ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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  • 117th of 256 in Pharmacology & Pharmacy

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Current: 2.611
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Abstracts Ahead of Print

A novel danshensu-tetramethylpyrazine conjugate DT-018 provides cardioprotection by preserving mitochondrial function through the MEF2D/PGC-1α pathway


Xiaojing Zhang, Jingxiong Luo, Yali Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun, Luchen Shan and Yuqiang Wang.


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Effects Of Excitotoxic Lesion With Inhaled Anesthetics On Nervous System Cells Of Rodents


Maria Fernanda Quiroz Padilla, Gemma Guillazo-Blanch, Magdy Sanchez , Maria Andrea Dominguez and Rosa Margaria Gomez.


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Genetic variants of PEAR1 are associated with platelet function and antiplatelet drug efficacy: a systematic review and meta-analysis


Qian Xiang, Shuang Zhou, Joshua P. Lewis, Alan R. Shuldiner, Guanhua Ren and Yimin Cui.


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Neuroglial cell cryopreservation in appropriate inductive conditions


Rosa M. Gomez, Maria Andrea Dominguez-Sanchez, Magdy M. Sanchez and George E Barreto.


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Biomarkers of cardiovascular risk in haemodialysis patients


Beata Franczyk, Anna Gluba-Brzózka and Jacek Rysz.


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Nanotechnology In Neurosciences: An Approach


Rosa Helena Bustos Cruz, Magdy M. Sanchez, Maria Andrea Dominguez-Sanchez, George E. Barreto, Daniel Lancheros and Jorge Reynolds.


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Statins in acute coronary syndromes


Manolis Vavuranakis, Maria Kariori, Gerasimos Siasos, Konstantinos Kalogeras and Dimitris Tousoulis.


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Statins in Diabetes Mellitus


Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, George Lazaros and Dimtris Tousoulis.


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Statins in Aortic Stenosis


Karl Norrington, Emmanuel Androulakis, Evangelos Oikonomou, Georgia Vogiatzi and Dimitris Tousoulis.


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Treatment of epileptic encephalopathies


Simona Balestrini and Sanjay M Sisodiya.


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Safety profile of the newest antiepileptic drugs: a curated literature review


Caterina Palleria, Giuseppe Cozza, Rajeshree Khengar, Vincenzo Libri and Giovambattista De Sarro.


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Update on pharmacological treatment of Progressive Myoclonus Epilepsies.


Edoardo Ferlazzo, Dorothee Kasteleijn-Nolst Trenite, Gerrit-Jan de Haan, Felix Felix Nitschke, Saija Ahonen, Sara Gasparini and Berge A Minassian.


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Imaging Biomarkers of Anti-Epileptic Drug Action: Insights from Magnetic Resonance Imaging


Lorenzo Caciagli, Fenglai Xiao, Britta Wandschneider and Matthias J Koepp.


View Abstract


Antiepileptic treatments in developing countries


Jeremy Jost, Athanase Millogo and Pierre-Marie Preux.


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Ketogenic diets in the treatment of epilepsy


Maurizio Elia, Joerg Klepper, Baerbel Leiendecker and Hans Hartmann.


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Antiepileptic drugs in clinical development: differentiate or die?


Gaetano Zaccara and D Schmidt.


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Modulation of GABAA receptors in the treatment of epilepsy


Eleonora Palma, Gabriele Ruffolo, Pierangelo Cifelli, Cristina Roseti, Erwin A. van Vliet and Eleonora Aronica.


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Neuroprotection in hypoxic-ischemic brain injury targeting glial cells


María Inés Herrera, Sofia Mucci, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani.


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The therapeutical effect of Chinese medicine for the treatment of atherosclerotic coronary heart disease


Jian Zhang , Hui Meng, Yi Zhang , Xuefeng Zhang , MingYan Shao, Chun Li and Pengfei Tu.


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Current Strategies to Improve the Target of Cell Penetrating Peptides used for Antitumor Therapeutics


Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He and Peng Zhang.


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Biotin and glutathione targeting of solid nanoparticles to cross human brain endothelial cells


Szilvia Veszelka, Mária Mészáros, Lóránd Kiss, Zoltán Kóta, Tibor Páli, Zsófia Hoyk, Zsolt Bozsó, Lívia Fülöp, András Tóth, Gábor Rákhely and Mária A Deli.


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MiRNA-based therapeutic strategy in lung cancer


Guang Li, Jing Fang, Ying Wang, Hu Wang and Cheng-Cao Sun.


View Abstract


Protein kinases as tumor biomarkers and therapeutic targets


Chuntao Quan, Juanjuan Xiao, Lin Liu, Qiuhong Duan, Ping Yuan and Feng Zhu.


View Abstract


Application Of Kinase Inhibitors For Anti-Aging Intervention


Mercedes Cano, Antonio Ayala, Francesco Marotta and Sandro Argüelles.


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Role of the immune component of tumor microenvironment in the efficiency of cancer treatment: perspectives for the personalized therapy


Marina Stakheyeva, Vladimir Riabov, Irina Mitrofanova, Nikolai Litviakov, Evgeny Choynzonov, Nadezhda Cherdyntseva and Julia Kzhyshkowska.


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Pharmacology and literature review based on related death and non-fatal case reports of the benzofurans and benzodifurans designer drugs.


Bernardino Barceló Martín and Isabel Gomila.


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Update of Standard Practices for New Method Validation in Forensic Toxicology


Sarah M.R. Wille, Wim Coucke, Thierry De Baere and Frank T Peters.


View Abstract


Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer


Feng-Yun Gong, Tao Bai, Ding-Yu Zhang, Chao-lin Huang, Jing Lv, Jing-Li Wang, Xu-Dong Hu, Juan Wang and Wei Liu.


View Abstract


MiRNA-based therapeutics for lung cancer


Miaowei Wu, Guosheng Wang, Wei Tian, Yongchuan Deng and Yibing Xu.


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Role of miRNA in lung cancer-potential biomarkers and therapies


Xiaohong Du, Jitai Zhang, Juping Wang, Xiaoming Lin and Feng Ding.


View Abstract


GSK3 inhibitors in the therapeutic development of diabetes, cancer and Neurodegeneration: Past, present and future


Mudasir Maqbool and Nasimul Hoda.


View Abstract


Virtual screening and statistical analysis in the design of new caffeine analogues molecules with potential epithelial anticancer activity


Josivan da Silva Costa, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo.


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Supramolecular self-assembled nanogels a new platform for anticancer drug delivery


Jaleh Varshosaz, Somayeh Taymouri and Erfaneh Ghassami.


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Identification of antineoplastic targets with systems approaches, using resveratrol as an in-depth case study


Nivedita Singh, Sherry Freiesleben, Shailendra K. Gupta, Yogeshwer Shukla and Olaf Wolkenhauer.


View Abstract


Modulation of heart rate by acute or chronic aerobic exercise. Potential effects on blood pressure control


Carme Perez-Quilis, J. Derek Kingsley, Kabir Malkani, Gianfranco Cervellin, Giuseppe Lippi and Fabian Sanchis-Gomar.


View Abstract


Targeting Protein Kinases for the Treatment of Glioblastoma Multiforme:Linking Basic Studies to Clinical Applications


Aidong Zhou.


View Abstract


DNA base excision repair: the Achilles’ heel of tumour cells and their microenvironment?


M Poletto , A J Legrand and G L Dianov.


View Abstract


Protein Kinase Inhibitors as Potential Antimicrobial Drugs against Tuberculosis, Malaria and HIV


Yong Cheng, Jeffrey S. Schorey, Cheng-Cai Zhang and Xuejuan Tan.


View Abstract


Studying Interactions of Drugs with Cell Membrane Nutrient Transporters: New Frontiers of Proteoliposome Nanotechnology


Mariafrancesca Scalise, Michele Galluccio, Lorena Pochini, Lara Console, Maria Barile, Nicola Giangregorio, Annamaria Tonazzi and Cesare Indiveri.


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Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview


Natalia Dementeva, Daria Kokova and Oleg A Mayboroda.


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Recent Advances in Targeting the HIV-1 Tat/TAR Complex


Fardokht A. Abulwerdi and Stuart FJ Le Grice.


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Mephedrone Concentrations in Cases of Clinical Intoxication


Esther Papaseit, Eulàlia Olesti, Rafael de la Torre, Marta Torrens and Magí Farré.


View Abstract


Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils


Sandra Völs, Ronit Vogt Sionov and Zvi Granot.


View Abstract


Prevalence and surveillance of synthetic cathinones use by hair analysis: an update review


JC. Alvarez, N. Fabresse and IA Larabi.


View Abstract


Good Practices in Forensic Toxicology


Olaf H Drummer.


View Abstract


Nails in Forensic Toxicology: an Update


Renata Solimini, Adele Minutillo, Chrystalla Kyriakou , Simona Pichini, Roberta Pacifici and Francesco Paolo Busardò.


View Abstract


Method development in Forensic Toxicology


Frank T. Peters, Dirk K. Wissenbach, Francesco Paolo Busardò, Emilia Marchei and Simona Pichini.


View Abstract


Role of bradykinin in the regulation of endothelial nitric oxide synthase expression by cardiovascular drugs


Jin Bo Su.


View Abstract


Zein-based nanocarriers as potential natural alternatives for drug and gene delivery: Focus on cancer therapy


Ahmed Elzoghby, May Freag, Hadeer Mamdouh and Kadria Elkhodairy.


View Abstract


“Stress” is 80 years old: From Hans Selye original paper in 1936 to recent advances in GI ulceration


Sandor Szabo, Masashi Yoshida, Janos Filakovszky and Gyorgy Juhasz.


View Abstract


LSD detection and interpretation in hair


Camille Richeval, Delphine Allorge, X. Vanhoye and Jean-michel Gaulier.


View Abstract


Overview Of Forensic Toxicology, Yesterday, Today And In The Future


Heesun Chung and Sanggil Choe.


View Abstract


Interest of single hair analysis to document drug exposure: literature review and a case report involving zuclopenthixol


Nathalie Allibe, Pascal Kintz, Amandine Faure, François Paysant, Anne-Pascale Michard-Lenoir, Françoise Stanke-Labesque, Virginie Scolan and Hélène Eysseric-Guerin.


View Abstract


Membrane-bound ATP-dependent Energy Systems, as Extra- and Intracellular Key Signals for Gastrointestinal Functions and their Regulations in the Gastrointestinal Mucosa


Gyula Mózsik, Imre László Szabó and József Czimmer.


View Abstract


Icariin Attenuates Interleukin-1β-Induced Inflammatory Response in Human Nucleus Pulposus Cells


Wen-bin Hua, Yu-kun Zhang, Xing-huo Wu, Liang Kang, Ji Tu, Kang-cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-jin Luo, Zeng-wu Shao and Cao Yang.


View Abstract


Albumin nanocarriers, γ - irradiated crosslinked, combined with therapeutic drugs for cancer therapy


Macarena Siri, Estefanía Achilli, Mariano Grasselli and Silvia del V Alonso.


View Abstract


Management of blood pressure and heart rate in patients with diabetes mellitus


Ioanna Gouni-Berthold, Ruth Hanssen, Lisa Ravarani and Heiner K Berthold.


View Abstract


Sialidases: Therapeutic and Antiatherogenic Potential


Vasily Nikolaevich Sukhorukov , Vasily Petrovich Karagodin , Emile Rustemovich Zakiev , Andrey Vyacheslavovich Grechko and Alexandr Nikolaevich Orekhov.


View Abstract


Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs


Banu Bayram, Aykut Özgür, Lütfi Tutar and Yusuf Tutar.


View Abstract


Why Not All Hypertensive Patients Are Tachycardic at Rest?


Maciej Siński, Piotr Jędrusik and Jacek Lewandowski.


View Abstract


What Is The Real Efficacy Of Beta-Blockers For The Treatment Of Essential Hypertension?


Christian Höcht, Facundo M Bertera, Julieta S Del Mauro, Yanina Santander Plantamura, Carlos A Taira and Ariel H Polizio.


View Abstract


Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells


Byeong Mo Kim, Wonsuck Yoon, Jung-Hyun Shim, Haiyoung Jung, Ji Hong Lim, Hyun-Jung Choi, MiRan Seo, Tae Ho Lee and Sang-Hyun Min.


View Abstract


How to treat patients with essential hypertension and peripheral arterial disease.


Salvatore Santo Signorelli.


View Abstract


Formulation, Quality Control and Safety Issues of Nanocarriers Used For Cancer Treatment


Ismael D. Bianco, Marcelo R. Ceballos, Cristian Casado, Viviana G. Dabbene, Carolina Rizzi and R Kiyomi Mizutamari.


View Abstract


Anthocyanins: Possible role as Multitarget therapeutic agents for prevention and therapy of chronic diseases


Swathi Putta, Nagendra Sastry Yarla, Ilaria Peluso, Dinesh Kumar Tiwari, Gorla V.Reddy, Priyanka Voori Giri, Naresh Kumar, Ramarao Malla, Veera Brahma Chari, Rama Sekhara Reddy D, Ramesh Bade, Mastan Mannarapu, George Barretto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico Fávaro Ribeiro, Luciana Scotti, Marcus T. Scotti, M. A.Kamal, Gjumrakch Aliev, Chinthalapally V. Rao, George Perry and Anupam Bishayee.


View Abstract


Synthesis and biological evaluation of new tyrosol-salicylate derivatives as potential anti-inflammatory agents


Rafael P. Aguiar, Fahad S. Aldawsari, Luiz A. M. Wiirzler, Saulo E. Silva- Filho, Francielli M. S. Silva-Comar, Ciomar A. Bersani-Amado, Carlos A. Velázquez-Martínez and Roberto K N Cuman.


View Abstract


Effect of magnesium supplementation on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials.


Luis E. Simental-Mendía, Amirhossein Sahebkar, Martha Rodríguez-Morán, Graciela Zambrano-Galván and Fernando Guerrero-Romero.


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Using properties of tumor microenvironments for controlling local, on-demand delivery from biopolymer-based nanocarriers.


Abdullah K. Alshememry, Suleiman S. El-Tokhy and Larry D Unsworth.


View Abstract


Pivotal roles of Interleukin-17 as the Epicenter of Bone Loss Diseases


Chongshan Liao, Chengfei Zhang and Yanqi Yang.


View Abstract


Hybrid polymeric-magnetic nanoparticles in cancer treatments


Alexandra Muñoz Bonilla and Pilar Herrasti González.


View Abstract


Nanovesicular formulations for cancer gene therapy


Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo.


View Abstract


Long-lasting insulin treatment via a single subcutaneous administration of liposomes in thermoreversible Pluronic® F127 based hydrogel


Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu and Zhijun Yang.


View Abstract


Anti-cancer drug delivery using carbohydrate-based polymers


Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi and Mohammad Ramezani.


View Abstract


Percutaneous treatment of aortic valve disease: contemporary overview and future trends


Marko Banovic, Jozef Bartunek, Serge D. Nikolic, Vladan Vukcevic, Srdjan Aleksandric and Bernard Iung.


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The role of exosomes and exosome-derived microRNAs in atherosclerosis


Xinjie Lu.


View Abstract


Approaches of the transcriptomic analysis in astrocytes: Potential pharmacological targets


George E. Barreto , Rosa M. Gómez, Rosa Helena Bustos, Diego A. Forero, Gjumrakch Aliev, Jerzy Leszek, Valentina Echeverria and Janneth Gonzalez.


View Abstract


Synthesis and characterization of a new benzo indole derivative with apoptotic activity against colon cancer cells


Fatemeh Hajiaghaalipou, Fadhil Lafta Faraj, Elham Bagheri, Hamid Khaledi, Hapipah Mohd Ali, Nazia Abdul Majid and Mahmood Ameen Abdulla.


View Abstract


Diabetes-related neurological implications and pharmacogenomics


Rojas Carranza Camilo Andrés, Bustos Cruz Rosa Helena, Pino Pinzón Carmen Juliana , Ariza Marquez Yeimy Viviana, Gómez Bello Rosa Margarita and Cañadas Garre Marisa.


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Medicinal plants as protective strategies against Parkinson’s Disease


Natalia Areiza Mazo, Valentina Echeverria, Ricardo Cabezas, Marco Ávila-Rodriguez, Gjumrakch Aliev, Jerzy Leszek and George E Barreto.


View Abstract


Implications of photophysical and physicochemical factors on successful application of photodynamic therapy


Shubhajit Paul, Paul Wan Sia Heng and Lai Wah Chan.


View Abstract


Mur Ligase Inhibitors as Anti-bacterials: A Comprehensive Review


Jaiprakash N. Sangshetti, Suyog S. Joshi, Rajendra H. Patil and Devanand B Shinde.


View Abstract


Optimal Pre-treatment for Acute Exposure to the Organophosphate Dicrotophos


Dietrich Ernst Lorke, Syed M. Nurulain, Mohamed Y. Hasan, Kamil Kuča and Georg A Petroianu.


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