of Excitotoxic Lesion With Inhaled Anesthetics On Nervous System Cells Of Rodents


Maria Fernanda Quiroz-Padilla, Gemma Guillazo-Blanch, Magdy Y Sanchez, Maria Andrea Dominguez-Sanchez and Rosa Margaria Gomez.


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Neonatal plasticity of the nociceptive system: mechanisms, effects, and treatment of repetitive painful procedures during NICU admittance


N J Van den Hoogen, J Patijn , D Tibboel and E A Joosten.


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Intravenous paracetamol dosing guidelines for pain management in (pre)term neonates using the paediatric study decision tree


P. Mian, C.A.J. Knibbe, E.A.M. Calvier, D. Tibboel and K Allegaert.


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Big data analyses for continuous evaluation of pharmacotherapy: A proof of principle with doxapram in preterm infants


Robert B. Flint, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit CP Koch, Ronald de Groot, Dick Tibboel, Catherijne AJ Knibbe, Irwin KM Reiss, Sinno HP Simons and DINO Research group.


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Natural active compounds from plant food and Chinese herbal medicine for nonalcoholic fatty liver disease


Qian Liu, Lixin Zhu, Chen Cheng, Yiyang Hu and Qin Feng.


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Chinese herbal medicine for the treatment of depression: applications, efficacies and mechanisms


Yuanyuan Wang, Menglin Li, Yan Liang, Yiting Yang, Zhe Liu, Keyu Yao, Zijie Chen and Shuangqing Zhai.


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Aerosol: a novel vehicle in pharmacotherapy in neonates


Ronan MacLoughlin, Colin Telfer, Andy Clark and James Fink.


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Statins and contrast-induced nephropathy: a systematic review and meta-analysis


Alexandros Briasoulis, Mohan Pala , Tesfaye Telila , Obsinet Merid, Emmanuel Akintoye, Georgia Vogiatzi , Evangelos Oikonomou and Dimitris Tousoulis.


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Pharmacological aspects of neuro-immune interactions


Vadim V. Tarasov, Nikita V. Kudryashov, Vladimir N. Chubarev, Tatiana S. Kalinina, George E. Barreto, Ghulam Md Ashraf and Gjumrakch Aliev.


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The effect of physical exercise on neurogenesis factor production in glial cells


Jorge M. Moreno-Collazos and Eva S Orti.


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Genetic aspects of glial cells regarding neurodegenerative diseases


Julio Cesar Martinez Lozano, Rosa Margarita Gómez, Andres Gabriel Zarate Sanabria, Giovanny Jubiz and Sonia Del Pilar Otalora Valderrama.


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Statins in Stable Angina Pectoris


Adam Ioannou, Nikolaos Papageorgiou , Vincent McVaughan , Marietta Charakida , Dimitris Bertsias , Fay Zacharia, Gerasimos Siasos, George Latsios, Spyridon Papaioannou, Evangelos Oikonomou and Dimitris Tousoulis.


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Graphene-based nanomaterials: potential tools for neurorepair


Qing Wang , Yan-Hua Li, Wei-Jia Jiang, Jian-Guo Zhao, Bao-Guo Xiao , Guang-Xian Zhang and Cun-Gen Ma.


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Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists


Mathieu Nadeau-Vallée, Dima Obari, Alexandra Beaudry-Richard, Estefania Marin Sierra, Alexandre Beaulac, Noémie Maurice, David M. Olson and Sylvain Chemtob.


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Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research


Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen and David M Aronoff.


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An overview of cardenolides in Digitalis - more than a cardiotonic compound


Ekrem Gurel, Serhan Karvar, Buhara Yucesan, Ismail Eker and Muhammad Sameeullah.


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Nasal Delivery of Antioxidants by Cholesterol-incorporated Liposomes Extends the Neuroprotective Time Window in Cerebral Ischemia


Seul Ki Min, Yeo Seon Kwon, Myung Kwon Cho and Hwa Sung Shin.


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The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis


Kenneth Blum, Panayotis K Thanos, Gene-Jack Wang, Marcelo Febo, Zsolt Demetrovics, Edward Justin Modestino, Eric R. Braverman, David Baron, Rajendra D. Badgaiyan and Mark S Gold.


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A novel danshensu-tetramethylpyrazine conjugate DT-018 provides cardioprotection by preserving mitochondrial function through the MEF2D/PGC-1α pathway


Xiaojing Zhang, Jingxiong Luo, Yali Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun, Luchen Shan and Yuqiang Wang.


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Genetic variants of PEAR1 are associated with platelet function and antiplatelet drug efficacy: a systematic review and meta-analysis


Qian Xiang, Shuang Zhou, Joshua P. Lewis, Alan R. Shuldiner, Guanhua Ren and Yimin Cui.


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Biomarkers of cardiovascular risk in haemodialysis patients


Beata Franczyk, Anna Gluba-Brzózka and Jacek Rysz.


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Statins in acute coronary syndromes


Manolis Vavuranakis, Maria Kariori, Gerasimos Siasos, Konstantinos Kalogeras and Dimitris Tousoulis.


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Statins in Aortic Stenosis


Karl Norrington, Emmanuel Androulakis, Evangelos Oikonomou, Georgia Vogiatzi and Dimitris Tousoulis.


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The therapeutical effect of Chinese medicine for the treatment of atherosclerotic coronary heart disease


Jian Zhang , Hui Meng, Yi Zhang , Xuefeng Zhang , MingYan Shao, Chun Li and Pengfei Tu.


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Current Strategies to Improve the Target of Cell Penetrating Peptides used for Antitumor Therapeutics


Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He and Peng Zhang.


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Pharmacology and literature review based on related death and non-fatal case reports of the benzofurans and benzodifurans designer drugs.


Bernardino Barceló Martín and Isabel Gomila.


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Update of Standard Practices for New Method Validation in Forensic Toxicology


Sarah M.R. Wille, Wim Coucke, Thierry De Baere and Frank T Peters.


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Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity


Josivan da Silva Costa, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo.


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Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview


Natalia Dementeva, Daria Kokova and Oleg A Mayboroda.


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Recent Advances in Targeting the HIV-1 Tat/TAR Complex


Fardokht A. Abulwerdi and Stuart FJ Le Grice.


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Mephedrone Concentrations in Cases of Clinical Intoxication


Esther Papaseit, Eulàlia Olesti, Rafael de la Torre, Marta Torrens and Magí Farré.


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“Stress” is 80 years old: From Hans Selye original paper in 1936 to recent advances in GI ulceration


Sandor Szabo, Masashi Yoshida, Janos Filakovszky and Gyorgy Juhasz.


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Interest of single hair analysis to document drug exposure: literature review and a case report involving zuclopenthixol


Nathalie Allibe, Pascal Kintz, Amandine Faure, François Paysant, Anne-Pascale Michard-Lenoir, Françoise Stanke-Labesque, Virginie Scolan and Hélène Eysseric-Guerin.


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Icariin Attenuates Interleukin-1β-Induced Inflammatory Response in Human Nucleus Pulposus Cells


Wen-bin Hua, Yu-kun Zhang, Xing-huo Wu, Liang Kang, Ji Tu, Kang-cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-jin Luo, Zeng-wu Shao and Cao Yang.


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Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs


Banu Bayram, Aykut Özgür, Lütfi Tutar and Yusuf Tutar.


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Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells


Byeong Mo Kim, Wonsuck Yoon, Jung-Hyun Shim, Haiyoung Jung, Ji Hong Lim, Hyun-Jung Choi, MiRan Seo, Tae Ho Lee and Sang-Hyun Min.


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How to treat patients with essential hypertension and peripheral arterial disease.


Salvatore Santo Signorelli.


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Nanovesicular formulations for cancer gene therapy


Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo.


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Long-lasting insulin treatment via a single subcutaneous administration of liposomes in thermoreversible Pluronic® F127 based hydrogel


Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu and Zhijun Yang.


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Anti-cancer drug delivery using carbohydrate-based polymers


Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi and Mohammad Ramezani.


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Approaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets


George E. Barreto , Rosa M. Gómez, Rosa Helena Bustos, Diego A. Forero, Gjumrakch Aliev, Jerzy Leszek, Valentina Echeverria and Janneth Gonzalez.


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Synthesis and characterization of a new benzo indole derivative with apoptotic activity against colon cancer cells


Fatemeh Hajiaghaalipou, Fadhil Lafta Faraj, Elham Bagheri, Hamid Khaledi, Hapipah Mohd Ali, Nazia Abdul Majid and Mahmood Ameen Abdulla.


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