FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders?

ISSN: 1875-6417 (Online)
ISSN: 1573-3998 (Print)


Volume 13, 6 Issues, 2017


Download PDF Flyer




Current Diabetes Reviews

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Norman E. Cameron
University of Aberdeen
Aberdeen, Scotland
UK


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders?



Current Diabetes Reviews, 12(3): 223-230.

Author(s): Anuradha Pandey, Goru Santosh Kumar, Almesh Kadakol, Vajir Malek and Anil Bhanudas Gaikwad.

Affiliation: Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Pilani 333 031, Rajasthan, India.

Abstract

FoxO1, one of the most widely expressed sub-families of the winged helix forkhead factors, is biologically ‘omni-functional’ owing to its far-flung roles in metabolism, cell cycle, tissue differentiation and development and oxidative stress response. The knowledge of involvement of FoxO1 in metabolic disorders has long been there, but the potential target remained underutilized due to unavailability of specific and potent inhibitors. The review provides an insight into the role of FoxO1 in orchestrating metabolic diseases’ pathogenesis (including diabetes, its secondary complications and obesity) and compiles the literature on FoxO1 inhibitors. The emergence of various natural molecules and synthesized small molecules like AS1842856 as FoxO1 inhibitors urges us to think further and decide the future course of drug development for the management of metabolic disorders.

Keywords:

FoxO1, metabolic disorders, diabetes, diabetic complications, obesity, FoxO1 inhibitors, AS1842856.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 12
Issue Number: 3
First Page: 223
Last Page: 230
Page Count: 8
DOI: 10.2174/1573399811666150804104858
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science