Open Access Articles ::: Current Topics in Medicinal Chemistry

ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)


Volume 17, 32 Issues, 2017


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Current Topics in Medicinal Chemistry

This journal supports open access

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Editor-in-Chief:
Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA


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Open Access Articles

Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena


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InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley


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LncRNA as a Therapeutic Target for Angiogenesis

, 2017; 17(15): 1750 - 1757

Mohan M. Kumar and Ravi Goyal


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Bioinformatics and Drug Discovery

, 2017; 17(15): 1709 - 1726

Xuhua Xia


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A Comprehensive Docking and MM/GBSA Rescoring Study of Ligand Recognition upon Binding Antithrombin

, 2017; 17(14): 1631 - 1639

Xiaohua Zhang, Horacio Perez-Sanchez and Felice C. Lightstone


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Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future

, 2016; 16(29): 3385 - 3403

Peng Li, Gretchen L. Snyder and Kimberly E. Vanover


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Copper Homeostasis for the Developmental Progression of Intraerythrocytic Malarial Parasite

, 2016; 16(27): 3048 - 3057

Hiroko Asahi, Fumie Kobayashi, Shin-Ichi Inoue, Mamoru Niikura, Kenji Yagita and Mohammed Essa Marghany Tolba


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Telomerase as a Cancer Target. Development of New Molecules

, 2016; 16(22): 2432 - 2440

D.L. Mengual Gomez, R.G. Armando, C.S. Cerrudo, P.D. Ghiringhelli and D.E. Gomez


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The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

, 2016; 16(18): 2009 - 2018

Michele Melchionna, Katie E. Styan and Silvia Marchesan


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HCN Channels Modulators: The Need for Selectivity

, 2016; 16(16): 1764 - 1791

Maria Novella Romanelli, Laura Sartiani, Alessio Masi, Guido Mannaioni, Dina Manetti, Alessandro Mugelli and Elisabetta Cerbai


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Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

, 2016; 16(15): 1705 - 1716

Eric P. Trautman and Jason M. Crawford


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Biomarkers in the Management of Difficult Asthma

, 2016; 16(14): 1561 - 1573

Florence Schleich, Sophie Demarche and Renaud Louis


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Cellular Selenoprotein mRNA Tethering via Antisense Interactions with Ebola and HIV-1 mRNAs May Impact Host Selenium Biochemistry

, 2016; 16(13): 1530 - 1535

Ethan Will Taylor, Jan A. Ruzicka, Lakmini Premadasa and Lijun Zhao


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Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies

, 2016; 16(9): 960 - 977

Concepcion Gonzalez-Bello


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αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology

, 2016; 16(3): 314 - 329

Alberto Dal Corso, Luca Pignataro, Laura Belvisi and Cesare Gennari


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Telomere G-Quadruplex as a Potential Target to Accelerate Telomere Shortening by Expanding the Incomplete End-Replication of Telomere DNA

, 2015; 15(19): 1940 - 1946

Zheng Tan, Jun Tang, Zhong-Yuan Kan and Yu-Hua Hao


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Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In V itro

, 2015; 15(18): 1914 - 1929

Angela Ivask, Tiina Titma, Meeri Visnapuu, Heiki Vija, Aleksandr Kakinen, Mariliis Sihtmae, Suman Pokhrel, Lutz Madler, Margit Heinlaan, Vambola Kisand, Ruth Shimmo and Anne Kahru


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Computer-Aided Drug Design of Bioactive Natural Products

, 2015; 15(18): 1780 - 1800

Veda Prachayasittikul, Apilak Worachartcheewan, Watshara Shoombuatong, Napat Songtawee, Saw Simeon, Virapong Prachayasittikul and Chanin Nantasenamat


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Active Targeted Drug Delivery for Microbes Using Nano-Carriers

, 2015; 15(15): 1525 - 1531

Yung-Sheng Lin, Ming-Yuan Lee, Chih-Hui Yang and Keng-Shiang Huang


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Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids

, 2015; 15(15): 1491 - 1500

Chun-Ting Lee, Yen-Wei Huang, Chih-Hui Yang and Keng-Shiang Huang


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Computational Studies of Free Radical-Scavenging Properties of Phenolic Compounds

, 2015; 15(2): 85 - 104

Petko Alov, Ivanka Tsakovska and Ilza Pajeva


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Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

, 2014; 14(22): 2529 - 2541

Rossella Sgarbanti, Donatella Amatore, Ignacio Celestino, Maria Elena Marcocci, Alessandra Fraternale, Maria Rosa Ciriolo, Mauro Magnani, Raffaele Saladino, Enrico Garaci, Anna Teresa Palamara and Lucia Nencioni


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Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

, 2014; 14(16): 1923 - 1938

Evanthia Lionta, George Spyrou, Demetrios K. Vassilatis and Zoe Cournia


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Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

, 2014; 14(3): 340 - 342

David H. Drewry, Timothy M. Willson and William J. Zuercher


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Open Innovation Drug Discovery (OIDD): A Potential Path to Novel Therapeutic Chemical Space

, 2014; 14(3): 294 - 303

Maria Alvim-Gaston, Timothy Grese, Abdelaziz Mahoui, Alan D. Palkowitz, Marta Pineiro-Nunez and Ian Watson


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Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry

, 2014; 14(2): 274 - 289

Sonny Larsson and Nina Ronsted


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A Brief Overview of Antimicrobial Peptides Containing Unnatural Amino Acids and Ligand-Based Approaches for Peptide Ligands

, 2013; 13(24): 3205 - 3224

Jayendra B. Bhonsle, Tiffany Clark, Libero Bartolotti and Rickey P. Hicks


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Native Brazilian Plants Against Nosocomial Infections: A Critical Review on their Potential and the Antimicrobial Methodology

, 2013; 13(24): 3040 - 3078

Paulo Roberto H. Moreno, Fabiana da Costa-Issa, Agnieszka K. Rajca-Ferreira, Marcos A. A. Pereira and Telma M. Kaneko


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From Polypharmacology to Target Specificity: The Case of PARP Inhibitors

, 2013; 13(23): 2939 - 2954

Paride Liscio, Emidio Camaioni, Andrea Carotti, Roberto Pellicciari and Antonio Macchiarulo


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NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects

, 2013; 13(23): 2907 - 2917

Christian Dölle, Renate Hvidsten Skoge, Magali R. VanLinden and Mathias Ziegler


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Recent Advances in the Synthesis of New Antimycobacterial Agents Based on the 1H-1,2,3-Triazoles

, 2013; 13(22): 2850 - 2865

Daniel Tadeu G. Gonzaga, David R. da Rocha, Fernando de C. da Silva and Vitor F. Ferreira


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An Update on the Chemistry and Medicinal Chemistry of Novel Antimycobacterial Compounds

, 2013; 13(22): 2808 - 2849

Frederico Silva Castelo Branco, Angelo C. Pinto and Núbia Boechat


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Synthesis and Biological Evaluation of Potent Antifungal Agents

, 2013; 13(21): 2684 - 2733

Athina Geronikaki, Maria Fesatidou, Victor Kartsev and Fliur Macaev


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A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

, 2013; 13(21): 2648 - 2659

Maria Jose Alves, Isabel C.F.R. Ferreira, Joana Dias, Vania Teixeira, Anabela Martins and Manuela Pintado


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Mucosal Vaccines: Where Do We Stand?

, 2013; 13(20): 2609 - 2628

Jean-Pierre Kraehenbuhl and Marian R. Neutra


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Vaccine Adjuvants: Key Tools for Innovative Vaccine Design

, 2013; 13(20): 2562 - 2580

Peggy Riese, Kai Schulze, Thomas Ebensen, Blair Prochnow and Carlos A. Guzmán


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Challenges and Opportunities for Cancer Vaccines in the Current NSCLC Clinical Scenario

, 2013; 13(20): 2551 - 2561

Pedro C. Rodriguez and Belinda Sanchez


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Therapy in Prion Diseases

, 2013; 13(19): 2465 - 2476

Gianluigi Forloni, Vladimiro Artuso, Ignazio Roiter, Michela Morbin and Fabrizio Tagliavini


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Prion Chemical Biology: On the Road to Therapeutics?

, 2013; 13(19): 2441 - 2464

Beining Chen, Mark Thompson, Jennifer Louth and Kai Guo


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Drug Repurposing: Translational Pharmacology, Chemistry, Computers and the Clinic

, 2013; 13(18): 2328 - 2336

Naiem T. Issa, Stephen W. Byers and Sivanesan Dakshanamurthy


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Overview on Theoretical Studies Discriminating the Two-Oxidant Versus Two-State-Reactivity Models for Substrate Monoxygenation by Cytochrome P450 Enzymes

, 2013; 13(18): 2218 - 2232

Sam P. de Visser, Cristina S. Porro, Matthew G. Quesne, Mala A. Sainna and Andrew W. Munro


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Mitochondria: A Promising Target for Anticancer Alkaloids

, 2013; 13(17): 2171 - 2183

Félix A. Urra, Miguel Cordova-Delgado, Hernan Pessoa-Mahana, Oney Ramírez-Rodríguez, Boris Weiss-Lopez, Jorge Ferreira and Ramiro Araya-Maturana


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Alkaloid-Metal Based Anticancer Agents

, 2013; 13(17): 2104 - 2115

Zhen-Feng Chen, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang


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Retrospection on Polymorphism and Cocrystallization of Anti-Retrovirals

, 2013; 13(16): 1933 - 1962

Renu Chadha, Madhu Bala, Dimpy Rani and Poonam Arora


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Targeting Host Store-Operated Ca2+ Release to Attenuate Viral Infections

, 2013; 13(16): 1916 - 1932

Kevin B. Clark and E. M. Eisenstein


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Emerging Targets in Neurodegeneration: New Opportunities for Alzheimer's Disease Treatment?

, 2013; 13(15): 1879 - 1904

Angela Rampa, Silvia Gobbi, Federica Belluti and Alessandra Bisi


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The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics

, 2013; 13(15): 1745 - 1770

M. Carmo Carreiras, Eduarda Mendes, M. Jesus Perry, Ana Paula Francisco and J. Marco-Contelles


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Simultaneous Modeling of Antimycobacterial Activities and ADMET Profiles: A Chemoinformatic Approach to Medicinal Chemistry

, 2013; 13(14): 1656 - 1665

Alejandro Speck-Planche and M. N.D.S. Cordeiro


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Recent Advances in Predicting Protein Classification and Their Applications to Drug Development

, 2013; 13(14): 1622 - 1635

Xuan Xiao, Wei-Zhong Lin and Kuo-Chen Chou


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The Emerging Role of microRNA in Stroke

, 2013; 13(13): 1573 - 1588

Georgios Koutsis, Gerasimos Siasos and Konstantinos Spengos


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Insights in microRNAs Biology

, 2013; 13(13): 1493 - 1502

Antonios N. Gargalionis and Efthimia K. Basdra


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Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets

, 2013; 13(12): 1441 - 1453

Brianne S. Raccor and Rudiger Kaspera


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CYP17A1: A Biochemistry, Chemistry, and Clinical Review

, 2013; 13(12): 1364 - 1384

David Porubek


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Pharmacophore Modeling for ADME

, 2013; 13(11): 1327 - 1342

Osman F. Guner and J. Phillip Bowen


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Permeability Diagnosis Model in Drug Discovery: A Diagnostic Tool to Identify the Most Influencing Properties for Gastrointestinal Permeability

, 2013; 13(11): 1308 - 1316

Jianling Wang and Suzanne Skolnik


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Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design

, 2013; 13(10): 1242 - 1253

Jing-Fang Wang and Kuo-Chen Chou


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Open Source Software and Web Services for Designing Therapeutic Molecules

, 2013; 13(10): 1172 - 1191

Deepak Singla, Sandeep Kumar Dhanda, Jagat Singh Chauhan, Anshu Bhardwaj, Samir K. Brahmachari, Open Source Drug Discovery Consortium and Gajendra P.S. Raghava


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Protein Interface Pharmacophore Mapping Tools for Small Molecule Protein: Protein Interaction Inhibitor Discovery

, 2013; 13(9): 989 - 1001

Arnout Voet, Eleanor F. Banwell, Kamlesh K. Sahu, Jonathan G. Heddle and Kam Y. J. Zhang


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A Novel Integrated Framework and Improved Methodology of Computer-Aided Drug Design

, 2013; 13(9): 965 - 988

Calvin Yu-Chian Chen


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Fluorine-18 Radiolabeled Heterocycles as PET Tracers for Imaging β - Amyloid Plaques in Alzheimer’s Disease

, 2013; 13(8): 909 - 919

Fanxing Zeng and Mark M. Goodman


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Fluorine-18 Labeled Amino Acids for Oncologic Imaging with Positron Emission Tomography

, 2013; 13(8): 871 - 891

Chaofeng Huang and Jonathan McConathy


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Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters

, 2013; 13(7): 857 - 866

Meihua Tu, Alan M. Mathiowetz, Jeffrey A. Pfefferkorn, Kimberly O. Cameron, Robert L. Dow, John Litchfield, Li Di, Bo Feng and Spiros Liras


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Intestinal Targeting of Drugs: Rational Design Approaches and Challenges

, 2013; 13(7): 776 - 802

Kevin J. Filipski, Manthena V. Varma, Ayman F. El-Kattan, Catherine M. Ambler, Roger B. Ruggeri, Theunis C. Goosen and Kimberly O. Cameron


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Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis

, 2013; 13(6): 760 - 773

Jose A. Gomez-Puerta and Attila Mocsai


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The Genetic Architecture of Rheumatoid Arthritis: From Susceptibility to Clinical Subphenotype Associations

, 2013; 13(6): 720 - 731

Antonio Julia and Sara Marsal


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Rheumatoid Arthritis: A Clinical Overview of New Diagnostic and Treatment Approaches

, 2013; 13(6): 698 - 704

Raimon Sanmarti, Virginia Ruiz-Esquide and Maria Victoria Hernandez


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From Protein-Protein Interactions to Rational Drug Design: Are Computational Methods Up to the Challenge?

, 2013; 13(5): 602 - 618

Edgar D. Coelho, Joel P. Arrais and Jose Luis Oliveira


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The Impact of Computer Science in Molecular Medicine: Enabling High- Throughput Research

, 2013; 13(5): 526 - 575

Diana de la Iglesia, Miguel Garcia-Remesal, Guillermo de la Calle, Casimir Kulikowski, Ferran Sanz and Victor Maojo


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Chemistry and Theranostic Applications of Radiolabeled Nanoparticles for Cardiovascular, Oncological, and Pulmonary Research

, 2013; 13(4): 470 - 478

Yunjun Guo, Tolulope Aweda, Kvar C.L. Black and Yongjian Liu


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Gd-based Macromolecules and Nanoparticles as Magnetic Resonance Contrast Agents for Molecular Imaging

, 2013; 13(4): 411 - 421

Ching-Hui Huang and Andrew Tsourkas


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Endogenous Modulators of TRP Channels

, 2013; 13(3): 398 - 407

Enza Palazzo, Francesco Rossi, Vito de Novellis and Sabatino Maione


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Oncogenic and Anti-Oncogenic Effects of Transient Receptor Potential Channels

, 2013; 13(3): 344 - 366

Sonia Liberati, Maria Beatrice Morelli, Massimo Nabissi, Matteo Santoni and Giorgio Santoni


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MicroRNAs and the Heart: Small Things Do Matter

, 2013; 13(2): 216 - 230

Nikolaos Papoutsidakis, Spyridon Deftereos, Andreas Kaoukis, Georgios Bouras, Georgios Giannopoulos, Andreas Theodorakis, Christos Angelidis, Georgios Hatzis and Christodoulos Stefanadis


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Myeloperoxidase: Expressing Inflammation and Oxidative Stress in Cardiovascular Disease

, 2013; 13(2): 115 - 138

Nikolaos Anatoliotakis, Spyridon Deftereos, Georgios Bouras, Georgios Giannopoulos, Dimitrios Tsounis, Christos Angelidis, Andreas Kaoukis and Christodoulos Stefanadis


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Computational Tools in the Discovery of New G-Quadruplex Ligands with Potential Anticancer Activity

, 2012; 12(24): 2843 - 2856

Daimel Castillo-Gonzalez, Gisselle Perez-Machado, Federico Pallardo, Teresa-Maria Garrigues-Pelufo and Miguel-Angel Cabrera-Perez


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Classification Models for Anticancer Activity

, 2012; 12(24): 2705 - 2726

R. Dutt and A.K. Madan


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Tetraamine-Coupled Peptides and Resulting 99mTc-Radioligands: An Effective Route for Receptor-Targeted Diagnostic Imaging of Human Tumors

, 2012; 12(23): 2655 - 2667

Berthold A. Nock and Theodosia Maina


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Alpha-Emitters for Immuno-Therapy: A Review of Recent Developments from Chemistry to Clinics

, 2012; 12(23): 2642 - 2654

Sandrine Huclier-Markai, Cyrille Alliot, Nicolas Varmenot, Cathy S. Cutler and Jacques Barbet


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SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status

, 2012; 12(22): 2560 - 2572

Yuewei Sheng, Madhuri Chattopadhyay, Julian Whitelegge and Joan Selverstone Valentine


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Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones

, 2012; 12(22): 2534 - 2545

Jarl Underhaug, Oscar Aubi and Aurora Martinez


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Protein Misfolding in Disease and Small Molecule Therapies

, 2012; 12(22): 2460 - 2469

Claudio M. Gomes


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Conceptual Issues in Psychiatric Neuroimaging: An Update

, 2012; 12(21): 2348 - 2356

D. Stoyanov, G. Stanghellini and M. Broome


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Neurofunctional Correlates of Theory of Mind Deficits in Schizophrenia

, 2012; 12(21): 2284 - 2302

M. Bosia, R. Riccaboni and S. Poletti


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History and Therapeutic Use of MAO-A Inhibitors: A Historical Perspective of MAO-A Inhibitors As Antidepressant Drug

, 2012; 12(20): 2275 - 2282

Matilde Yanez, Juan Fernando Padin, Juan Alberto Arranz-Tagarro, Mercedes Camina and Reyes Laguna


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Monoamine Oxidase Inhibitors: Ten Years of Docking Studies

, 2012; 12(20): 2145 - 2162

Giulio Ferino, Santiago Vilar, Maria J. Matos, Eugenio Uriarte and Enzo Cadoni


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Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling

, 2012; 12(19): 2103 - 2113

Nathalia G. Amado, Barbara F. Fonseca, Debora Malta Cerqueira, Alice H. Reis, Alessandro Bolis Costa Simas, Ricardo Machado Kuster, Fabio A. Mendes and Jose G. Abreu


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The Central Nervous System as a Promising Target to Treat Diabetes Mellitus

, 2012; 12(19): 2070 - 2081

Jose Donato Jr.


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Rational Prediction with Molecular Dynamics for Hit Identification

, 2012; 12(18): 2002 - 2012

Sara E. Nichols, Robert V. Swift and Rommie E. Amaro


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A Survey of Quantitative Descriptions of Molecular Structure

, 2012; 12(18): 1946 - 1956

Rajarshi Guha and Egon Willighagen


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Enzyme Informatics

, 2012; 12(17): 1911 - 1923

Rosanna G. Alderson, Luna De Ferrari, Lazaros Mavridis, James L. McDonagh, John B.O. Mitchell and Neetika Nath


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Compound Activity Prediction Using Models of Binding Pockets or Ligand Properties in 3D

, 2012; 12(17): 1869 - 1882

Irina Kufareva, Yu-Chen Chen, Andrey V. Ilatovskiy and Ruben Abagyan


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A Parallel Systematic-Monte Carlo Algorithm for Exploring Conformational Space

, 2012; 12(16): 1790 - 1796

Yasset Perez-Riverol, Roberto Vera, Yuliet Mazola and Alexis Musacchio


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QSAR and Molecular Docking Techniques for the Discovery of Potent Monoamine Oxidase B Inhibitors: Computer-Aided Generation of New Rasagiline Bioisosteres

, 2012; 12(16): 1734 - 1747

Alejandro Speck-Planche and Valeria V. Kleandrova


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Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy

, 2012; 12(15): 1693 - 1712

Giorgia Urbinati, Veronique Marsaud and Jack-Michel Renoir


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Novel Gene Transfer Systems: Intelligent Gene Transfer Vectors for Gene Medicines

, 2012; 12(15): 1594 - 1602

Toshihiro Nakajima


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Cysteine-Rich Mini-Proteins in Human Biology

, 2012; 12(14): 1514 - 1533

Vincent Lavergne, Ryan J. Taft and Paul F. Alewood


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Towards Isozyme-Selective HDAC Inhibitors For Interrogating Disease

, 2012; 12(14): 1479 - 1499

Praveer Gupta, Robert C. Reid, Abishek Iyer, Matthew J. Sweet and David P. Fairlie


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Thalidomide: Chemistry, Therapeutic Potential and Oxidative Stress Induced Teratogenicity

, 2012; 12(13): 1436 - 1455

Neeraj Kumar, Upendra Sharma, Chitra Singh and Bikram Singh


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From the Deepest Sea Shelf to the Uppermost Kitchen Cabinet Shelf: The Quest for Novel TNF-α Inhibitors

, 2012; 12(13): 1392 - 1407

F. Folmer, M. Dicato and M. Diederich


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Identifying Multiple-target Ligands via Computational Chemogenomics Approaches

, 2012; 12(12): 1363 - 1375

Shiming Peng, Xingyu Lin, Zongru Guo and Niu Huang


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Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets

, 2012; 12(12): 1331 - 1345

Louise Cathrine Braun Olsen and Nils Joakim Faergeman


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The IC50 Concept Revisited

, 2012; 12(11): 1282 - 1290

Gary W. Caldwell, Zhengyin Yan, Wensheng Lang and John A. Masucci


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An Integrated Data Management Framework for Drug Discovery – From Data Capturing to Decision Support

, 2012; 12(11): 1237 - 1242

Walter Cedeno, Simson Alex, Edward P. Jaeger, Dimitris K. Agrafiotis and Victor S. Lobanov


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Novel Therapeutic Approaches Targeting Matrix Metalloproteinases in Cardiovascular Disease

, 2012; 12(10): 1214 - 1221

Alexandros Briasoulis, Dimitris Tousoulis, Nikolaos Papageorgiou, Anna-Maria Kampoli, Emmanuel Androulakis, Charalambos Antoniades, Eleftherios Tsiamis, George Latsios and Christodoulos Stefanadis


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Myocardial Structure and Matrix Metalloproteinases

, 2012; 12(10): 1113 - 1131

C. Aggeli, P. Pietri, I. Felekos, L. Rautopoulos, K. Toutouzas, E. Tsiamis and C. Stefanadis


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Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants

, 2012; 12(9): 971 - 993

Rosaria Gitto, Laura De Luca, Sara De Grazia and Alba Chimirri


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Recent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disorders

, 2012; 12(9): 1033 - 1071

Sevim Dalkara and Arzu Karakurt


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Freely Accessible Databases of Commercial Compounds For High- Throughput Virtual Screenings

, 2012; 12(8): 866 - 877

Armenio Jorge Moura Barbosa and Alberto Del Rio


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Computer-Aided Drug Design Methodologies Toward the Design of Anti-Hepatitis C Agents

, 2012; 12(8): 802 - 813

Alejandro Speck-Planche and M. Natalia D. S. Cordeiro


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Natural Products as Leads for Tuberculosis Drug Development

, 2012; 12(7): 735 - 765

Christine E. Salomon and Lori E. Schmidt


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Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds

, 2012; 12(7): 672 - 693

Pan Pan and Peter J. Tonge


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Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors

, 2012; 12(6): 548 - 584

Maria P. Menendez-Gutierrez, Tamas Roszer and Mercedes Ricote


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General Molecular Biology and Architecture of Nuclear Receptors

, 2012; 12(6): 486 - 504

Michal Pawlak, Philippe Lefebvre and Bart Staels


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Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

, 2012; 12(5): 473 - 483

Arnab K. Chatterjee and Bryan K.S. Yeung


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Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target

, 2012; 12(5): 456 - 472

Veronica M. Zhang, Marina Chavchich and Norman C. Waters


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Reversed Chloroquine Molecules as a Strategy to Overcome Resistance in Malaria

, 2012; 12(5): 400 - 407

David H. Peyton


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Synthetic Peroxides as Potent Antimalarials. News and Views

, 2012; 12(5): 373 - 399

Charles W. Jefford


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Translocator Protein as a Promising Target for Novel Anxiolytics

, 2012; 12(4): 270 - 285

Barbara Costa, Eleonora Da Pozzo and Claudia Martini


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Treatment Strategies of Obsessive-Compulsive Disorder and Panic Disorder/Agoraphobia

, 2012; 12(4): 238 - 253

Donatella Marazziti, Marina Carlini and Liliana Dell'Osso


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Terpyridines and their Complexes with First Row Transition Metal Ions:Cytotoxicity, Nuclease Activity and Self-Assembly of Biomacromolecules

, 2012; 12(3): 158 - 175

Andreas Winter, Michael Gottschaldt, George R. Newkome and Ulrich S. Schubert


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Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions

, 2012; 12(3): 122 - 144

Linus Chiang, Michael R. Jones, Cara L. Ferreira and Tim Storr


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RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy

, 2012; 12(2): 69 - 78

Marzia Pennati, Enrico Millo, Paolo Gandellini, Marco Folini and Nadia Zaffaroni


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Polymeric Carrier Systems for siRNA Delivery

, 2012; 12(2): 108 - 119

P. Vader, L. J. van der Aa, G. Storm, R. M. Schiffelers and J. F.J. Engbersen


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Thalamocortical Oscillations: Local Control of EEG Slow Waves

, 2011; 11(19): 2457 - 2471

Igor Timofeev and Sylvain Chauvette


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Rapid Analysis of Pharmacology for Infectious Diseases

, 2011; 11(10): 1292 - 1300

Andrew L. Hopkins, G. Richard Bickerton, Ian M. Carruthers, Stephen K. Boyer, Harvey Rubin and John P. Overington


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Target Validation: Linking Target and Chemical Properties to Desired Product Profile

, 2011; 11(10): 1275 - 1283

Paul G. Wyatt, Ian H. Gilbert, Kevin D. Read and Alan H. Fairlamb


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Transcriptional Regulation by Promoter Targeted RNAs

, 2009; 9(12): 1079 - 1087

Kazuo Suzuki and Anthony D. Kelleher


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IRAK-4 Inhibitors for Inflammation

, 2009; 9(8): 724 - 737

Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh


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Melanocortins in the Treatment of Male and Female Sexual Dysfunction

, 2007; 7(11): 1137 - 1144

Trevor J. Hallam, Carl Spana, Dennis C. Earle, Annette M. Shadiack and Shubh D. Sharma


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Morpholino, siRNA, and S-DNA Compared: Impact of Structure and Mechanism of Action on Off-Target Effects and Sequence Specificity

, 2007; 7(7): 651 - 660

James E. Summerton


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