E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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  • 117th of 256 in Pharmacology & Pharmacy

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Articles Ahead of Print

Management of Blood Pressure and Heart Rate in Patients with Acute Stroke


Carlo Maida, Antonino Tuttolomondo, Domenico Di Raimondo and Antonio Pinto.


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Molecular Targeting of ERKs/RSK2 Signaling in Cancers


Yong-Yeon Cho.


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The Lipid-Lowering Effects and Associated Mechanisms of Dietary Phytosterol Supplementation


Jerad H Dumolt and Todd C Rideout.


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Biomaterials and Supercritical Fluid Technologies: Which Perspectives to Fabricate Artificial Extracellular Matrix?


Della Porta Giovanna, E. Reverchon and N Maffulli.


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Current and Emerging Strategies in Osteoporosis Management


Stefka Ivanova and Liliya Vasileva.


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Hydrogel-Based Cell Therapies for Kidney Regeneration: Current Trends in Biofabrication and In Vivo Repair


Katja Jansen, Carl C.L. Schuurmans, Jitske Jansen, Rosalinde Masereeuw and Tina Vermonden.


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Hybrid Materials and Nanocomposites as Multifunctional Biomaterials


Heveline D. M. Follmann, Alliny F. Naves, Rafael A. Araujo, Viktor Dubovoy, Xiaoxi Huang, Tewodros Asefa, Rafael Silva and Osvaldo N Oliveira.


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Biohybrid Membrane Systems for Testing Molecules and Stem Cell Therapy in Neuronal Tissue Engineering


Sabrina Morelli, Antonella Piscioneri, Simona Salerno, Enrico Drioli and Loredana De Bartolo.


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Effects of Oral and Non-Insulin Injectable Antidiabetic Treatment in Hypertension: A Systematic Review


Vasiliki Katsi, Georgios Georgiopoulos, Georgia Vogiatzi, Dimitrios Oikonomou, Maria Megapanou, John Skoumas, Charalampos Vlachopoulos, Petros Nihoyannopoulos and Dimitris Tousoulis.


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The Role of Stress in Inflammatory Bowel Diseases


Dolores Sgambato, Agnese Miranda, Rocco Ranaldo, Alessandro Federico and Marco Romano.


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Molecular Tests for the Choice of Cancer Therapy


Anna P. Sokolenko and Evgeny N Imyanitov.


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Recent Advances in the Function of the 67 kDa Laminin Receptor and its Targeting for Personalized Therapy in Cancer


Ada Pesapane, Pia Ragno, Carmine Selleri and Nunzia Montuori.


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Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery


Trevor Clancy, Ruth Dannenfelser, Olga Troyanskaya, Karl Johan Malmberg, Eivind Hovig and Vessela Kristensen.


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Vitamins in Heart Failure: Friend or Enemy?


George Georgiopoulos, Christina Chrysohoou, Georgia Vogiatzi , Nikolaos Magkas, Ippokratis Bournelis, Sofia Bampali, Damien Gruson and Dimitris Tousoulis.


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Aquaporin 4 in Astrocytes is a Target for Therapy in Alzheimer's Disease


Yu-Long Lan, Jian-Jiao Chen, Gang Hu, Jun Xu, Ming Xiao and Shao Li.


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AMPK: Therapeutic Target for Diabetes and Cancer Prevention


Shotaro Umezawa , Takuma Higurashi and Atsushi Nakajima.


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New Strategies for the Prevention and Treatment of Systemic and Local Bone Loss; from Pathophysiology to Clinical Application


A. Fassio, Maurizio Rossini , Ombretta Viapiana, Luca Idolazzi, Camilla Benini, Elisabetta Vantaggiato and Davide Gatti.


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Gene Delivery with Organic Electronic Biomaterials


Kathryn Frances Anne Clancy and John George Hardy.


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Altered Homeostatic Functions in Reactive Astrocytes and Their Potential as a Therapeutic Target After Brain Ischemic Injury


Helena Pivonkova and Miroslava Anderova.


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Targeting Human Astrocytes’ Calcium-sensing Receptors for Treatment of Alzheimer’s Disease


Anna Chiarini, Ubaldo Armato, James F. Whitfield and Ilaria Dal Pra.


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Astrocyte: An Innovative Approach for Alzheimer's Disease Therapy


Maria Rosanna Bronzuoli, Roberta Facchinetti, Luca Steardo and Caterina Scuderi.


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Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease


Ikuko Miyazaki and Masato Asanuma.


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Oncostatin M: Potential Implications for Malignancy and Metabolism


Jacqueline M. Stephens and Carrie M Elks.


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Emerging Targets to Relieve Fat Stress-Induced Liver Diseases: UDCA, Tocotrienol, ω-3 PUFAs, and IgY Targeted NPC1L1 Cholesterol Transporter


Ji-Young Cha, Jong-Min Park, Ho-Jae Lee, Jin-Sik Bae, Young-Min Han, Byung-Chul Oh, Kwang Hyun Ko and Ki-Baik Hahm.


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Class A GPCRs: Structure, Function, Modeling and Structure-based Ligand Design


Xiaojing Cong, Jérémie Topin and Jérôme Golebiowski.


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The Tat/P-TEFb Protein-Protein Interaction Determining Transcriptional Activation of HIV


Kaori Asamitsu and Takashi Okamoto.


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Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) as a Target for Concurrent Management of Diabetes and Obesity-Related Cancer


Mustapha Umar Imam, Qingqing Wang, Zhang Yida and Fudi Wang.


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PTEN, Insulin Resistance, and Cancer


Aiqing Li, Minzi Qiu, Hongbo Zhou, Tao Wang and Wen Guo.


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Plasmodial Hsp40s: New Avenues for Antimalarial Drug Discovery


Michael O Daniyan and Gregory L Blatch.


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Circadian MicroRNAs in Cardioprotection


Yoshimasa Oyama, Colleen Marie Bartman, Jennifer Gile and Tobias Eckle.


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Recent Advances in Polymeric Nanosystems for Treating Cutaneous Melanoma and Its Metastasis


Yi-Ping Chou, Yin-Ku Lin, Chun-Han Chen and Jia-You Fang.


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Are Markers of Cardiac Dysfunction Useful in the Assessment of Cardiovascular Risk in Dialysis Patients?


Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach and Jacek Rysz.


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Protein Kinase Inhibitors as Therapeutic Drugs in AML: Advances and Challenges


Yuan Ling, Zikang Zhang, Hua Zhang and Zunnan Huang.


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Sulfated Glycans in HIV Infection and Therapy


Vitor H. Pomin, Francisco F. Bezerra and Paulo AG Soares.


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Potential Application of 5-Aryl-Substituted 2-Amino-benzamide Type of HDAC1/2- Selective Inhibitors to Pharmaceuticals


Shinichi Uesato, Yoshiyuki Hirata and Tsutomu Sasaki.


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Multimodality Imaging for Interventional Cardiology


Simona Celi, Nicola Martini, Luigi Emilio Pastormerlo, Vincenzo Positano and Sergio Berti.


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Role of Polyamines in Parasite Cell Architecture and Function


Marcos A. Vannier-Santos and Ana M Suarez-Fontes.


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Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets


María Elizbeth Alvarez-Sánchez, José Luis Villalpando, Laura Itzel Quintas-Granados and Rossana Arroyo.


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miR-126 as a Therapeutic Agent for Diabetes Mellitus


Elham Pishavar and Javad Behravan.


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Antidiabetic Drugs and the Kidney


Moses Elisaf, Eleftheria Tzavela, Nikolaos Karanatsis and Vasilis Tsimihodimos.


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Targeting Astrocytes for Treating Neurological Disorders: Carbon Monoxide and Noradrenaline-Induced Increase in Lactate


Anemari Horvat, Nina Vardjan and Robert Zorec.


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Post Mortem Redistribution of Drugs: Current State of Knowledge


Caroline Sastre, Christophe Bartoli, Valerie Baillif-Couniou, Georges Leonetti and Anne-Laure Pelissier-Alicot.


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Functional Nanoparticles and their Interactions with Mesenchymal Stem Cells


Weiwei Wang, Zijun Deng, Xun Xu , Zhengdong Li, Friedrich Jung, Nan Ma and Andreas Lendlein.


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Metallothionein is a Potential Therapeutic Strategy for Amyotrophic Lateral Sclerosis


Shin-ichi Ono.


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Recent Advances on the Role of microRNAs in Both Insulin Resistance and Cancer


Adele Vivacqua, Paola De Marco, Antonino Belfiore and Marcello Maggiolini.


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GLT-1 Upregulation as a Potential Therapeutic Target for Ischemic Brain Injury


Yu-Yan Hu, Li Li, Xiao-Hui Xian, Min Zhang, Xiao-Cai Sun, Shu-Qin Li, Xin Cui, Jie Qi and Wen-Bin Li.


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Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis


Mariana Pehar, Benjamin A. Harlan, Kelby M. Killoy and Marcelo R Vargas.


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Trimethylamine N-oxide (TMAO) as a New Potential Therapeutic Target for Insulin Resistance and Cancer


Jens Oellgaard, Signe Abitz Winther, Tobias Schmidt Hansen, Peter Rossing and Bernt Johan von Scholten.


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Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy


Anna Zajakina, Karina Spunde and Kenneth Lundstrom.


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Using β-Amino Acids and β-Peptide Templates to Create Bioactive Ligands and Biomaterials


Mark P Del Borgo, Ketav Kulkarni and Marie-Isabel Aguilar.


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Chemokine Like Receptor- 1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer


Sangeetha Perumalsamy, Nurul Ain Aqilah Mohd Zin, Riyanto Teguh Widodo, Wan Azman Wan Ahmad, Shireene Ratna DB Vethakkan and Hasniza Zaman Huri.


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Astrocytes Pathology in ALS: A Potential Therapeutic Target?


Sonja Johann.


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Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis


Mina Perić, Dinko Mitrečić and Pavle R Andjus.


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Hydroxyapatite as a Nanomaterial for Advanced Tissue Engineering and Drug Therapy


Juha Tuukkanen and Miho Nakamura.


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Targeting the Tumor Microenvironment by Intervention in Interleukin-1 Biology


Elena Voronov and Ron N Apte.


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Alginate-Based Cell Microencapsulation for Tissue Engineering and Regenerative Medicine


Vittoria Pandolfi, Ulysse Pereira, Murielle Dufresne and Cécile Legallais.


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Tumor Reversion: Mesenchymal-Epithelial Transition as a Critical Step in Managing the Tumor-Microenvironment Cross-Talk


Mariano Bizzarri, Alessandra Cucina and Sara Proietti.


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Obesity-Induced Hypertension: New Insights


Christina Antza, Stella Stabouli, Michalis Natsis, Ioannis Doundoulakis and Vasilios Kotsis.


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Adiponectin as a Potential Therapeutic Target for Prostate Cancer


Hanuma Kumar Karnati, Manas Kumar Panigrahi, Yazhou Li, David Tweedie and Nigel H Greig.


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Effect of Intranasal Administration of Galanin-like Peptide (GALP) on Body Weight and Hepatic Lipids Accumulation in Mice with Diet-induced Obesity


Satoshi Hirako, Nobuhiro Wada, Haruaki Kageyama, Fumiko Takenoya, Hyounju Kim, Yuzuru Iizuka, Akiyo Matsumoto, Mai Okabe and Seiji Shioda.


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From Tendon Injury to Collagen-Based Tendon Regeneration: Overview and Recent Advances


Clément Rieu, Lise Picaut, Gervaise Mosser and Léa Trichet.


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Tissue Engineered Skin and Wound Healing: Current Strategies and Future Directions


Nandana Bhardwaj, Dimple Chouhan and Biman B Mandal.


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The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity


Shuni Wang, Yibing Wang, Jiang Wang, Tatsunori Sato, Kunisuke Izawa, Vadim A. Soloshonok and Hong Liu.


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Engineered Bone Tissue with Naturally-Derived Small Molecules


Guleid Awale, Edgar Wong, Komal Rajpura and Kevin W-H Lo.


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Therapeutic Potential of Heme Oxygenase-1/carbon Monoxide System Against Ischemia-reperfusion Injury


Yuanyuan Cheng and Jianhui Rong.


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Hormones and Sarcopenia


John E Morley.


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Parasite Polyamines as Pharmaceutical Targets


Sigrid Roberts and Buddy Ullman.


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Micro-RNA Profiling as a Predictor of Clinical Outcomes for Head and Neck Cancer Patients


Tatyana Isayeva, Margaret Brandwein-Gensler , Maheshika Somarathna , Lakisha D Moore-Smith and Timmy Lee.


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Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer


Jack Tuszynski, Tatiana M. Tilli and Michael Levin.


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The Chemo-Biological Outreach of Nano-Biomaterials: Implications for Tissue Engineering and Regenerative Medicine


Pradeep Kumar, Yahya E. Choonara, Riaz A. Khan and Viness Pillay.


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Effect and Mechanism of Curcumin on EZH2 – miR-101 Regulatory Feedback Loop in Multiple Myeloma


Chuanqing Wu, Tuo Ruan, Weizhen Liu, Xiaojie Zhu, Juan Pan, Wen Lu, Chen Yan, Kaixiong Tao , Weikang Zhang and Chun Zhang.


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Olfactory Loss Management in View of Avicenna: Focus on Neuroprotective Plants


Farnaz Sinaei, Seyed Ahmad Emami, Amirhossein Sahebkar and Behjat Javadi.


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Microbubbles: A Novel Strategy for Chemotherapy


Mu-hua Luo, Chih-Kuang Yeh, Bing Situ, Jin-sui Yu, Bing-cheng Li and Zhi-yi Chen.


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Application of Bone Marrow Stem Cell Based Therapy in Bone Loss Diseases


Nan Xiao.


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Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications


Sally Sabra, Mona Abdelmoneem, Mahmoud Abdelwakil, Moustafa Taha Mabrouk, Doaa Anwar, Rania Mohamed, Sherine Khattab, Adnan Bekhit, Kadria Elkhodairy, May Freag and Ahmed Elzoghby.


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Bone-Muscle Crosstalk: Unraveling New Therapeutic Targets for Osteoporosis


Anna Picca, Riccardo Calvani, Ester Manes-Gravina, Leonardo Spaziani, Francesco Landi, Roberto Bernabei and Emanuele Marzetti.


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Hyaluronate-Lipid Nanohybrids: Fruitful Harmony in Cancer Targeting


May S Freag.


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Micelles As Delivery System for Cancer Treatment


Dilek Keskin and Ayşen Tezcaner.


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Management of Blood Pressure and Heart Rate in Acute Decompensated Heart Failure with Volume Overload


Duygu Kocyigit, Kadri Murat Gurses, Muhammed Ulvi Yalcin and Lale Tokgozoglu.


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Ligand-modified Biopolymeric Nanoparticles as Efficient Tools for Targeted Cancer Therapy


Hasan Kouchakzadeh, Tooba Soudi, Niloofar Heshmati Aghda and Seyed Abbas Shojaosadati.


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Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds


Maria Yanez, James Blanchette and Ehsan Jabbarzadeh.


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Biomorphic Ceramics for Drug Delivery in Bone Tissue Regeneration


Patricia Diaz-Rodriguez and Mariana Landin.


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Bioresponsive Injectable Hydrogels for On-demand Drug Release and Tissue Engineering


Arti Vashist, Ajeet Kaushik, Kayla Alexis, Rahul Dev Jayant, Vidya Sagar, Atul Vashist and Madhavan Nair.


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Pharmacological Treatment of Bone Loss


Rui Pang and Weibo Xia.


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‘Osteoimmunology’ Offers New Perspectives for the Treatment of Pathological Bone Loss


Hongrui Liu, Tingting Luo, Jiali Tan, Minqi Li and Jie Guo.


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Nanotechnology: A Promising Tool Towards Wound Healing


Thaís Alberti, Daniela S. Coelho, Ana Voytena, Heloísa Pitz, Manuel de Prá, Letícia Mazzarino, Shirley Kuhnen, Rosa Maria Ribeiro-do-Valle, Marcelo Maraschin and Beatriz Veleirinho.


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Nanocarriers in Improving Chemotherapy of Multidrug Resistant Tumors: Key Developments and Perspective


Dimitry A Chistiakov, Veronika A Myasoedova, Alexander N Orekhov and Yuri V Bobryshev.


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Methotrexate in the Treatment of Psoriasis and Rheumatoid Arthritis: Mechanistic Insights, Current Issues and Novel Delivery Approaches


P. Rajitha, Raja Biswas, M. Sabitha and R Jayakumar.


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Scope of Lipid Nanoparticles in Neuroscience: Impact on the Treatment of Neurodegenerative Diseases


Segura-Uribe Julia Jeanette, Ciprés-Flores Fabiola Jimena, Farfán-García Eunice Dalet, Trujillo-Ferrara José Guadalupe and Soriano-Ursúa Marvin Antonio.


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Gelatin as Biomaterial for Tissue Engineering


Mari Carmen Echave, Laura Saenz del Burgo, Jose Luis Pedraz and Gorka Orive.


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New Imaging Frontiers in Cardiology: Fast and Quantitative MAPS from RAW Data


Maria Filomena Santarelli, Nicola Vanello, Michele Scipioni, Giuseppe Valvano and Luigi Landini.


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Myocardial Infarction. Pathological Relevance and Relationship with Coronary Risk Factors


Aurelio Leone.


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Prospect of Combination and Sequential Therapies for Postmenopausal Osteoporosis


Hao Liu and Binbin Li.


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Gender Medicine and Pharmacoeconomics: a Narrative Review of the International Literature of the Last 5 Years. A Revision of Evidences About the Relationship Between Gender and Economic Consumption in Health


Delia Colombo, Lucia Simoni and Emanuela Zagni.


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Curcumin and Lung Cancer: the Role of microRNAs


Diana Lelli, Claudio Pedone, Muhammed Majeed and Amirhosssein Sahebkar.


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Controlled Delivery of Bioactive Molecules for the Treatment of Chronic Wounds


J. Anjana, V. K. Rajan, R. Biswas and R Jayakumar.


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Role of Melatonin in Body Weight: A Systematic Review and Meta-Analysis


Seyed-Ali Mostafavi, Shahin Akhondzadeh, Mohammad Reza Mohammadi, Abbas-Ali Keshtkar, Saeed Hosseini, Mohammad Reza Eshraghian, Fahimeh Ahmadi, Roya Alipour and Seyed Ali Keshavarz.


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3D In Vitro Models of Early Pregnancy: How to Choose the Right Scaffolding Material?


Damián Muzzio, María Lucía Foglia, Martin Federico Desimone and Marek Zygmunt.


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Stress, Neuropeptides and Gastric Mucosa


Klara Gyires and Ágnes Fehér.


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Low Testosterone Levels and Metabolic Syndrome in Aging Male


Rodrigo Blaya, Patrícia Blaya, Luiza Rhoden and Ernani Luis Rhoden.


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Fertility and Sperm Quality in the Aging Male


Susana Almeida, Luís Rato, Mário Sousa, Marco G. Alves and Pedro F Oliveira.


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Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor


Kristian Leisegang, Ralf Henkel and Ashok Agarwal.


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Unravelling the Power of Omics for the Infertile Ageing Male


Paulo Bastos, Maria João Freitas, André Gomes, Rui Vitorino and Margarida Fardilha.


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Multiscale Molecular Simulations Applied to Nucleic Acid- Dendrimer Interactions Studies


Valeria Márquez-Miranda, Ingrid Araya-Durán and Fernando Danilo González-Nilo.


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Xanthine Oxidase and its Role as Target in Cardiovascular Disease: Cardiovascular Protection by Enzyme Inhibition?


Mirjam Schuchardt, Jaqueline Herrmann, Markus Tölle and Markus van der Giet.


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Long-Circulating Liposomal Delivery System Targeting at PDGFR-β Enhances the Therapeutic Effect of IFN-α on Hepatic Fibrosis


Qinghua Li, Qi Yu, Jing Ju, Tiangeng You, Zhiqiang Yan, Xiangli Nan, Jie Zhong and Jing E Zhou.


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Chemical Properties of Caffeic and Ferulic Acids in Biological System: Implications in Cancer Therapy. A Review


Sarah S. Damasceno, Bruna B. Dantas, Jaime Ribeiro-Filho, Demetrius Antônio M. Araújo and José Galberto M da Costa.


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Global Effects Of Early Life Stress On Neurons And Glial Cells


Dueñas Zulma, Caicedo-Mera Juan Carlos and Torner Luz.


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A Comprehensive Review of mTOR-Inhibiting Pharmacotherapy for the Treatment of Non-Infectious Uveitis


Joshua Blair, Robert Barry, David J Moore and Alastair K Denniston.


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Multimeric System of RGD-Grafted PMMA-Nanoparticles as a Targeted Drug- Delivery System for Paclitaxel


Gibbens-Bandala Brenda Vianey, Ocampo-García Blanca Eli, Ferro-Flores Guillermina, Morales-Avila Enrique, Ancira-Cortez Alejandra and Jaimes-Aguirre Laura.


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Targeted Drug Delivery Based on Gold Nanoparticle Derivatives


Mazaher Gholipourmalekabadi, Mohammadmahdi Mobaraki, Maryam Ghaffari, Amir Zarebkohan, Vahid F. Omrani, Aleksandra M. Urbanska and Alexander Seifalian.


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Editorial: Pharmaceutical Applications of Dendrimers


Jose Correa-Basurto.





More than Just Size: Challenges and Opportunities of Hybrid Dendritic Nanocarriers


Guido Noé Rimondino, Gabriela Oksdath-Mansilla, Verónica Brunetti and Miriam Cristina Strumia.


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Recent Advances in Oncological Submissions of Dendrimer


Namrata Soni, Muktika Tekade, Prashant Kesharwani, Pallab Bhattacharya, Rahul Maheshwari, Kamal Dua, Philp M. Hansbro and Rakesh Kumar Tekade.


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Novel Insights into Complex Cardiovascular Pathologies using 4D Flow Analysis by Cardiovascular Magnetic Resonance Imaging


Adam James Lewandowski , Betty Raman , Rajarshi Banerjee and Matteo Milanesi.


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Homocysteine and Non-Cardiac Vascular Disease


Niki Katsiki, Pablo Perez-Martinez and Dimitri P Mikhailidis.


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Advances in Functionalized Mesoporous Silica Nanoparticles for Tumor Targeted Drug Delivery and Theranostics


Wenjia Zhang, Mengrui Liu, Anchang Liu and Guangxi Zhai.


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Markers of Early Vascular Ageing


Vasilios Kotsis, Christina Antza, Ioannis Doundoulakis and Stella Stabouli.


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Environmental Factors and Hypertension


Rosa Maria Bruno , Marina Di Pilla , Carla Ancona , Mette Sørensen , Marco Gesi , Stefano Taddei , Thomas Munzel and Agostino Virdis.


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Circulating Biomarkers of Collagen Metabolism and Prognosis of Heart Failure with Reduced or Mid-Range Ejection Fraction


Joana Moura Ferreira, Sara Moura Ferreira, Maria João Ferreira and Inês Falcão-Pires.


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Efficacy of Ropinirole-Loaded PLGA Microspheres for the Reversion of Rotenone- Induced Parkinsonism


Sofía Negro, Liudmilla Boeva, Karla Slowing, Ana Fernández-Carballido, Luis García-García and Emilia Barcia.


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Calcium Phosphate Nanoparticles Cytocompatibility Versus Cytotoxicity: A Serendipitous Paradox


Milad Pourbaghi Masouleh, Vahid Hosseini, Masoud Pourhaghgouy and Martin K Bakht.


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Gut Microbiota: A New Marker of Cardiovascular Disease


Antonio Garcia-Rios, Jose David Torres-Peña, Francisco Perez-Jimenez and Pablo Perez-Martinez.


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Climate Changes and Human Health: a review of the Effect of Environmental Stressors on Cardiovascular Diseases across Epidemiology and Biological Mechanisms


Paolo Giorgini, Paolo Di Giosia, Marco Petrarca, Francesco Lattanzio, Cosimo Andrea Stamerra and Claudio Ferri.


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BDNF/NF-κB Signaling in the Neurobiology of Depression


Ariel Caviedes, Carlos Lafourcade, Claudio Soto and Ursula Wyneken.


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Recent Advances in Preclinical Studies and Potential Applications of Dendrimers as Drug Carriers in the Central Nervous System


Mariacristina Gagliardi.


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Dendrimers Effects on the Immune System: Insights into Toxicity and Therapeutic Utility


Marina A Dobrovolskaia.


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Surface Engineered Dendrimers in siRNA Delivery and Gene Silencing


Vishakha Tambe, Shreya Thakkar, Nidhi Raval, Dilip Sharma, Kiran Kalia and Rakesh Kumar Tekade.


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Theoretical Studies for Dendrimer-Based Drug Delivery


Martiniano Bello, Jonathan Fragoso-Vázquez and José Correa-Basurto.


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Principal Physicochemical Methods Used to Characterize Dendrimer Molecule Complexes Used as Genetic Therapy Agents, Nanovaccines or Drug Carriers


Rodríguez Fonseca Rolando Alberto, Rodrigues Joao, Muñoz-Fernández María de los Angeles, Martínez Muñoz Alberto, Fragoso Vázquez Manuel Jonathan and Correa Basurto José.


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The Potential Roles of Radionanomedicine and Radioexosomic in Prostate Cancer Research and Treatment


Martin K. Bakht, So Won Oh, Do Won Hwang, Yun-Sang Lee, Hyewon Youn, Lisa A. Porter, Gi Jeong Cheon, Cheol Kwak, Dong Soo Lee and Keon Wook Kang.


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Magnetic Nanoparticles: New Perspectives in Drug Delivery


Joanna Wong, Jeremy Prout and Alexander Seifalian.


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Engineered Muscle Tissues for Disease Modeling and Drug Screening Applications


Mohammad Hossein Mohammadi, Raquel Obregón, Samad Ahadian, Javier Ramón-Azcón and Milica Radisic.


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Angiogenesis and Oxidative Stress in Metastatic Tumor Progression: Pathogenesis and Novel Therapeutic Approach of Colon Cancer


Kathy K. Auyeung and Joshua K Ko.


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Peripheral Corticotropin Releasing Factor Signaling Inhibits Gastric Emptying: Mechanisms of Action and Role in Stress-related Gastric Alterations of Motor Function


József Czimmer and Yvette Taché.


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A Rat Model of Ischemic Enteritis: Pathogenic Importance of Enterobacteria, iNOS/NO, and COX-2/PGE2


Koji Takeuchi, Yoshino Komatsu, Yuka Nakamori and Tohru Kotani.


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Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution?


Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Domagoj Drmic, Mirjana Stupnisek, Antonio Kokot, Marko Sever, Ivan Zoricic, Zoran Zoricic, Lovorka Batelja, Tihomil Ziger, Josipa Vlainic, Zarko Rasic and Martina Lovric Bencic.


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Recent Advances in the Gastric Mucosal Protection Against Stress-induced Gastric Lesions. Importance of Renin-angiotensin Vasoactive Metabolites, Gaseous Mediators and Appetite Peptides


Tomasz Brzozowski, Katarzyna Magierowska, Marcin Magierowski, Agata Ptak-Belowska, Robert Pajdo, Slawomir Kwiecien, Rafal Olszanecki and Ryszard Korbut.


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Gastroprotective Effect of Stress Preconditioning: Involvement of Glucocorticoids


Ludmila Filaretova.


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Stress and Salivary Glands


Beáta Kerémi, Anita Beck, Tibor Károly Fábián, Gábor Fábián, Géza Szabó, Ákos Nagy and Gábor Varga.


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Effective Strategies and Applications of Dendrimers in the Treatment of Ovarian Cancer


Akila Kesavan, Pakala Suresh Babu, Rayala Suresh Kumar and Ganesh Venkatraman.


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GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders


Maja Jazvinšćak Jembrek, Michelangelo Auteri, Rosa Serio and Josipa Vlainić.


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Significance of Cholinergic and Peptidergic Nerves in Stress-Induced Ulcer and MALT Lymphoma Formation


Masahiko Nakamura, Anders Øverby, Akina Uehara, Masaya Oda, Shinichi Takahashi, Somay Y. Murayama and Hidenori Matsui.


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Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress


Akinori Yanaka.


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Natural Approaches in Diabetes Management: A Review of Diet, Exercise, and Natural Products


William M. Schultz, Tina Varghese, Robert E. Hein, Devinder S. Dhindsa, Elliot N. Mahlof, Hannah C. Cai, Geoffrey Southmayd, Pratik B. Sandesaraa, Danny J. Eapen and Laurence S Sperling.


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Editorial: Discovery and Validation of Drug Targets Through Human Genetics and Epigenetics


Karmen Stankov.





2


María José Torres.





Editorial: Towards the Integration of Quantitative and Systems Pharmacology into Drug Discovery: a Systems Level Understanding of Therapeutic and Toxic Effects of Drugs


Violeta I Pérez Nueno.





Editorial: Gut Permeability and the Microbiome: Emerging Roles in CNS Function in Health and Disease


André F. Carvalho, Michael Berk and Michael Maes.





Editorial: Recent Advances in Cancer Research: Targets and New Ligands


Marcela Cristina de Moraes and Fernando de Carvalho da Silva.





Editorial: Mitochondrial and Metabolism: Novel Targets for Heart Failure


Lei Xu and Aijun Sun.





A Case Report of IgG4-related Syndrome and Literature Review


Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo and Antonio Pinto.


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Editorial: Metabolic Disorders, Drug Development, Drug Design and Biomarkers


Gjumrakch Aliev, Ramon Cacabelos and V Prakash Reddy.





Nanotechnology for Drug Delivery: Part III


Jian Zhong.





Editorial: The Pathogenesis of Inflammation and Cancer in the Gastrointestinal Tract: From Basic Science to Translational Medicine


C.H. Cho and HY Wang.





Editorial: Breaking the Skin Barrier: Achievements and the Future


Yasser Shahzad.





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